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The map label for this gene is mclA [H]

Identifier: 159184976

GI number: 159184976

Start: 1888309

End: 1890123

Strand: Reverse

Name: mclA [H]

Synonym: Atu1912

Alternate gene names: 159184976

Gene position: 1890123-1888309 (Counterclockwise)

Preceding gene: 15889208

Following gene: 159184975

Centisome position: 66.52

GC content: 61.93

Gene sequence:

>1815_bases
ATGAAAAACGTAACAATCTCTATGCGCCTTTATGCGCTCGTCGCATTGTTTCTGGCAATACTGGCCGCGGCTCTCACATT
CAGCTTGTTTGAAAGTTATCGTGAGATGGAGCGCGAGCGCAAAGCCGGGCTGGCAGCGATGAACGAGACGGCCGTCGCCA
TTATCAAGCAATATTACCAGCTGGAGCAGGGCGGAAGCCTGACGCGGGAGGCGGCGCAGCAGCAGGCGAAAACAACGATC
GCGGCGATGCGTTATGGCAACGGCAGCGGTTATTTCTGGATTAATGACATGCATCCCACCATGGTGATGCACCCGATCAA
GCCTGAAATGAATGGCACGGACCTCACCGCTAACAAGGATCCGAACGGCAAGGCGCTGTTCGTGGAATTCGTGAATACGG
TGAAGGCGGGCGGTCAGGGTTTTGTCGATTATTACTGGCCGAAGCCCGGTGCACCGGATCCGGTCGAGAAATTTTCCCAC
GTCGCTGGCTTCGCCCCCTGGGGCTGGATTGTCGGCACCGGCGTTTATGTCGATGACCTCGAGGCTGTATTCTGGCGTGA
CGCGTATTTTAACGGCGGCCTTTGTGTCGTGGTGGGCCTTCTGGTCGTTGGCGTCGCCGCCTTCGTGGTGCGCAGCGTGA
CGCGGCCGATCGATCTTATCCGCCAGAGCATGAAGCGGATCGCCGACGGTGACGGCGCGGCCGAAATCCAGTTTGCCGAC
CGCGGCGATGAAATCGGTGCGATTGCCAAAACACTTCTGGTATTGCGTGACAGCGTCAATGAACGCAGCGCGCTGCAGGC
CCGCGAGGCCGATCAGCAGCGGGCGCTGGAGGAGGCGCGACACGGCAACGAGATGGTTCTGCGTTCCGCATCCGAGCGCC
AGGCCCATGCCATGGAGCGGCTTGGCCATGCGCTCGAGGCGCTGGCCAATGGCGATCTGACGGTCGAGCTTGCCGATATA
GGCTCGGACTATGAAAAACTGCGTGTGGATTTCAATCGTGCCGTCGGCGCGCTGCATGGCGCGATCGAGGCGATTGCGAG
AACCGGCCAAGTCGTCAATGACAGCGCCTCCGACATCAGCGGCGCGACCGGCAATCTTTCCCGCCGCACCGAACAGCAGG
CGGCGGCGCTGGAAGAGACGGCGGCCGCTCTCGATGAGATCACCGCGACGGTACGCACCGCCTCCGAGCGTGCCAATGAA
GCCCGGCAGATGGTGCAGGACACAAAAACCAGTGCCGGCCGTTCGGGTGAGATCGTCCGCAATGCCGTCGATGCCATGGG
ACGTATCGAGGATTCGTCGAAACGTATCGGTCAGATCATCTCGGTCATCGACGAAATCGCTTTCCAGACCAACCTGCTGG
CGCTGAATGCCGGTGTCGAGGCGGCGCGTGCCGGCGAGGCGGGGCGCGGTTTTGCGGTGGTGGCGCAGGAGGTGCGTGAA
CTGGCGCAACGCTCTGCCAATGCCGCCAAGGAGATCAAGACCCTTATCAACCGCTCGGCCGAGGAAGTGGGCGGTGGCGT
CGCGCTGGTGCGTTCCACCGGCGATGCGCTGGACGAGATCGTGGCGCTGGTCAACCGCGTCGATGGCCATGTCAATTCCA
TCGCCACGGCGGCGCGGGAACAGGCGACCGGCCTGCAGGAGATCAACACCTCCGTCAACCACATGGATCAGATGACCCAG
CAGAATGCCGCCATGGTGGAAGAAACGACGGCGGCGAGCCAGACGCTCGCCGAAGAAAGCCAGCAGCTGCGGGCGCTGCT
TTCACGCTTCGAACTGGGGCAGGGCGCAGGACGCGCGGTTTCGCGGGCGGCTTGA

