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The map label for this gene is proA

Identifier: 159185378

GI number: 159185378

Start: 2783532

End: 2784773

Strand: Reverse

Name: proA

Synonym: Atu2779

Alternate gene names: 159185378

Gene position: 2784773-2783532 (Counterclockwise)

Preceding gene: 15890029

Following gene: 159185377

Centisome position: 98.0

GC content: 62.64

Gene sequence:

>1242_bases
ATGATGACCATCGGCGCTCAGGCGAAAGCTGCTTCGCGACCGTTGTCCATCGCCGGCACGGACCAGAAGAACCGTGCGCT
GCTTGCCATGGCATCTGCCATTGAGGCTTCGAAGGAGGCGATCCTTGCCGCCAACCGCAAAGATCTGGCGGCTGCGGAAA
GCGCCGGCCTTGCCGCTTCGTTCGTCGACAGGCTGACACTCAACGATGCGCGCATCGCCGGCATTGCCGAAGGCATCCGC
TCGGTTGCCGCGCTGGCCGATCCGGTGGGTGAAGTCATCGCCGCCTGGGATCGCCCCAACGGGCTGAAAATCGAGCGCGT
GCGCACGCCGCTCGGCGTTATCGGCGTGATCTACGAAAGCCGCCCGAATGTGACGGCGGATGCGGGCGCGCTGTGCCTCA
AGGCCGGCAACGCCGTGATCCTGCGCGGCGGCTCGGATTCGCAACATTCATCGCGTGCTATCCATGCCTGTCTCGTGCAG
GGCCTGAGGATCGCCGGTCTTCCGGAGAATGCCATTCAACTCGTGCCGGTAACCGACCGCGCGGCTGTCGGCGCTCTTCT
CAGCGGGCTTAAAGGTACGGTCGATGTCATCGTGCCGCGCGGCGGCAAAAGCCTGGTGGCGCGGGTGCAGTCTGAAGCCC
GTGTGCCGGTCTTCGCGCATCTGGAAGGCATCTGCCATATCTATGTCGACAAATCCGCTGATCTCGACATGGCAAAAGCC
ATCGTCGTGAATGCGAAGATGCGCCGCACCGGCATTTGCGGGGCGGCCGAAACCCTGCTGGTGGATGCGTCTGCCGTCTC
CAGTCATCTCGAGCCAGTCGTCAAAGCCCTGCTTGACGCGGGTTGCGAAGTACGTGGTTCGCAGCCGGTTCGTAATGTGG
TTGAGGGGCTGGAGGCCGCTACGGAAGAGGACTGGCGCACCGAATATCTCGATGCGATCATTTCGGTCGCCGTGGTGGAT
GGCATTTCCGGCGCGATCGAGCATATCGGCACCTATTCGTCCAATCATACCGAGGCGGTGATCGCCGAGGACCCGGATGT
GGTCGCGCGGTTTTTCAACGAACTCGATTCGGCCATTCTGCTGCACAATGCCTCGACGCAATTTGCCGATGGCGGCGAAT
TCGGCATGGGCGCGGAAATTGGCATCGCCACCGGCAAGATGCATGCGCGGGGCCCTGTCGGCGTCGAGCAGCTCACCTCG
TTTAAATACCGTGTGCATGGCACCGGCCAGACACGGACCTGA

Upstream 100 bases:

>100_bases
CTTGTGATGACTGGCGCTGCCGTCAAAGTGAAACATGCAAAGAAGGATGAGGTCCATGCCTGAACAGGCCGTGAAGCAGA
GCCATGATATCGATGCGCTG

Downstream 100 bases:

>100_bases
TATTTGCCGGCCGATAAGCGCCTCGACAGACGTTATCTCGCCATGCCGCACGTGGAGCGCGGCATGGTCGTCGGGCTTTT
CGGCGGCTCCTTCAATCCGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MMTIGAQAKAASRPLSIAGTDQKNRALLAMASAIEASKEAILAANRKDLAAAESAGLAASFVDRLTLNDARIAGIAEGIR
SVAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSQHSSRAIHACLVQ
GLRIAGLPENAIQLVPVTDRAAVGALLSGLKGTVDVIVPRGGKSLVARVQSEARVPVFAHLEGICHIYVDKSADLDMAKA
IVVNAKMRRTGICGAAETLLVDASAVSSHLEPVVKALLDAGCEVRGSQPVRNVVEGLEAATEEDWRTEYLDAIISVAVVD
GISGAIEHIGTYSSNHTEAVIAEDPDVVARFFNELDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTS
FKYRVHGTGQTRT

