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The map label for this gene is maeB [C]

Identifier: 15920293

GI number: 15920293

Start: 135353

End: 136597

Strand: Reverse

Name: maeB [C]

Synonym: ST0114

Alternate gene names: 15920293

Gene position: 136597-135353 (Counterclockwise)

Preceding gene: 15920297

Following gene: 15920292

Centisome position: 5.07

GC content: 35.18

Gene sequence:

>1245_bases
ATGGCAATATCATTAGCTAAGAAATACCAAGGGAAATTAGAGATAATGCCTAAAATTCCCATTAGATCTTACGAAGATTT
CGCTTTAATCTACACACCCGGAGTAGCAGAACTAGTTAAAGAAATACAGAAGGATGAAAACCAAAGTTTTGAGCTAACCA
GCAGATGGAATACCATAGCAATTTTAACAGATGGTAGCAGAGTATTAGGATTAGGCAATGTTGGGCCTATCGCTTCTCTA
CCCGTAATGGAAGGAAAAGCTTTGTTATTTAAATTTCTAGGGGGTGTTGATGCTTTTCCTTTGCCTATAAAAGTTTCAGA
TAAGGAGGAATTTATACAAGTCGCTAAAGCAATAGAACCAGCTTTTGGCGGAATAAATTTAGAAGATATTGAGTCTCCAA
AATGTTTCTTTATATTGGAAGAACTTCAAAAAACTCTAAATATACCAGTATGGCATGATGATCAGCAAGGTACAGCTGGT
GCTGTCCTCGCTGGTTTAATTAACGCAATAAAAATTACTGGCAAAGATAAGAATTCTAAAATAGTCCTTATGGGTGCTGG
AGCTGCAAACATAGCAACCGCACAATTATTAATTAAATATGGTTTTAACCCTAAGAATATGATTTTAATAGATAAAGAAG
GACCGCTATATGCCGAAAGAGGGGATGTTGATTCTTTAATGTTTAAACATCCATGGAAATATGAGTTAGCCATACAGACA
AACAGTGAAAGAGTAAAAACAATTGAGGAAGCATTTAAAGGTGCAGATATCCTAATTGCTGCTTCTTCACCAGAAGTTAG
AATAGATAAAAAACTAATTAGAATGATGAATAAGCCTATAGTATTTGCATTAGCAAATCCAATTCCAGAGATATATCCCA
ATGAAGCCAAAGAAGCTGGTGCAGTAATTGTAGCAACAGGAAGGAGTGACTTCCCGAATCAGGTAAATAATTCTCTAATA
TTTCCAGCAGTATTTAGAGGAGTATTAGACAGTAGAGCAAAGAAAATCACTGACGAGATGATAATAGCTGCTGCAGAAGA
ACTTGCCAAATATGCTGAAGAGAAAGGTCTAAGAGAAGATTATATTATTCCAAGAATGGATGAGATAGAAGTATACTATA
GAATGGCTGCTGCAGTAGCTACTAAAGCAGTAGAATTAGGTTATGCTAGACTAAAATTATCTTATCGTGAATTTTTAGAA
TCTGCTAAAGAAAGAATTCTAAGAGCTAGGAGGTTGAGTTTATGA

Upstream 100 bases:

>100_bases
AGTTTTTCCCATATTCTTTTAAAAACTAAAATAATAAGAATTTTCATTCATTTCACGATTTGAGGAAAATTTTAAAAATA
CATAAAGTTTAGAATTATTT

Downstream 100 bases:

>100_bases
TAAGAAAAGCAATTGAAAAAGATATAGAAGTATTAACAGATATGTTTGCTAGAATGTATAGATTAAACGCGGAATTTGAT
CCTCTACTGGAAGTTCCTCA

Product: malate oxidoreductase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAISLAKKYQGKLEIMPKIPIRSYEDFALIYTPGVAELVKEIQKDENQSFELTSRWNTIAILTDGSRVLGLGNVGPIASL
PVMEGKALLFKFLGGVDAFPLPIKVSDKEEFIQVAKAIEPAFGGINLEDIESPKCFFILEELQKTLNIPVWHDDQQGTAG
AVLAGLINAIKITGKDKNSKIVLMGAGAANIATAQLLIKYGFNPKNMILIDKEGPLYAERGDVDSLMFKHPWKYELAIQT
NSERVKTIEEAFKGADILIAASSPEVRIDKKLIRMMNKPIVFALANPIPEIYPNEAKEAGAVIVATGRSDFPNQVNNSLI
FPAVFRGVLDSRAKKITDEMIIAAAEELAKYAEEKGLREDYIIPRMDEIEVYYRMAAAVATKAVELGYARLKLSYREFLE
SAKERILRARRLSL

Sequences:

>Translated_414_residues
MAISLAKKYQGKLEIMPKIPIRSYEDFALIYTPGVAELVKEIQKDENQSFELTSRWNTIAILTDGSRVLGLGNVGPIASL
PVMEGKALLFKFLGGVDAFPLPIKVSDKEEFIQVAKAIEPAFGGINLEDIESPKCFFILEELQKTLNIPVWHDDQQGTAG
AVLAGLINAIKITGKDKNSKIVLMGAGAANIATAQLLIKYGFNPKNMILIDKEGPLYAERGDVDSLMFKHPWKYELAIQT
NSERVKTIEEAFKGADILIAASSPEVRIDKKLIRMMNKPIVFALANPIPEIYPNEAKEAGAVIVATGRSDFPNQVNNSLI
FPAVFRGVLDSRAKKITDEMIIAAAEELAKYAEEKGLREDYIIPRMDEIEVYYRMAAAVATKAVELGYARLKLSYREFLE
SAKERILRARRLSL
>Mature_413_residues
AISLAKKYQGKLEIMPKIPIRSYEDFALIYTPGVAELVKEIQKDENQSFELTSRWNTIAILTDGSRVLGLGNVGPIASLP
VMEGKALLFKFLGGVDAFPLPIKVSDKEEFIQVAKAIEPAFGGINLEDIESPKCFFILEELQKTLNIPVWHDDQQGTAGA
VLAGLINAIKITGKDKNSKIVLMGAGAANIATAQLLIKYGFNPKNMILIDKEGPLYAERGDVDSLMFKHPWKYELAIQTN
SERVKTIEEAFKGADILIAASSPEVRIDKKLIRMMNKPIVFALANPIPEIYPNEAKEAGAVIVATGRSDFPNQVNNSLIF
PAVFRGVLDSRAKKITDEMIIAAAEELAKYAEEKGLREDYIIPRMDEIEVYYRMAAAVATKAVELGYARLKLSYREFLES
AKERILRARRLSL

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=396, Percent_Identity=25.5050505050505, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI62420880, Length=396, Percent_Identity=25.5050505050505, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI239049447, Length=396, Percent_Identity=25.5050505050505, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4505143, Length=383, Percent_Identity=26.3707571801567, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4505145, Length=418, Percent_Identity=26.0765550239234, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788806, Length=395, Percent_Identity=40, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI87081919, Length=478, Percent_Identity=27.4058577405858, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17537199, Length=387, Percent_Identity=28.1653746770026, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281362674, Length=435, Percent_Identity=28.5057471264368, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281362672, Length=435, Percent_Identity=28.5057471264368, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356279, Length=435, Percent_Identity=28.5057471264368, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI78707242, Length=416, Percent_Identity=26.9230769230769, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78707238, Length=416, Percent_Identity=26.9230769230769, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78707240, Length=437, Percent_Identity=26.5446224256293, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646388, Length=439, Percent_Identity=24.8291571753986, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646386, Length=439, Percent_Identity=24.8291571753986, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 45922; Mature: 45791

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISLAKKYQGKLEIMPKIPIRSYEDFALIYTPGVAELVKEIQKDENQSFELTSRWNTIA
CCCCCCHHCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCEEE
ILTDGSRVLGLGNVGPIASLPVMEGKALLFKFLGGVDAFPLPIKVSDKEEFIQVAKAIEP
EEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHH
AFGGINLEDIESPKCFFILEELQKTLNIPVWHDDQQGTAGAVLAGLINAIKITGKDKNSK
HHCCCCHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHEEEECCCCCCE
IVLMGAGAANIATAQLLIKYGFNPKNMILIDKEGPLYAERGDVDSLMFKHPWKYELAIQT
EEEEECCCCHHHHHHHHHEECCCCCCEEEEECCCCCEECCCCHHHHHHCCCCEEEEEEEC
NSERVKTIEEAFKGADILIAASSPEVRIDKKLIRMMNKPIVFALANPIPEIYPNEAKEAG
CCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHCC
AVIVATGRSDFPNQVNNSLIFPAVFRGVLDSRAKKITDEMIIAAAEELAKYAEEKGLRED
EEEEEECCCCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YIIPRMDEIEVYYRMAAAVATKAVELGYARLKLSYREFLESAKERILRARRLSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AISLAKKYQGKLEIMPKIPIRSYEDFALIYTPGVAELVKEIQKDENQSFELTSRWNTIA
CCCCCHHCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCEEE
ILTDGSRVLGLGNVGPIASLPVMEGKALLFKFLGGVDAFPLPIKVSDKEEFIQVAKAIEP
EEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHH
AFGGINLEDIESPKCFFILEELQKTLNIPVWHDDQQGTAGAVLAGLINAIKITGKDKNSK
HHCCCCHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHEEEECCCCCCE
IVLMGAGAANIATAQLLIKYGFNPKNMILIDKEGPLYAERGDVDSLMFKHPWKYELAIQT
EEEEECCCCHHHHHHHHHEECCCCCCEEEEECCCCCEECCCCHHHHHHCCCCEEEEEEEC
NSERVKTIEEAFKGADILIAASSPEVRIDKKLIRMMNKPIVFALANPIPEIYPNEAKEAG
CCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHCC
AVIVATGRSDFPNQVNNSLIFPAVFRGVLDSRAKKITDEMIIAAAEELAKYAEEKGLRED
EEEEEECCCCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YIIPRMDEIEVYYRMAAAVATKAVELGYARLKLSYREFLESAKERILRARRLSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]