Upstream 100 bases:

>100_bases
ATGGAATAAGACCATCGTATAATATTCGTATTTAATAATAATAAATTTCTTGCCTTTAACATCGGCTGGTCGAAGTGCAT
TCGGCGATGTTGGGGGGAAC

Downstream 100 bases:

>100_bases
TTTGATCCGTTTTTCAATAAGTGGAGGGCGTGGCTTTGGTTGCGCCCTTTGCGTGTTGACGGACCTTCACCCACACTCGA
CGTCATCCTCGGGCTGGTCC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MKNVTISMRLYALVALFLAILAAALTFSLFESYREMERERKAGLAAMNETAVAIIKQYYQLEQGGSLTREAAQQQAKTTI
AAMRYGNGSGYFWINDMHPTMVMHPIKPEMNGTDLTANKDPNGKALFVEFVNTVKAGGQGFVDYYWPKPGAPDPVEKFSH
VAGFAPWGWIVGTGVYVDDLEAVFWRDAYFNGGLCVVVGLLVVGVAAFVVRSVTRPIDLIRQSMKRIADGDGAAEIQFAD
RGDEIGAIAKTLLVLRDSVNERSALQAREADQQRALEEARHGNEMVLRSASERQAHAMERLGHALEALANGDLTVELADI
GSDYEKLRVDFNRAVGALHGAIEAIARTGQVVNDSASDISGATGNLSRRTEQQAAALEETAAALDEITATVRTASERANE
ARQMVQDTKTSAGRSGEIVRNAVDAMGRIEDSSKRIGQIISVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVRE
LAQRSANAAKEIKTLINRSAEEVGGGVALVRSTGDALDEIVALVNRVDGHVNSIATAAREQATGLQEINTSVNHMDQMTQ
QNAAMVEETTAASQTLAEESQQLRALLSRFELGQGAGRAVSRAA

Sequences:

>Translated_604_residues
MKNVTISMRLYALVALFLAILAAALTFSLFESYREMERERKAGLAAMNETAVAIIKQYYQLEQGGSLTREAAQQQAKTTI
AAMRYGNGSGYFWINDMHPTMVMHPIKPEMNGTDLTANKDPNGKALFVEFVNTVKAGGQGFVDYYWPKPGAPDPVEKFSH
VAGFAPWGWIVGTGVYVDDLEAVFWRDAYFNGGLCVVVGLLVVGVAAFVVRSVTRPIDLIRQSMKRIADGDGAAEIQFAD
RGDEIGAIAKTLLVLRDSVNERSALQAREADQQRALEEARHGNEMVLRSASERQAHAMERLGHALEALANGDLTVELADI
GSDYEKLRVDFNRAVGALHGAIEAIARTGQVVNDSASDISGATGNLSRRTEQQAAALEETAAALDEITATVRTASERANE
ARQMVQDTKTSAGRSGEIVRNAVDAMGRIEDSSKRIGQIISVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVRE
LAQRSANAAKEIKTLINRSAEEVGGGVALVRSTGDALDEIVALVNRVDGHVNSIATAAREQATGLQEINTSVNHMDQMTQ
QNAAMVEETTAASQTLAEESQQLRALLSRFELGQGAGRAVSRAA
>Mature_604_residues
MKNVTISMRLYALVALFLAILAAALTFSLFESYREMERERKAGLAAMNETAVAIIKQYYQLEQGGSLTREAAQQQAKTTI
AAMRYGNGSGYFWINDMHPTMVMHPIKPEMNGTDLTANKDPNGKALFVEFVNTVKAGGQGFVDYYWPKPGAPDPVEKFSH
VAGFAPWGWIVGTGVYVDDLEAVFWRDAYFNGGLCVVVGLLVVGVAAFVVRSVTRPIDLIRQSMKRIADGDGAAEIQFAD
RGDEIGAIAKTLLVLRDSVNERSALQAREADQQRALEEARHGNEMVLRSASERQAHAMERLGHALEALANGDLTVELADI
GSDYEKLRVDFNRAVGALHGAIEAIARTGQVVNDSASDISGATGNLSRRTEQQAAALEETAAALDEITATVRTASERANE
ARQMVQDTKTSAGRSGEIVRNAVDAMGRIEDSSKRIGQIISVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVRE
LAQRSANAAKEIKTLINRSAEEVGGGVALVRSTGDALDEIVALVNRVDGHVNSIATAAREQATGLQEINTSVNHMDQMTQ
QNAAMVEETTAASQTLAEESQQLRALLSRFELGQGAGRAVSRAA

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=336, Percent_Identity=40.4761904761905, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI2367378, Length=273, Percent_Identity=45.4212454212454, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788195, Length=236, Percent_Identity=50.8474576271186, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788194, Length=293, Percent_Identity=41.9795221843003, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1789453, Length=243, Percent_Identity=39.0946502057613, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 64937; Mature: 64937

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVTISMRLYALVALFLAILAAALTFSLFESYREMERERKAGLAAMNETAVAIIKQYYQ
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LEQGGSLTREAAQQQAKTTIAAMRYGNGSGYFWINDMHPTMVMHPIKPEMNGTDLTANKD
HHCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCC
PNGKALFVEFVNTVKAGGQGFVDYYWPKPGAPDPVEKFSHVAGFAPWGWIVGTGVYVDDL
CCCCEEHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHCCCCHHHHH
EAVFWRDAYFNGGLCVVVGLLVVGVAAFVVRSVTRPIDLIRQSMKRIADGDGAAEIQFAD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
RGDEIGAIAKTLLVLRDSVNERSALQAREADQQRALEEARHGNEMVLRSASERQAHAMER
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHH
LGHALEALANGDLTVELADIGSDYEKLRVDFNRAVGALHGAIEAIARTGQVVNDSASDIS
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCC
GATGNLSRRTEQQAAALEETAAALDEITATVRTASERANEARQMVQDTKTSAGRSGEIVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
NAVDAMGRIEDSSKRIGQIISVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVRE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCCHHHHHHHHHH
LAQRSANAAKEIKTLINRSAEEVGGGVALVRSTGDALDEIVALVNRVDGHVNSIATAARE
HHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHH
QATGLQEINTSVNHMDQMTQQNAAMVEETTAASQTLAEESQQLRALLSRFELGQGAGRAV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SRAA
HCCC
>Mature Secondary Structure
MKNVTISMRLYALVALFLAILAAALTFSLFESYREMERERKAGLAAMNETAVAIIKQYYQ
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LEQGGSLTREAAQQQAKTTIAAMRYGNGSGYFWINDMHPTMVMHPIKPEMNGTDLTANKD
HHCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCC
PNGKALFVEFVNTVKAGGQGFVDYYWPKPGAPDPVEKFSHVAGFAPWGWIVGTGVYVDDL
CCCCEEHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHCCCCHHHHH
EAVFWRDAYFNGGLCVVVGLLVVGVAAFVVRSVTRPIDLIRQSMKRIADGDGAAEIQFAD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
RGDEIGAIAKTLLVLRDSVNERSALQAREADQQRALEEARHGNEMVLRSASERQAHAMER
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHH
LGHALEALANGDLTVELADIGSDYEKLRVDFNRAVGALHGAIEAIARTGQVVNDSASDIS
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCC
GATGNLSRRTEQQAAALEETAAALDEITATVRTASERANEARQMVQDTKTSAGRSGEIVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
NAVDAMGRIEDSSKRIGQIISVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVRE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCCHHHHHHHHHH
LAQRSANAAKEIKTLINRSAEEVGGGVALVRSTGDALDEIVALVNRVDGHVNSIATAARE
HHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHH
QATGLQEINTSVNHMDQMTQQNAAMVEETTAASQTLAEESQQLRALLSRFELGQGAGRAV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SRAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]