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The map label for this gene is cobT

Identifier: 159184968

GI number: 159184968

Start: 1869149

End: 1870183

Strand: Reverse

Name: cobT

Synonym: Atu1890

Alternate gene names: 159184968

Gene position: 1870183-1869149 (Counterclockwise)

Preceding gene: 17935786

Following gene: 159184967

Centisome position: 65.81

GC content: 65.02

Gene sequence:

>1035_bases
ATGAGCATGAGCGGATTGCCCTTCGACGATTTTCGCGCGCTGTTGCGTGAGCTTCCCGGCCCGGATACGCATGCGCTTGT
GGCGGCCAAGGAGCGCAACGCGCAGCTGACCAAGCCTGCGGGCTCGCTCGGCCGTCTGGAAGAGATCGCCATGTGGCTGG
CCGCGTGGTCCGGCCGTTCGCCCGCCGTCACCCGTCCGCTGGTGGCGATTTTCGCTGGCAATCACGGCGTCACCCGGCAT
GGCGTTACCCCTTATCCGACATCGGTTACCCAGCAGATGGTGGAGAATTTTGCCGCCGGCGGTGCTGCCATCAACCAGAT
TTGCGTTGCCAATGATCTCGGCCTGAAAATCTTCGATCTGGCGCTGGACTATCCGACCGGCGACATCACCTGCGAGCCGG
CGCTTTCGGAGCGTGACTGCGCCGCCACCATGGCCTTCGGCATGGAGGCGATTGCCGGTGGTACCGATCTTCTCTGCGTC
GGCGAAATGGGCATCGGCAATACCACGATTGCCGCCGCCATCAATCTGGCGCTCTACGGCGGCACGGCGGAAGAATGGAC
CGGTCCCGGCACCGGCTCGGAAGGCGAAGTCATGGCCCGCAAGATCGCGGCGGTGAAGGCTGCGGTGGAGTTCCACAAGG
ACCATCTGTCCGATCCGCTGGAAATCATGCGCCGCCTCGGCGGACGTGAGATTGCGGCGATTGCCGGCGCGATCCTCGCT
GCCCGCGTGCAGCGCATTCCCGTGCTGATCGACGGTTATGTGGCAACGGCCGCTGCCGCTCTGTTGAAGGCGGCCAATTC
TTCGGCGCTCGACCATTGCCTGATCGGCCACGTCTCGGGTGAACCTGGCCATCTCGCCGCCGTCGAGAAGCTTGGCAAGA
CGCCGCTTCTGGCGCTCGGCATGCGGCTTGGTGAAGGCACAGGTGCAGCGCTTGCCGCCGGCATCGTCAAGGCCGCTGCC
GCTTGCCATTCCGGCATGGCAACGTTCGAGGCGGCGGGTGTGGACACCCGCATCAGCCCGCGCACCGAGCATTGA

Upstream 100 bases:

>100_bases
ATTATGAGAGGCGCAACAAAGACCGATTTGCCGGAAAACACAAGTTCCGGACGCATGAGCCGATGCGACAGCCAACCCGG
CTACGAAAGAGACCGACACC

Downstream 100 bases:

>100_bases
GGTCAAAGATGGACGCGACGCCGCAGAAGCCGCAACCGGAACCCGCCTTTCGCAAGGAAAAAGGCTGGCGGCATCTTTTC
GCCGCCGCGCGTTATTCCGT

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSMSGLPFDDFRALLRELPGPDTHALVAAKERNAQLTKPAGSLGRLEEIAMWLAAWSGRSPAVTRPLVAIFAGNHGVTRH
GVTPYPTSVTQQMVENFAAGGAAINQICVANDLGLKIFDLALDYPTGDITCEPALSERDCAATMAFGMEAIAGGTDLLCV
GEMGIGNTTIAAAINLALYGGTAEEWTGPGTGSEGEVMARKIAAVKAAVEFHKDHLSDPLEIMRRLGGREIAAIAGAILA
ARVQRIPVLIDGYVATAAAALLKAANSSALDHCLIGHVSGEPGHLAAVEKLGKTPLLALGMRLGEGTGAALAAGIVKAAA
ACHSGMATFEAAGVDTRISPRTEH

Sequences:

