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The map label for this gene is aqpZ

Identifier: 15887822

GI number: 15887822

Start: 464352

End: 465077

Strand: Direct

Name: aqpZ

Synonym: Atu0476

Alternate gene names: 15887822

Gene position: 464352-465077 (Clockwise)

Preceding gene: 159184327

Following gene: 15887823

Centisome position: 16.34

GC content: 59.23

Gene sequence:

>726_bases
ATGAGTCGCAAGTTTATCTCGGAATTTTTGGGTACTTTTTGGCTCGTGTTCGGAGGTTGCGGCAGTGCGGTTTTTGCCGC
CGCTTTTCCTGAACTCGGCATCGGCTTCCTTGGTGTTGCTTTCGCTTTTGGCTTGACGGTTCTGACCATGGCCTATGCGG
TTGGCGGCATTTCCGGCGGTCACTTCAATCCGGCGGTTTCCGTCGGCCTCACCGTTGCCGGCAAATTCCCGGCGGCGAAC
CTCGTGCCTTACATCGTGGCGCAGGTTCTGGGGGCGGTCGTCGCGGCTGCGGCGCTTTATGTTATTCTCACCGGCAAGGC
GGGTGCCGAAATCGGCGGTTTTGCCGCCAATGGTTATGGCGAGCATTCGCCGGGCGGATATTCTCTCCTGTCGGCGCTGC
TGATCGAGATCATCCTGACGGCGTTTTTCCTGGTTGTCATATTGGGGTCGACGCATGGCAGGGTGCCGGTCGGTTTCGCA
CCTGTCGCCATCGGTCTTGCACTCACCCTTATTCATCTGATTTCCATTCCGGTCACCAACACATCCGTCAATCCGGCCCG
CTCGACCGGGCAGGCCCTGTTCGTTGGCGGGTGGGCGCTGCAGCAGCTCTGGTTGTTCTGGCTTGCCCCAATTTTGGGCG
GTGCCATTGGCGCCGTGGTCTGGAAAATTTTCGGCGAGGAAGAAAAGGCTGGCCATGCCGGCTCGGTTCAACCCGCGAAG
ACGTGA

Upstream 100 bases:

>100_bases
CGTGATCAAGCCGCTCTCCGAGTGTATATGCAATTTAGCTTGACTACGATTAAATTGCACGTAATAGTTGATGCAGTCGT
AACATGAATGGGGAAGTGTT

Downstream 100 bases:

>100_bases
ATAAGAGGCTTTGTTTCCCCGAATGGTCGGGGAAACGACTGAGGAGGATGGCATGGATCTTACTTCGATATTGGCCCAGA
TTGTCGGCGGTGCGGTGGGC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSRKFISEFLGTFWLVFGGCGSAVFAAAFPELGIGFLGVAFAFGLTVLTMAYAVGGISGGHFNPAVSVGLTVAGKFPAAN
LVPYIVAQVLGAVVAAAALYVILTGKAGAEIGGFAANGYGEHSPGGYSLLSALLIEIILTAFFLVVILGSTHGRVPVGFA
PVAIGLALTLIHLISIPVTNTSVNPARSTGQALFVGGWALQQLWLFWLAPILGGAIGAVVWKIFGEEEKAGHAGSVQPAK
T

Sequences:

>Translated_241_residues
MSRKFISEFLGTFWLVFGGCGSAVFAAAFPELGIGFLGVAFAFGLTVLTMAYAVGGISGGHFNPAVSVGLTVAGKFPAAN
LVPYIVAQVLGAVVAAAALYVILTGKAGAEIGGFAANGYGEHSPGGYSLLSALLIEIILTAFFLVVILGSTHGRVPVGFA
PVAIGLALTLIHLISIPVTNTSVNPARSTGQALFVGGWALQQLWLFWLAPILGGAIGAVVWKIFGEEEKAGHAGSVQPAK
T
>Mature_240_residues
SRKFISEFLGTFWLVFGGCGSAVFAAAFPELGIGFLGVAFAFGLTVLTMAYAVGGISGGHFNPAVSVGLTVAGKFPAANL
VPYIVAQVLGAVVAAAALYVILTGKAGAEIGGFAANGYGEHSPGGYSLLSALLIEIILTAFFLVVILGSTHGRVPVGFAP
VAIGLALTLIHLISIPVTNTSVNPARSTGQALFVGGWALQQLWLFWLAPILGGAIGAVVWKIFGEEEKAGHAGSVQPAKT

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family

Homologues:

Organism=Homo sapiens, GI37694062, Length=226, Percent_Identity=34.9557522123894, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4502183, Length=218, Percent_Identity=36.697247706422, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI4502179, Length=224, Percent_Identity=35.2678571428571, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4755125, Length=213, Percent_Identity=32.3943661971831, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502181, Length=213, Percent_Identity=32.3943661971831, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912506, Length=222, Percent_Identity=34.2342342342342, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI86792455, Length=223, Percent_Identity=30.9417040358744, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI157266307, Length=236, Percent_Identity=31.7796610169492, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI22538420, Length=244, Percent_Identity=28.6885245901639, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45446752, Length=201, Percent_Identity=32.8358208955224, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4502187, Length=244, Percent_Identity=26.6393442622951, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4826645, Length=245, Percent_Identity=28.1632653061224, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=71.2918660287081, Blast_Score=287, Evalue=4e-79,
Organism=Escherichia coli, GI1790362, Length=242, Percent_Identity=29.7520661157025, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993722, Length=235, Percent_Identity=33.1914893617021, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71992966, Length=259, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17558372, Length=242, Percent_Identity=29.7520661157025, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994009, Length=241, Percent_Identity=28.2157676348548, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71992961, Length=257, Percent_Identity=26.8482490272374, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531429, Length=232, Percent_Identity=28.8793103448276, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531431, Length=232, Percent_Identity=28.8793103448276, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=201, Percent_Identity=30.3482587064677, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6325450, Length=228, Percent_Identity=27.6315789473684, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652747, Length=238, Percent_Identity=34.8739495798319, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI45551084, Length=238, Percent_Identity=34.8739495798319, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24652751, Length=222, Percent_Identity=35.1351351351351, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19922038, Length=222, Percent_Identity=35.1351351351351, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136672, Length=233, Percent_Identity=30.0429184549356, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550503, Length=228, Percent_Identity=27.1929824561404, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24762344, Length=226, Percent_Identity=30.9734513274336, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762346, Length=226, Percent_Identity=30.9734513274336, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762348, Length=226, Percent_Identity=30.9734513274336, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130305, Length=226, Percent_Identity=30.9734513274336, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762342, Length=232, Percent_Identity=26.2931034482759, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AQPZ1_AGRT5 (Q8UI24)

Other databases:

- EMBL:   AE007869
- PIR:   AI2634
- PIR:   G97416
- RefSeq:   NP_353503.1
- ProteinModelPortal:   Q8UI24
- SMR:   Q8UI24
- STRING:   Q8UI24
- GeneID:   1132514
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0476
- eggNOG:   COG0580
- HOGENOM:   HBG705794
- OMA:   LYLIELV
- PhylomeDB:   Q8UI24
- ProtClustDB:   PRK05420
- BioCyc:   ATUM176299-1:ATU0476-MONOMER
- HAMAP:   MF_01146
- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357
- PANTHER:   PTHR19139
- PRINTS:   PR00783
- TIGRFAMs:   TIGR00861

Pfam domain/function: PF00230 MIP

EC number: NA

Molecular weight: Translated: 24544; Mature: 24413

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00221 MIP; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc4c77d4)-; HASH(0xbf44d4c)-; HASH(0xc1e6a9c)-; HASH(0xccd79b4)-; HASH(0xcfaf7f4)-; HASH(0xccfd7c0)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKFISEFLGTFWLVFGGCGSAVFAAAFPELGIGFLGVAFAFGLTVLTMAYAVGGISGG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSVGLTVAGKFPAANLVPYIVAQVLGAVVAAAALYVILTGKAGAEIGGFAANGYG
CCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCC
EHSPGGYSLLSALLIEIILTAFFLVVILGSTHGRVPVGFAPVAIGLALTLIHLISIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGQALFVGGWALQQLWLFWLAPILGGAIGAVVWKIFGEEEKAGHAGSVQPAK
CCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
T
H
>Mature Secondary Structure 
SRKFISEFLGTFWLVFGGCGSAVFAAAFPELGIGFLGVAFAFGLTVLTMAYAVGGISGG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSVGLTVAGKFPAANLVPYIVAQVLGAVVAAAALYVILTGKAGAEIGGFAANGYG
CCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCC
EHSPGGYSLLSALLIEIILTAFFLVVILGSTHGRVPVGFAPVAIGLALTLIHLISIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGQALFVGGWALQQLWLFWLAPILGGAIGAVVWKIFGEEEKAGHAGSVQPAK
CCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
T
H

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194