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The map label for this gene is thrC [H]

Identifier: 15921503

GI number: 15921503

Start: 1241780

End: 1242967

Strand: Direct

Name: thrC [H]

Synonym: ST1240

Alternate gene names: 15921503

Gene position: 1241780-1242967 (Clockwise)

Preceding gene: 15921501

Following gene: 15921504

Centisome position: 46.08

GC content: 34.76

Gene sequence:

>1188_bases
ATGCAAGGCTATCTAAAATGCTTAGACTGTGGATCAGAATATCCTATCCAACAAGATATTATAACTTGTCCTAAATGTGG
AGGATTATTAGAGATAATTGTTGAACCTAAGAAAGACTTCTCATTCAGTAAACTAAAAGGGAAAGGAGTTTGGAGATATA
GAGAATTAATAGCTGGAGAATACAAACATATAGTTAGTTTAAATGAAGGAAATACCCCACTAATTGCTTCTTCTACTAAT
AAAAATCTATATTTTAAGTTTGAAGGAGCCAACCCTACTGGAAGTTTTAAAGATAGAGGAATGACAGTAGCTATAAGTTC
CGCTAAATCATTAAACTATAAAGTTGTAGTAGCTGCATCTACTGGAAATACTGCAGCTTCAGCCGCTGCATATGCAAGTA
GAGCTGGTTTAAGAAGTTACATTGTATTACCTAAAGGAAAAGTTGCTTTAGGAAAATTGGCTCAATCTATACTTTATGGG
ACTACTATACTTGAAGTTGATGGCAGTTTTGATGTTGCTATGAATAGTGTAATGAAATTATATAGAGAACTAAAAATAGT
TTATCCGCTTAACTCTTTTAATCCATGGAGACTTGAAGGACAAAAAACTATTGCTTTTGAAATAGTTGAGGATATTGGAG
TACCTGATAATGTGATAGTACCCGTAGGTAATGCCGGAAACATTTATGCTATATGGAAGGGATTTGTAGAGTTAATGAAT
ATTGGGGTTACCGATAAAGTACCTAGAATGATTGGGATACAAGCTGAAGGAGCAGCGCCAATAGCTAAGGCTCTAGAAAA
AGGATTAGATAAACCGGAATTTATAGATTCACCTGAAACTGTAGCCTCTGCTATAAGAATAGGTAAACCAGTGAACTGGA
AAAAAGCAATTAAGGCTATAAAATCATCTAATGGATTTGCAACTTATGTTTCTGACTCTGAGATCTTAGAGGCGCAAAAA
GAATTAGCTAGGAGAGAGGGAATAGGTGCAGAACCTGCATCAGCTGCTTCCTATGCTGGTTATTTAAAGCTTGTAAATTC
TGGCAAAATTGATAAAAGCGAAAAAACTGTTTTAATTTTAACTGGGCATGCGCTAAAGGACCCAGATGCGATGATAAAAG
CTGAATCACGAAGAATTTTAGTTAACCCAGAACATATAAATGAAATAATCTTGAGTGATCTAAAATGA

Upstream 100 bases:

>100_bases
GAGAATGCCAAATTAATCACTAGATTAGTATTCATAAGATAAAGCTTATAATTTAGTATACAAAAGAGCTTTACGTTAGT
GGTGAGCTATAGTTGGAAAC

Downstream 100 bases:

>100_bases
AAGTAATTAAAATAGGTGGATCTATTCAAAAAGATGAAAAAGACTATGAATTAATATTAGATAAATTAAAGAAAGAAATT
GATTATAATGATAAAAACAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MQGYLKCLDCGSEYPIQQDIITCPKCGGLLEIIVEPKKDFSFSKLKGKGVWRYRELIAGEYKHIVSLNEGNTPLIASSTN
KNLYFKFEGANPTGSFKDRGMTVAISSAKSLNYKVVVAASTGNTAASAAAYASRAGLRSYIVLPKGKVALGKLAQSILYG
TTILEVDGSFDVAMNSVMKLYRELKIVYPLNSFNPWRLEGQKTIAFEIVEDIGVPDNVIVPVGNAGNIYAIWKGFVELMN
IGVTDKVPRMIGIQAEGAAPIAKALEKGLDKPEFIDSPETVASAIRIGKPVNWKKAIKAIKSSNGFATYVSDSEILEAQK
ELARREGIGAEPASAASYAGYLKLVNSGKIDKSEKTVLILTGHALKDPDAMIKAESRRILVNPEHINEIILSDLK

Sequences:

>Translated_395_residues
MQGYLKCLDCGSEYPIQQDIITCPKCGGLLEIIVEPKKDFSFSKLKGKGVWRYRELIAGEYKHIVSLNEGNTPLIASSTN
KNLYFKFEGANPTGSFKDRGMTVAISSAKSLNYKVVVAASTGNTAASAAAYASRAGLRSYIVLPKGKVALGKLAQSILYG
TTILEVDGSFDVAMNSVMKLYRELKIVYPLNSFNPWRLEGQKTIAFEIVEDIGVPDNVIVPVGNAGNIYAIWKGFVELMN
IGVTDKVPRMIGIQAEGAAPIAKALEKGLDKPEFIDSPETVASAIRIGKPVNWKKAIKAIKSSNGFATYVSDSEILEAQK
ELARREGIGAEPASAASYAGYLKLVNSGKIDKSEKTVLILTGHALKDPDAMIKAESRRILVNPEHINEIILSDLK
>Mature_395_residues
MQGYLKCLDCGSEYPIQQDIITCPKCGGLLEIIVEPKKDFSFSKLKGKGVWRYRELIAGEYKHIVSLNEGNTPLIASSTN
KNLYFKFEGANPTGSFKDRGMTVAISSAKSLNYKVVVAASTGNTAASAAAYASRAGLRSYIVLPKGKVALGKLAQSILYG
TTILEVDGSFDVAMNSVMKLYRELKIVYPLNSFNPWRLEGQKTIAFEIVEDIGVPDNVIVPVGNAGNIYAIWKGFVELMN
IGVTDKVPRMIGIQAEGAAPIAKALEKGLDKPEFIDSPETVASAIRIGKPVNWKKAIKAIKSSNGFATYVSDSEILEAQK
ELARREGIGAEPASAASYAGYLKLVNSGKIDKSEKTVLILTGHALKDPDAMIKAESRRILVNPEHINEIILSDLK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=169, Percent_Identity=32.5443786982249, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789505, Length=251, Percent_Identity=28.6852589641434, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 42809; Mature: 42809

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGYLKCLDCGSEYPIQQDIITCPKCGGLLEIIVEPKKDFSFSKLKGKGVWRYRELIAGE
CCCCEEEECCCCCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHCC
YKHIVSLNEGNTPLIASSTNKNLYFKFEGANPTGSFKDRGMTVAISSAKSLNYKVVVAAS
CEEEEEECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEEEC
TGNTAASAAAYASRAGLRSYIVLPKGKVALGKLAQSILYGTTILEVDGSFDVAMNSVMKL
CCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
YRELKIVYPLNSFNPWRLEGQKTIAFEIVEDIGVPDNVIVPVGNAGNIYAIWKGFVELMN
HHHEEEEEECCCCCCEEECCCEEEEEEEHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHH
IGVTDKVPRMIGIQAEGAAPIAKALEKGLDKPEFIDSPETVASAIRIGKPVNWKKAIKAI
CCCCCCCCHHEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
KSSNGFATYVSDSEILEAQKELARREGIGAEPASAASYAGYLKLVNSGKIDKSEKTVLIL
HCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEECCCCCCCCCCEEEEE
TGHALKDPDAMIKAESRRILVNPEHINEIILSDLK
ECCCCCCCHHHEEECCCEEEECHHHHHHHHHHCCC
>Mature Secondary Structure
MQGYLKCLDCGSEYPIQQDIITCPKCGGLLEIIVEPKKDFSFSKLKGKGVWRYRELIAGE
CCCCEEEECCCCCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHCC
YKHIVSLNEGNTPLIASSTNKNLYFKFEGANPTGSFKDRGMTVAISSAKSLNYKVVVAAS
CEEEEEECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEEEC
TGNTAASAAAYASRAGLRSYIVLPKGKVALGKLAQSILYGTTILEVDGSFDVAMNSVMKL
CCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
YRELKIVYPLNSFNPWRLEGQKTIAFEIVEDIGVPDNVIVPVGNAGNIYAIWKGFVELMN
HHHEEEEEECCCCCCEEECCCEEEEEEEHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHH
IGVTDKVPRMIGIQAEGAAPIAKALEKGLDKPEFIDSPETVASAIRIGKPVNWKKAIKAI
CCCCCCCCHHEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
KSSNGFATYVSDSEILEAQKELARREGIGAEPASAASYAGYLKLVNSGKIDKSEKTVLIL
HCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEECCCCCCCCCCEEEEE
TGHALKDPDAMIKAESRRILVNPEHINEIILSDLK
ECCCCCCCHHHEEECCCEEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]