The gene/protein map for NC_003106 is currently unavailable.
Definition Sulfolobus tokodaii str. 7 chromosome, complete genome.
Accession NC_003106
Length 2,694,756

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The map label for this gene is lig

Identifier: 15920405

GI number: 15920405

Start: 245891

End: 247693

Strand: Reverse

Name: lig

Synonym: ST0223

Alternate gene names: 15920405

Gene position: 247693-245891 (Counterclockwise)

Preceding gene: 15920407

Following gene: 15920404

Centisome position: 9.19

GC content: 34.22

Gene sequence:

>1803_bases
ATGGAGTTTAAACTCATAGCTGAATACTTTGATAAACTTGAGAAGATATCTTCAAGGCTTCAACTTACCGCATTACTAAC
TGATCTGTTTAAAAAGGCTGATAAAAATGTCATTGATAAGGTAGTTTATTTAATTCAGGGTAAATTGTGGCCAGACTTTT
TAGGCTATCCAGAGTTAGGAGTTGGTGAAAAATTACTTATTAAAGCAATTTCGATTGCTGTGAATGTCAAAGAGGAAGTA
GTAGAAGAGCAATTGAAAGTTGTTGGTGACTTAGGAGAAGTTGCGATGAGACTTAAGAAAACTCCTCAGTCTGCCTCAAT
TTTAAGCTTCTTAGGTGCTCAATCAAATGAAGGTTTAACCGTTGAAGAAACTTATGAATCTTTGACTAAAATAGCGTTGG
CTTCAGGTGAGGGTAGTAGAGATATTAAAATTAGATCTTTAGCTGGGTTACTAAAGAAGGCTTCTCCTTTAGAAGCAAAA
TACATAGTTAGGTTCGTAGATGGAAGATTAAGAGTTGGAATCGGTGATGCCACAATAATGGATGCACTATCAACAGCATT
TACCGGGAGTACTTCATTTAGACCATTAATAGAAAGAGCATATAATTTAAGAGCGGATCTAGGTAATATTGCAAAAATTA
TTGCGCAACAAGGCGTAGAAGCTTTAAAGGACATTAAACCTCAAGTAGGAATTCCTATAAGGCCGATGTTAGCAGAAAGA
ATGAGTGATCCTGCAGAGATTTTAGCTAAAGTAGGCGGTGAAGCTTTAGTAGATTACAAATATGATGGGGAACGTGCACA
AATACATAAAAAGGATAAAGAAGTATATATATTCTCTAGAAGATTGGAGAATATTACTAGAATGTATCCTGATGTTGTGG
AATATGTAAGAGAATACATAAACGCTAATGAAGTTATAATTGAAGGAGAGATAGTAGCTGTAGACCCAGAAAGTAATGAG
ATTAGACCATTTCAAGAGTTAATGCATAGGAAAAGAAAGAATGATATAAATGAAGCTATAAAGGAATATCCAGTAAACGT
TTATCTTTTTGATTTAATGCTTTATGAAGATGCAGATTATACCATGAAGCCTTTGCCAGAAAGAAGAAAGAAACTAGAAG
AAGTTATTAAACCAAATGATAAATTACATATAGCTCATCATATTTATACAAATAATGTAGATAAACTGATGGAATTCTTT
TATGATGCTATAAGCAATGGAGCAGAAGGTGTAATGGTGAAATCGGTTGCTAAAGATTCTATATATCAGGCAGGTTCTAG
AGGTTTCTTATGGATTAAACTGAAGAGAGATTATCAAAGCGAGATGGCTGACAGCGTTGATCTAGTAGTAGTAGGAGCAT
TTTATGGAAGAGGAAAAAGAGGAGGTAAATTGAGTTCATTATTAATGGCTGCATATGACCCAGAGACAGATACATTTAAA
ACCGTATGTAAAGTAGCATCCGGCTTTAGTGATGCCGAATTAGATGAATTGCAAAAGAAATTAATGGAGATTAAGTTAGA
TAAAAAAGATCCAAGAGTTGATTCACAATTAGAACCTGATATATGGGTTGAACCTAAATATGTTGCTGAAATTATAGGTG
CAGAAATAACACTATCTCCAGAACACACGTGCTGTAAAGATATGGTGTCTAAAGGTGCAGGGTTATCAGTAAGATTTCCT
AGATTTATAAGATGGAGGGATGATAAAAGCATAGAAGATGCTACAACTCCTAAAGAAATTTACGAAATGTATAAAATGAA
ATTGAGAAAGAAGGAAGAAGAACAGCACACTGATGAAGCATAA

Upstream 100 bases:

>100_bases
GTAACTCTGAGTCTTCATCTATCTGAAATGCCGGGTTTTCATCACTGTATTATATCGTCAAAGCTATAAATATAAAAGTT
AAGCTAAAATATTTTAAAGT

Downstream 100 bases:

>100_bases
GGGATTATAAAACTAAACTTCAAATACTTCTTTTTCCTAAAATAGATAGTGTTTGATATACTAGATAATGGTGCCATTTT
ATTAGGCAACAATTTTACTA

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MEFKLIAEYFDKLEKISSRLQLTALLTDLFKKADKNVIDKVVYLIQGKLWPDFLGYPELGVGEKLLIKAISIAVNVKEEV
VEEQLKVVGDLGEVAMRLKKTPQSASILSFLGAQSNEGLTVEETYESLTKIALASGEGSRDIKIRSLAGLLKKASPLEAK
YIVRFVDGRLRVGIGDATIMDALSTAFTGSTSFRPLIERAYNLRADLGNIAKIIAQQGVEALKDIKPQVGIPIRPMLAER
MSDPAEILAKVGGEALVDYKYDGERAQIHKKDKEVYIFSRRLENITRMYPDVVEYVREYINANEVIIEGEIVAVDPESNE
IRPFQELMHRKRKNDINEAIKEYPVNVYLFDLMLYEDADYTMKPLPERRKKLEEVIKPNDKLHIAHHIYTNNVDKLMEFF
YDAISNGAEGVMVKSVAKDSIYQAGSRGFLWIKLKRDYQSEMADSVDLVVVGAFYGRGKRGGKLSSLLMAAYDPETDTFK
TVCKVASGFSDAELDELQKKLMEIKLDKKDPRVDSQLEPDIWVEPKYVAEIIGAEITLSPEHTCCKDMVSKGAGLSVRFP
RFIRWRDDKSIEDATTPKEIYEMYKMKLRKKEEEQHTDEA

Sequences:

>Translated_600_residues
MEFKLIAEYFDKLEKISSRLQLTALLTDLFKKADKNVIDKVVYLIQGKLWPDFLGYPELGVGEKLLIKAISIAVNVKEEV
VEEQLKVVGDLGEVAMRLKKTPQSASILSFLGAQSNEGLTVEETYESLTKIALASGEGSRDIKIRSLAGLLKKASPLEAK
YIVRFVDGRLRVGIGDATIMDALSTAFTGSTSFRPLIERAYNLRADLGNIAKIIAQQGVEALKDIKPQVGIPIRPMLAER
MSDPAEILAKVGGEALVDYKYDGERAQIHKKDKEVYIFSRRLENITRMYPDVVEYVREYINANEVIIEGEIVAVDPESNE
IRPFQELMHRKRKNDINEAIKEYPVNVYLFDLMLYEDADYTMKPLPERRKKLEEVIKPNDKLHIAHHIYTNNVDKLMEFF
YDAISNGAEGVMVKSVAKDSIYQAGSRGFLWIKLKRDYQSEMADSVDLVVVGAFYGRGKRGGKLSSLLMAAYDPETDTFK
TVCKVASGFSDAELDELQKKLMEIKLDKKDPRVDSQLEPDIWVEPKYVAEIIGAEITLSPEHTCCKDMVSKGAGLSVRFP
RFIRWRDDKSIEDATTPKEIYEMYKMKLRKKEEEQHTDEA
>Mature_600_residues
MEFKLIAEYFDKLEKISSRLQLTALLTDLFKKADKNVIDKVVYLIQGKLWPDFLGYPELGVGEKLLIKAISIAVNVKEEV
VEEQLKVVGDLGEVAMRLKKTPQSASILSFLGAQSNEGLTVEETYESLTKIALASGEGSRDIKIRSLAGLLKKASPLEAK
YIVRFVDGRLRVGIGDATIMDALSTAFTGSTSFRPLIERAYNLRADLGNIAKIIAQQGVEALKDIKPQVGIPIRPMLAER
MSDPAEILAKVGGEALVDYKYDGERAQIHKKDKEVYIFSRRLENITRMYPDVVEYVREYINANEVIIEGEIVAVDPESNE
IRPFQELMHRKRKNDINEAIKEYPVNVYLFDLMLYEDADYTMKPLPERRKKLEEVIKPNDKLHIAHHIYTNNVDKLMEFF
YDAISNGAEGVMVKSVAKDSIYQAGSRGFLWIKLKRDYQSEMADSVDLVVVGAFYGRGKRGGKLSSLLMAAYDPETDTFK
TVCKVASGFSDAELDELQKKLMEIKLDKKDPRVDSQLEPDIWVEPKYVAEIIGAEITLSPEHTCCKDMVSKGAGLSVRFP
RFIRWRDDKSIEDATTPKEIYEMYKMKLRKKEEEQHTDEA

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family

Homologues:

Organism=Homo sapiens, GI4557719, Length=617, Percent_Identity=32.2528363047002, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI73747829, Length=497, Percent_Identity=31.1871227364185, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI73747844, Length=495, Percent_Identity=31.3131313131313, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI46255052, Length=484, Percent_Identity=26.8595041322314, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI23199993, Length=484, Percent_Identity=26.8595041322314, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148539894, Length=484, Percent_Identity=26.8595041322314, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71985269, Length=610, Percent_Identity=35.2459016393443, Blast_Score=344, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI71985278, Length=188, Percent_Identity=30.8510638297872, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71981465, Length=408, Percent_Identity=24.5098039215686, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320038, Length=612, Percent_Identity=34.3137254901961, Blast_Score=316, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6324578, Length=521, Percent_Identity=23.2245681381958, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24762424, Length=625, Percent_Identity=32.64, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI85815841, Length=569, Percent_Identity=30.4042179261863, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24641829, Length=512, Percent_Identity=23.6328125, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNLI_SULTO (Q976G4)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376074.1
- ProteinModelPortal:   Q976G4
- SMR:   Q976G4
- GeneID:   1458113
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0223
- NMPDR:   fig|273063.1.peg.242
- HOGENOM:   HBG570821
- OMA:   EYQSICK
- ProtClustDB:   PRK01109
- BioCyc:   STOK273063:ST0223-MONOMER
- BRENDA:   6.5.1.1
- HAMAP:   MF_00407
- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027
- Gene3D:   G3DSA:2.40.50.140
- TIGRFAMs:   TIGR00574

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N; SSF50249 Nucleic_acid_OB

EC number: =6.5.1.1

Molecular weight: Translated: 68026; Mature: 68026

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00697 DNA_LIGASE_A1; PS00333 DNA_LIGASE_A2; PS50160 DNA_LIGASE_A3

Important sites: ACT_SITE 260-260 BINDING 258-258 BINDING 265-265 BINDING 280-280 BINDING 310-310 BINDING 350-350 BINDING 427-427 BINDING 433-433

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MEFKLIAEYFDKLEKISSRLQLTALLTDLFKKADKNVIDKVVYLIQGKLWPDFLGYPELG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
VGEKLLIKAISIAVNVKEEVVEEQLKVVGDLGEVAMRLKKTPQSASILSFLGAQSNEGLT
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
VEETYESLTKIALASGEGSRDIKIRSLAGLLKKASPLEAKYIVRFVDGRLRVGIGDATIM
HHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHCCEEEEECCHHHHH
DALSTAFTGSTSFRPLIERAYNLRADLGNIAKIIAQQGVEALKDIKPQVGIPIRPMLAER
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
MSDPAEILAKVGGEALVDYKYDGERAQIHKKDKEVYIFSRRLENITRMYPDVVEYVREYI
CCCHHHHHHHCCCCEEEEEEECCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHC
NANEVIIEGEIVAVDPESNEIRPFQELMHRKRKNDINEAIKEYPVNVYLFDLMLYEDADY
CCCEEEEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCC
TMKPLPERRKKLEEVIKPNDKLHIAHHIYTNNVDKLMEFFYDAISNGAEGVMVKSVAKDS
CCCCCHHHHHHHHHHHCCCCCEEEEEEEHHCCHHHHHHHHHHHHCCCCCCEEHHHHHHHH
IYQAGSRGFLWIKLKRDYQSEMADSVDLVVVGAFYGRGKRGGKLSSLLMAAYDPETDTFK
HHHCCCCCEEEEEECCHHHHHHHCCCCEEEEEEHHCCCCCCCHHHHHHHHHCCCCCHHHH
TVCKVASGFSDAELDELQKKLMEIKLDKKDPRVDSQLEPDIWVEPKYVAEIIGAEITLSP
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECC
EHTCCKDMVSKGAGLSVRFPRFIRWRDDKSIEDATTPKEIYEMYKMKLRKKEEEQHTDEA
CHHHHHHHHHCCCCCEEECCHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFKLIAEYFDKLEKISSRLQLTALLTDLFKKADKNVIDKVVYLIQGKLWPDFLGYPELG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
VGEKLLIKAISIAVNVKEEVVEEQLKVVGDLGEVAMRLKKTPQSASILSFLGAQSNEGLT
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
VEETYESLTKIALASGEGSRDIKIRSLAGLLKKASPLEAKYIVRFVDGRLRVGIGDATIM
HHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHCCEEEEECCHHHHH
DALSTAFTGSTSFRPLIERAYNLRADLGNIAKIIAQQGVEALKDIKPQVGIPIRPMLAER
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
MSDPAEILAKVGGEALVDYKYDGERAQIHKKDKEVYIFSRRLENITRMYPDVVEYVREYI
CCCHHHHHHHCCCCEEEEEEECCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHC
NANEVIIEGEIVAVDPESNEIRPFQELMHRKRKNDINEAIKEYPVNVYLFDLMLYEDADY
CCCEEEEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCC
TMKPLPERRKKLEEVIKPNDKLHIAHHIYTNNVDKLMEFFYDAISNGAEGVMVKSVAKDS
CCCCCHHHHHHHHHHHCCCCCEEEEEEEHHCCHHHHHHHHHHHHCCCCCCEEHHHHHHHH
IYQAGSRGFLWIKLKRDYQSEMADSVDLVVVGAFYGRGKRGGKLSSLLMAAYDPETDTFK
HHHCCCCCEEEEEECCHHHHHHHCCCCEEEEEEHHCCCCCCCHHHHHHHHHCCCCCHHHH
TVCKVASGFSDAELDELQKKLMEIKLDKKDPRVDSQLEPDIWVEPKYVAEIIGAEITLSP
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECC
EHTCCKDMVSKGAGLSVRFPRFIRWRDDKSIEDATTPKEIYEMYKMKLRKKEEEQHTDEA
CHHHHHHHHHCCCCCEEECCHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479