>Translated_344_residues
MSMSGLPFDDFRALLRELPGPDTHALVAAKERNAQLTKPAGSLGRLEEIAMWLAAWSGRSPAVTRPLVAIFAGNHGVTRH
GVTPYPTSVTQQMVENFAAGGAAINQICVANDLGLKIFDLALDYPTGDITCEPALSERDCAATMAFGMEAIAGGTDLLCV
GEMGIGNTTIAAAINLALYGGTAEEWTGPGTGSEGEVMARKIAAVKAAVEFHKDHLSDPLEIMRRLGGREIAAIAGAILA
ARVQRIPVLIDGYVATAAAALLKAANSSALDHCLIGHVSGEPGHLAAVEKLGKTPLLALGMRLGEGTGAALAAGIVKAAA
ACHSGMATFEAAGVDTRISPRTEH
>Mature_343_residues
SMSGLPFDDFRALLRELPGPDTHALVAAKERNAQLTKPAGSLGRLEEIAMWLAAWSGRSPAVTRPLVAIFAGNHGVTRHG
VTPYPTSVTQQMVENFAAGGAAINQICVANDLGLKIFDLALDYPTGDITCEPALSERDCAATMAFGMEAIAGGTDLLCVG
EMGIGNTTIAAAINLALYGGTAEEWTGPGTGSEGEVMARKIAAVKAAVEFHKDHLSDPLEIMRRLGGREIAAIAGAILAA
RVQRIPVLIDGYVATAAAALLKAANSSALDHCLIGHVSGEPGHLAAVEKLGKTPLLALGMRLGEGTGAALAAGIVKAAAA
CHSGMATFEAAGVDTRISPRTEH

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=342, Percent_Identity=32.7485380116959, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_AGRT5 (Q8UE71)

Other databases:

- EMBL:   AE007869
- PIR:   AH2808
- PIR:   F97587
- RefSeq:   NP_354870.2
- ProteinModelPortal:   Q8UE71
- SMR:   Q8UE71
- STRING:   Q8UE71
- GeneID:   1133928
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1890
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   TVTELEL
- PhylomeDB:   Q8UE71
- ProtClustDB:   PRK00105
- BioCyc:   ATUM176299-1:ATU1890-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 35390; Mature: 35259

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: ACT_SITE 305-305

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSGLPFDDFRALLRELPGPDTHALVAAKERNAQLTKPAGSLGRLEEIAMWLAAWSGRS
CCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCC
PAVTRPLVAIFAGNHGVTRHGVTPYPTSVTQQMVENFAAGGAAINQICVANDLGLKIFDL
CCHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHEECCCCCEEEEE
ALDYPTGDITCEPALSERDCAATMAFGMEAIAGGTDLLCVGEMGIGNTTIAAAINLALYG
EEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHEEEC
GTAEEWTGPGTGSEGEVMARKIAAVKAAVEFHKDHLSDPLEIMRRLGGREIAAIAGAILA
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHH
ARVQRIPVLIDGYVATAAAALLKAANSSALDHCLIGHVSGEPGHLAAVEKLGKTPLLALG
HHHHHCCEEEECHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCHHHHHHHHCCCCHHHHH
MRLGEGTGAALAAGIVKAAAACHSGMATFEAAGVDTRISPRTEH
HHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SMSGLPFDDFRALLRELPGPDTHALVAAKERNAQLTKPAGSLGRLEEIAMWLAAWSGRS
CCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCC
PAVTRPLVAIFAGNHGVTRHGVTPYPTSVTQQMVENFAAGGAAINQICVANDLGLKIFDL
CCHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHEECCCCCEEEEE
ALDYPTGDITCEPALSERDCAATMAFGMEAIAGGTDLLCVGEMGIGNTTIAAAINLALYG
EEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHEEEC
GTAEEWTGPGTGSEGEVMARKIAAVKAAVEFHKDHLSDPLEIMRRLGGREIAAIAGAILA
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHH
ARVQRIPVLIDGYVATAAAALLKAANSSALDHCLIGHVSGEPGHLAAVEKLGKTPLLALG
HHHHHCCEEEECHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCHHHHHHHHCCCCHHHHH
MRLGEGTGAALAAGIVKAAAACHSGMATFEAAGVDTRISPRTEH
HHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194