Click here to switch to the map view.

The map label for this gene is tdk

Identifier: 57652141

GI number: 57652141

Start: 2170932

End: 2171531

Strand: Reverse

Name: tdk

Synonym: SACOL2111

Alternate gene names: 57652141

Gene position: 2171531-2170932 (Counterclockwise)

Preceding gene: 57652142

Following gene: 57652140

Centisome position: 77.29

GC content: 37.0

Gene sequence:

>600_bases
ATGTATGAAACTTACCATTCCGGTTGGATAGAATGTATTACAGGTAGTATGTTTAGCGGTAAATCCGAAGAACTAATAAG
ACGTCTAAGAAGGGGTATATACGCTAAACAAAAAGTCGTTGTATTTAAACCGGCGATTGATGATCGATATCATAAAGAAA
AAGTGGTCTCTCATAATGGTAATGCCATTGAAGCGATTAATATTTCTAAAGCAAGTGAAATTATGACGCACGACTTAACT
AATGTTGATGTTATAGGAATAGACGAAGTGCAATTTTTTGACGATGAAATTGTAAGTATAGTAGAAAAACTATCAGCAGA
TGGACACCGTGTTATTGTTGCTGGATTAGATATGGATTTTAGGGGCGAACCGTTCGAACCAATGCCTAAATTGATGGCTG
TCAGTGAACAAGTAACGAAACTTCAAGCAGTTTGTGCTGTTTGTGGTTCTTCATCTAGTAGAACGCAACGATTAATAAAT
GGTAAACCAGCTAAAATCGATGATCCGATTATCTTAGTAGGTGCCAATGAAAGTTATGAGCCACGTTGTCGCGCGCACCA
TATCGTAGCACCTAGTGATAATAATAAGGAGGAATTATAA

Upstream 100 bases:

>100_bases
GTTCATGTACAATATCGATATAATTATGAAAAAGACATTTATGAATATTTGAAATATGATATAATAAAGCGATTATGTTT
TGAAAAAGGTGGAACTCTCA

Downstream 100 bases:

>100_bases
GTGTTTGATCAATTAGATATTGTAGAAGAAAGATACGAACAGTTAAATGAACTGTTAAGTGACCCAGATGTTGTAAATGA
TTCAGATAAATTACGTAAAT

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MYETYHSGWIECITGSMFSGKSEELIRRLRRGIYAKQKVVVFKPAIDDRYHKEKVVSHNGNAIEAINISKASEIMTHDLT
NVDVIGIDEVQFFDDEIVSIVEKLSADGHRVIVAGLDMDFRGEPFEPMPKLMAVSEQVTKLQAVCAVCGSSSSRTQRLIN
GKPAKIDDPIILVGANESYEPRCRAHHIVAPSDNNKEEL

Sequences:

>Translated_199_residues
MYETYHSGWIECITGSMFSGKSEELIRRLRRGIYAKQKVVVFKPAIDDRYHKEKVVSHNGNAIEAINISKASEIMTHDLT
NVDVIGIDEVQFFDDEIVSIVEKLSADGHRVIVAGLDMDFRGEPFEPMPKLMAVSEQVTKLQAVCAVCGSSSSRTQRLIN
GKPAKIDDPIILVGANESYEPRCRAHHIVAPSDNNKEEL
>Mature_199_residues
MYETYHSGWIECITGSMFSGKSEELIRRLRRGIYAKQKVVVFKPAIDDRYHKEKVVSHNGNAIEAINISKASEIMTHDLT
NVDVIGIDEVQFFDDEIVSIVEKLSADGHRVIVAGLDMDFRGEPFEPMPKLMAVSEQVTKLQAVCAVCGSSSSRTQRLIN
GKPAKIDDPIILVGANESYEPRCRAHHIVAPSDNNKEEL

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Homo sapiens, GI164698438, Length=181, Percent_Identity=38.6740331491713, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1787490, Length=182, Percent_Identity=29.1208791208791, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17543396, Length=196, Percent_Identity=31.6326530612245, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_STAA3 (Q2FF09)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494719.1
- ProteinModelPortal:   Q2FF09
- SMR:   Q2FF09
- STRING:   Q2FF09
- EnsemblBacteria:   EBSTAT00000038069
- GeneID:   3913975
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_2073
- eggNOG:   COG1435
- GeneTree:   EBGT00050000023861
- HOGENOM:   HBG522108
- OMA:   NEIRSTP
- ProtClustDB:   PRK04296
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 22215; Mature: 22215

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00603 TK_CELLULAR_TYPE; PS00014 ER_TARGET

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYETYHSGWIECITGSMFSGKSEELIRRLRRGIYAKQKVVVFKPAIDDRYHKEKVVSHNG
CCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCC
NAIEAINISKASEIMTHDLTNVDVIGIDEVQFFDDEIVSIVEKLSADGHRVIVAGLDMDF
CEEEEEECCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
RGEPFEPMPKLMAVSEQVTKLQAVCAVCGSSSSRTQRLINGKPAKIDDPIILVGANESYE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCC
PRCRAHHIVAPSDNNKEEL
CCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MYETYHSGWIECITGSMFSGKSEELIRRLRRGIYAKQKVVVFKPAIDDRYHKEKVVSHNG
CCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCC
NAIEAINISKASEIMTHDLTNVDVIGIDEVQFFDDEIVSIVEKLSADGHRVIVAGLDMDF
CEEEEEECCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
RGEPFEPMPKLMAVSEQVTKLQAVCAVCGSSSSRTQRLINGKPAKIDDPIILVGANESYE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCC
PRCRAHHIVAPSDNNKEEL
CCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA