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The map label for this gene is pyrH

Identifier: 15921566

GI number: 15921566

Start: 1300401

End: 1301081

Strand: Direct

Name: pyrH

Synonym: ST1300

Alternate gene names: 15921566

Gene position: 1300401-1301081 (Clockwise)

Preceding gene: 15921565

Following gene: 15921567

Centisome position: 48.26

GC content: 30.1

Gene sequence:

>681_bases
ATGAAGTTAGTTCTTAAGATAAGTGGTAAATTTTTTGATGAGGAGAATATTGAAAATTTTATTTCATTAAGAAATACTAT
AAAAAATATTGTTAATGAGGGTCATAGACTAGCAATAGTAAGTGGTGGAGGTTCTACAGCTAGAAAATATATCAAAATAG
GAAGAGAGTTAGGGGTAAATGAAGCCCACTTAGACTTATTAGGAATATGGGCCTCAAGGTTAAATGCTTATTTGCTAACC
TTTATACTCTCTGATTTAAGTTACATGAAAGTACCAGAAAATTTAGAGGAATTTATTGAAAAATGGGAAAGTGAGAAAGT
AGTTATTACAGGTGGTTTTCAACCTGGGCAATCCACAGCTACAGTAGCTGCTCTAGTTAGTGAAGCCATAGCAGCTGATT
ATCTTATCTTAGCTACAAACGTAGATGGTGTATACGATAAAGATCCTAGGTATAATAAAGATGCAAAATTACTTTCTAAA
TTAAATACAGAAACATTAAAGAAAATTTTAGAAACATCACAATCAGTCAAAGCAGGAACTTACGAGTTGCTTGATCCATT
AGCAATAAAAATTATAGAAAGATCAAAAATAAAAGTAATTGTGATGAATTATAAAAGGCTTAATAAAATTTTAGATATTA
TTCATGGTAAAGATATTGGTAGTATAATTGAACCGATGTGA

Upstream 100 bases:

>100_bases
GATTATTCAAAGACCCAGAAACTGGGAAATATTTTAGGCATAAATTGCCAGATGATTATCCAGTCTAAACTTTTTAATAA
AGTCATAATATTTTTCAAAG

Downstream 100 bases:

>100_bases
TAAAAATGTCTATATTAAATGAAGAGGAATTTAGGCTATTAAGAGAGCATAGAGGTAAAGTAAATATAAATATAGTAGAA
AAGATATTAACCGAGATAGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKLVLKISGKFFDEENIENFISLRNTIKNIVNEGHRLAIVSGGGSTARKYIKIGRELGVNEAHLDLLGIWASRLNAYLLT
FILSDLSYMKVPENLEEFIEKWESEKVVITGGFQPGQSTATVAALVSEAIAADYLILATNVDGVYDKDPRYNKDAKLLSK
LNTETLKKILETSQSVKAGTYELLDPLAIKIIERSKIKVIVMNYKRLNKILDIIHGKDIGSIIEPM

Sequences:

>Translated_226_residues
MKLVLKISGKFFDEENIENFISLRNTIKNIVNEGHRLAIVSGGGSTARKYIKIGRELGVNEAHLDLLGIWASRLNAYLLT
FILSDLSYMKVPENLEEFIEKWESEKVVITGGFQPGQSTATVAALVSEAIAADYLILATNVDGVYDKDPRYNKDAKLLSK
LNTETLKKILETSQSVKAGTYELLDPLAIKIIERSKIKVIVMNYKRLNKILDIIHGKDIGSIIEPM
>Mature_226_residues
MKLVLKISGKFFDEENIENFISLRNTIKNIVNEGHRLAIVSGGGSTARKYIKIGRELGVNEAHLDLLGIWASRLNAYLLT
FILSDLSYMKVPENLEEFIEKWESEKVVITGGFQPGQSTATVAALVSEAIAADYLILATNVDGVYDKDPRYNKDAKLLSK
LNTETLKKILETSQSVKAGTYELLDPLAIKIIERSKIKVIVMNYKRLNKILDIIHGKDIGSIIEPM

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_SULTO (Q971S6)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377235.1
- ProteinModelPortal:   Q971S6
- SMR:   Q971S6
- GeneID:   1459302
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1300
- NMPDR:   fig|273063.1.peg.1403
- HOGENOM:   HBG497552
- OMA:   TRANAML
- ProtClustDB:   PRK00358
- BioCyc:   STOK273063:ST1300-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25254; Mature: 25254

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: BINDING 43-43 BINDING 44-44 BINDING 48-48 BINDING 65-65 BINDING 139-139 BINDING 140-140 BINDING 145-145 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLKISGKFFDEENIENFISLRNTIKNIVNEGHRLAIVSGGGSTARKYIKIGRELGVN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCC
EAHLDLLGIWASRLNAYLLTFILSDLSYMKVPENLEEFIEKWESEKVVITGGFQPGQSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCHHH
TVAALVSEAIAADYLILATNVDGVYDKDPRYNKDAKLLSKLNTETLKKILETSQSVKAGT
HHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCH
YELLDPLAIKIIERSKIKVIVMNYKRLNKILDIIHGKDIGSIIEPM
HHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MKLVLKISGKFFDEENIENFISLRNTIKNIVNEGHRLAIVSGGGSTARKYIKIGRELGVN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCC
EAHLDLLGIWASRLNAYLLTFILSDLSYMKVPENLEEFIEKWESEKVVITGGFQPGQSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCHHH
TVAALVSEAIAADYLILATNVDGVYDKDPRYNKDAKLLSKLNTETLKKILETSQSVKAGT
HHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCH
YELLDPLAIKIIERSKIKVIVMNYKRLNKILDIIHGKDIGSIIEPM
HHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479