Sequences:

>Translated_413_residues
MMTIGAQAKAASRPLSIAGTDQKNRALLAMASAIEASKEAILAANRKDLAAAESAGLAASFVDRLTLNDARIAGIAEGIR
SVAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSQHSSRAIHACLVQ
GLRIAGLPENAIQLVPVTDRAAVGALLSGLKGTVDVIVPRGGKSLVARVQSEARVPVFAHLEGICHIYVDKSADLDMAKA
IVVNAKMRRTGICGAAETLLVDASAVSSHLEPVVKALLDAGCEVRGSQPVRNVVEGLEAATEEDWRTEYLDAIISVAVVD
GISGAIEHIGTYSSNHTEAVIAEDPDVVARFFNELDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTS
FKYRVHGTGQTRT
>Mature_413_residues
MMTIGAQAKAASRPLSIAGTDQKNRALLAMASAIEASKEAILAANRKDLAAAESAGLAASFVDRLTLNDARIAGIAEGIR
SVAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSQHSSRAIHACLVQ
GLRIAGLPENAIQLVPVTDRAAVGALLSGLKGTVDVIVPRGGKSLVARVQSEARVPVFAHLEGICHIYVDKSADLDMAKA
IVVNAKMRRTGICGAAETLLVDASAVSSHLEPVVKALLDAGCEVRGSQPVRNVVEGLEAATEEDWRTEYLDAIISVAVVD
GISGAIEHIGTYSSNHTEAVIAEDPDVVARFFNELDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTS
FKYRVHGTGQTRT

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=411, Percent_Identity=35.5231143552311, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI21361368, Length=411, Percent_Identity=35.5231143552311, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1786438, Length=409, Percent_Identity=40.8312958435208, Blast_Score=311, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=33.8129496402878, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=33.8129496402878, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=35.5140186915888, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=34.8039215686275, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_AGRT5 (Q8UBS1)

Other databases:

- EMBL:   AE007869
- PIR:   AB2918
- PIR:   E97692
- RefSeq:   NP_355709.2
- ProteinModelPortal:   Q8UBS1
- SMR:   Q8UBS1
- STRING:   Q8UBS1
- GeneID:   1134817
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2779
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   ATUM176299-1:ATU2779-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 42967; Mature: 42967

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTIGAQAKAASRPLSIAGTDQKNRALLAMASAIEASKEAILAANRKDLAAAESAGLAAS
CCCCCCCCHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHH
FVDRLTLNDARIAGIAEGIRSVAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIYES
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEC
RPNVTADAGALCLKAGNAVILRGGSDSQHSSRAIHACLVQGLRIAGLPENAIQLVPVTDR
CCCCCCCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCEECCCCCCCEEEEECCCH
AAVGALLSGLKGTVDVIVPRGGKSLVARVQSEARVPVFAHLEGICHIYVDKSADLDMAKA
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCHHHHH
IVVNAKMRRTGICGAAETLLVDASAVSSHLEPVVKALLDAGCEVRGSQPVRNVVEGLEAA
HHHCCHHHHCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TEEDWRTEYLDAIISVAVVDGISGAIEHIGTYSSNHTEAVIAEDPDVVARFFNELDSAIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCEEE
LHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVHGTGQTRT
EECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEEECCCCCCC
>Mature Secondary Structure
MMTIGAQAKAASRPLSIAGTDQKNRALLAMASAIEASKEAILAANRKDLAAAESAGLAAS
CCCCCCCCHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHH
FVDRLTLNDARIAGIAEGIRSVAALADPVGEVIAAWDRPNGLKIERVRTPLGVIGVIYES
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEC
RPNVTADAGALCLKAGNAVILRGGSDSQHSSRAIHACLVQGLRIAGLPENAIQLVPVTDR
CCCCCCCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCEECCCCCCCEEEEECCCH
AAVGALLSGLKGTVDVIVPRGGKSLVARVQSEARVPVFAHLEGICHIYVDKSADLDMAKA
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCHHHHH
IVVNAKMRRTGICGAAETLLVDASAVSSHLEPVVKALLDAGCEVRGSQPVRNVVEGLEAA
HHHCCHHHHCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TEEDWRTEYLDAIISVAVVDGISGAIEHIGTYSSNHTEAVIAEDPDVVARFFNELDSAIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCEEE
LHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVHGTGQTRT
EECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194