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The map label for this gene is adh [H]

Identifier: 15920215

GI number: 15920215

Start: 56081

End: 57004

Strand: Reverse

Name: adh [H]

Synonym: ST0038

Alternate gene names: 15920215

Gene position: 57004-56081 (Counterclockwise)

Preceding gene: 15920216

Following gene: 15920212

Centisome position: 2.12

GC content: 39.07

Gene sequence:

>924_bases
GTGCGGGGGTTTGCAGAACTGATTTACATATACAAGAGGGAATTTGGAAAGGATGTATTTAATCCAAAATTACCCTTCAC
CATTGGGCATGAAAATGTAGGAATAATTGAGGAAGTTGGTAGTGCTGTGGATTGGTTAAGTAAAGGAGACCCGGTAATCC
TACATCCCTACATAACTTGTAGGCACTGCAAAGCATGTAGGGCTGGGAATGATATGCATTGTCCTAACGGTAAGTTCCCA
GGGCTTGATGGGACTGATGGAGGTTATGCTGAGTATTTAAAGACATCAGCTTATTCAGCTATAAAATTGCCTAAAAATGT
AGACCCAACACCAATGGCACCATTAGCAGATGCTGGGTTAACAGCGTATCACGCAGTAAAGAAATTAAAACTAGATCCCG
ACAGTAAGGTGGTAGTGATAGGAATAGGAGGATTGGGGCATATAGCAGTACAGATATTAAAGGCAATAACGCCGGCAACA
ATAATAGCTGTTGATGTTAGTGAGGATAGGATTAAATTAGCTAAGGAATTGGGAGCTGATGAAGGAGTAATAGCTGGAGC
TGATGGAGGAGTTAATGAGGTATTAAAGTTGACTAATAATGAGGGGGCAGATGCAGTACTGGATTTTGTAGGTGAGCATG
GTACACCTAAGAACGCTATAAGGATGATTAAAAAAGGAGGAATATATTCCATTGTGGGTTATGGTGGAGAATTTACTAAT
ACGACACTGGATTTCATCAGTAGAGAAATAAGTGTTATAGGGAATTTAGTGGGGACATATAATGAGTTAGCAGAATTAGT
TGAATTATATGCAAGAGAAAAAGTGAAATTAAGAACGCAAATGTTTAGGTTAGAGGAGGCAAATAAAGCATTAGAAATGC
TTAAGAGTGGAAAAATAGCTGGAAGAGCAATATTAGTACCGTAA

Upstream 100 bases:

>100_bases
AAGGCAGTTAGAATTCATGAATATAATGCACCCTTACAATTAGATGAAGTAGATTATCCAAAAATAACTGGGCCTTATGA
TATTATAGTAAGAATAAAGG

Downstream 100 bases:

>100_bases
TCTAGACAGCAACATCATAACATAAATCTAAGCTATTTATTTTCTTTTCTTGATCTTAATTTAACGTCTTTCTTCATGAA
GAAATAAGACTTAGTTAGAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRGFAELIYIYKREFGKDVFNPKLPFTIGHENVGIIEEVGSAVDWLSKGDPVILHPYITCRHCKACRAGNDMHCPNGKFP
GLDGTDGGYAEYLKTSAYSAIKLPKNVDPTPMAPLADAGLTAYHAVKKLKLDPDSKVVVIGIGGLGHIAVQILKAITPAT
IIAVDVSEDRIKLAKELGADEGVIAGADGGVNEVLKLTNNEGADAVLDFVGEHGTPKNAIRMIKKGGIYSIVGYGGEFTN
TTLDFISREISVIGNLVGTYNELAELVELYAREKVKLRTQMFRLEEANKALEMLKSGKIAGRAILVP

Sequences:

>Translated_307_residues
MRGFAELIYIYKREFGKDVFNPKLPFTIGHENVGIIEEVGSAVDWLSKGDPVILHPYITCRHCKACRAGNDMHCPNGKFP
GLDGTDGGYAEYLKTSAYSAIKLPKNVDPTPMAPLADAGLTAYHAVKKLKLDPDSKVVVIGIGGLGHIAVQILKAITPAT
IIAVDVSEDRIKLAKELGADEGVIAGADGGVNEVLKLTNNEGADAVLDFVGEHGTPKNAIRMIKKGGIYSIVGYGGEFTN
TTLDFISREISVIGNLVGTYNELAELVELYAREKVKLRTQMFRLEEANKALEMLKSGKIAGRAILVP
>Mature_307_residues
MRGFAELIYIYKREFGKDVFNPKLPFTIGHENVGIIEEVGSAVDWLSKGDPVILHPYITCRHCKACRAGNDMHCPNGKFP
GLDGTDGGYAEYLKTSAYSAIKLPKNVDPTPMAPLADAGLTAYHAVKKLKLDPDSKVVVIGIGGLGHIAVQILKAITPAT
IIAVDVSEDRIKLAKELGADEGVIAGADGGVNEVLKLTNNEGADAVLDFVGEHGTPKNAIRMIKKGGIYSIVGYGGEFTN
TTLDFISREISVIGNLVGTYNELAELVELYAREKVKLRTQMFRLEEANKALEMLKSGKIAGRAILVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=295, Percent_Identity=27.4576271186441, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71565154, Length=310, Percent_Identity=28.7096774193548, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4501929, Length=316, Percent_Identity=28.4810126582279, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI34577061, Length=308, Percent_Identity=28.8961038961039, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501933, Length=310, Percent_Identity=28.3870967741935, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI156523966, Length=313, Percent_Identity=27.1565495207668, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4501939, Length=305, Percent_Identity=26.8852459016393, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI71743840, Length=308, Percent_Identity=25.974025974026, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI262073058, Length=308, Percent_Identity=25.974025974026, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI71565152, Length=321, Percent_Identity=25.8566978193146, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=290, Percent_Identity=32.4137931034483, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788073, Length=233, Percent_Identity=28.755364806867, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082125, Length=289, Percent_Identity=28.719723183391, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=25.9515570934256, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788407, Length=298, Percent_Identity=26.1744966442953, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082401, Length=297, Percent_Identity=29.96632996633, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790718, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788075, Length=283, Percent_Identity=28.2685512367491, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI226510992, Length=253, Percent_Identity=26.4822134387352, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786518, Length=294, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787863, Length=285, Percent_Identity=24.2105263157895, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=343, Percent_Identity=25.6559766763848, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=289, Percent_Identity=26.2975778546713, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=289, Percent_Identity=25.6055363321799, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=287, Percent_Identity=27.8745644599303, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=290, Percent_Identity=26.551724137931, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=285, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=301, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=294, Percent_Identity=28.2312925170068, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323961, Length=288, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=287, Percent_Identity=25.0871080139373, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=295, Percent_Identity=27.7966101694915, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=295, Percent_Identity=27.7966101694915, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=276, Percent_Identity=28.6231884057971, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=174, Percent_Identity=30.4597701149425, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=313, Percent_Identity=25.2396166134185, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=267, Percent_Identity=24.7191011235955, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=294, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=283, Percent_Identity=27.5618374558304, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17737897, Length=280, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 33052; Mature: 33052

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGFAELIYIYKREFGKDVFNPKLPFTIGHENVGIIEEVGSAVDWLSKGDPVILHPYITC
CCHHHHHHHHHHHHHCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCHHH
RHCKACRAGNDMHCPNGKFPGLDGTDGGYAEYLKTSAYSAIKLPKNVDPTPMAPLADAGL
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHEEECCCCCCCCCCCCHHHCCH
TAYHAVKKLKLDPDSKVVVIGIGGLGHIAVQILKAITPATIIAVDVSEDRIKLAKELGAD
HHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCC
EGVIAGADGGVNEVLKLTNNEGADAVLDFVGEHGTPKNAIRMIKKGGIYSIVGYGGEFTN
CCEEECCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCH
TTLDFISREISVIGNLVGTYNELAELVELYAREKVKLRTQMFRLEEANKALEMLKSGKIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GRAILVP
CEEEECC
>Mature Secondary Structure
MRGFAELIYIYKREFGKDVFNPKLPFTIGHENVGIIEEVGSAVDWLSKGDPVILHPYITC
CCHHHHHHHHHHHHHCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCHHH
RHCKACRAGNDMHCPNGKFPGLDGTDGGYAEYLKTSAYSAIKLPKNVDPTPMAPLADAGL
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHEEECCCCCCCCCCCCHHHCCH
TAYHAVKKLKLDPDSKVVVIGIGGLGHIAVQILKAITPATIIAVDVSEDRIKLAKELGAD
HHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCC
EGVIAGADGGVNEVLKLTNNEGADAVLDFVGEHGTPKNAIRMIKKGGIYSIVGYGGEFTN
CCEEECCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCH
TTLDFISREISVIGNLVGTYNELAELVELYAREKVKLRTQMFRLEEANKALEMLKSGKIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GRAILVP
CEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA