| Definition | Staphylococcus aureus subsp. aureus COL chromosome, complete genome. |
|---|---|
| Accession | NC_002951 |
| Length | 2,809,422 |
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The map label for this gene is yvgN [H]
Identifier: 57652081
GI number: 57652081
Start: 1889489
End: 1890322
Strand: Reverse
Name: yvgN [H]
Synonym: SACOL1835
Alternate gene names: 57652081
Gene position: 1890322-1889489 (Counterclockwise)
Preceding gene: 57652082
Following gene: 57652078
Centisome position: 67.29
GC content: 34.53
Gene sequence:
>834_bases ATGGAGGTTAAAACATTTTATAATGGAAACACGATGCCACAAATTGGTTTAGGGACATTTCGTGTGGAAAATGATGAAAA TTGCATGGAAAGTGTTAAGTATGCCATTGAACAAGGATATCGTAGTATTGATACCGCAAAAGTTTATGGGAATGAAGAAC AAGTAGGTGCTGGCATTCGTGCCGGATTGGAGTCAACTGGTATTGCTAGAGAAGACTTATTTATTACTTCAAAATTATAT TTTGAGGATTTCGGTCGTGAAAATGTAGCAGCTGCTTACGAAGCTAGTTTATCTAGATTAGGTTTAAAATACTTAGATTT GTATCTAGTACATTGGCCAGGTACGAACGAAGCCGTAATGGTTGATACATGGAAAGGTATGGAAGATTTATATAAAAATA ATAATGTTAAAAATATAGGTGTCAGCAATTTTGAACCTGAACATTTGGAAGCTTTGTTGGCACAAGTGTCAATTAAACCT GTAATTAATCAAGTTGAATATCATCCATATTTAACCCAACATAAATTGAAATTATATTTGGCAGCACAACGTATCGTGAT GGAATCTTGGTCACCATTGATGAATGCACAAATTTTAAATGATGAGACAATTAAAGACATTGCTCAAGAATTAGGAAAGT CACCTGCCCAAGTTGTTTTAAGATGGAATGTGCAGCATGCTGTGGTTACAATCCCTAAATCGGTGACACCAAACAGAATC TCTGAAAATTTCCAAATATTTGATTTCGAATTATCAGATGAACAAATGACGCGAATTGATGGTTTAAATCAAGATAAGAG AATTGGACCTGATCCAAAAAAATTTGAAGGCTAG
Upstream 100 bases:
>100_bases ATTTTAGTGGTTGATTGCTCTAAGTGTTTTTTCTCATGTATTCAACTCAGATTTGTTATGATAACAGGGTATAATACATC AAAAAGGTGAGGCGATATTT
Downstream 100 bases:
>100_bases ATTAAAATCGCTCAACTGATGAAAAGGTTAGATGAATTGTCAGGGCTTGGGACATTAAGTTCTTAGGCGATGTAAAAAAG CTGATTTCTATTAATTATTT
Product: aldo/keto reductase family oxidoreductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 277; Mature: 277
Protein sequence:
>277_residues MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKP VINQVEYHPYLTQHKLKLYLAAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG
Sequences:
>Translated_277_residues MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKP VINQVEYHPYLTQHKLKLYLAAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG >Mature_277_residues MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKP VINQVEYHPYLTQHKLKLYLAAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI223468663, Length=286, Percent_Identity=42.3076923076923, Blast_Score=212, Evalue=4e-55, Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=38.4868421052632, Blast_Score=204, Evalue=1e-52, Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=36.426116838488, Blast_Score=202, Evalue=3e-52, Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=36.426116838488, Blast_Score=202, Evalue=3e-52, Organism=Homo sapiens, GI291291012, Length=268, Percent_Identity=40.2985074626866, Blast_Score=191, Evalue=6e-49, Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=37.2881355932203, Blast_Score=186, Evalue=3e-47, Organism=Homo sapiens, GI45446745, Length=293, Percent_Identity=37.2013651877133, Blast_Score=184, Evalue=6e-47, Organism=Homo sapiens, GI4503285, Length=293, Percent_Identity=37.2013651877133, Blast_Score=184, Evalue=6e-47, Organism=Homo sapiens, GI4502049, Length=291, Percent_Identity=40.893470790378, Blast_Score=184, Evalue=7e-47, Organism=Homo sapiens, GI310109920, Length=293, Percent_Identity=36.8600682593857, Blast_Score=184, Evalue=8e-47, Organism=Homo sapiens, GI5453543, Length=293, Percent_Identity=36.518771331058, Blast_Score=184, Evalue=9e-47, Organism=Homo sapiens, GI24497585, Length=293, Percent_Identity=37.542662116041, Blast_Score=182, Evalue=3e-46, Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=38.1818181818182, Blast_Score=182, Evalue=4e-46, Organism=Homo sapiens, GI24497583, Length=291, Percent_Identity=36.0824742268041, Blast_Score=174, Evalue=1e-43, Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=36.2637362637363, Blast_Score=163, Evalue=2e-40, Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=35.5072463768116, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI207028673, Length=121, Percent_Identity=43.801652892562, Blast_Score=99, Evalue=3e-21, Organism=Homo sapiens, GI310109926, Length=121, Percent_Identity=42.9752066115703, Blast_Score=99, Evalue=5e-21, Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=36.3636363636364, Blast_Score=98, Evalue=7e-21, Organism=Escherichia coli, GI87082198, Length=277, Percent_Identity=44.4043321299639, Blast_Score=246, Evalue=1e-66, Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=32.6923076923077, Blast_Score=148, Evalue=4e-37, Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=30.2816901408451, Blast_Score=110, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17537077, Length=290, Percent_Identity=36.8965517241379, Blast_Score=186, Evalue=9e-48, Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=39.3258426966292, Blast_Score=184, Evalue=4e-47, Organism=Caenorhabditis elegans, GI17564128, Length=294, Percent_Identity=33.6734693877551, Blast_Score=182, Evalue=1e-46, Organism=Caenorhabditis elegans, GI17538386, Length=269, Percent_Identity=36.0594795539033, Blast_Score=180, Evalue=7e-46, Organism=Caenorhabditis elegans, GI17537075, Length=296, Percent_Identity=36.1486486486487, Blast_Score=179, Evalue=1e-45, Organism=Caenorhabditis elegans, GI17552492, Length=279, Percent_Identity=32.258064516129, Blast_Score=171, Evalue=5e-43, Organism=Caenorhabditis elegans, GI17550248, Length=289, Percent_Identity=33.5640138408304, Blast_Score=160, Evalue=1e-39, Organism=Caenorhabditis elegans, GI17561298, Length=269, Percent_Identity=33.457249070632, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=34.1911764705882, Blast_Score=157, Evalue=4e-39, Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=32.4232081911263, Blast_Score=153, Evalue=8e-38, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=31.8840579710145, Blast_Score=153, Evalue=1e-37, Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=29.8657718120805, Blast_Score=149, Evalue=2e-36, Organism=Caenorhabditis elegans, GI17550246, Length=75, Percent_Identity=44, Blast_Score=68, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6324694, Length=296, Percent_Identity=37.1621621621622, Blast_Score=176, Evalue=5e-45, Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=35.7142857142857, Blast_Score=174, Evalue=1e-44, Organism=Saccharomyces cerevisiae, GI6320576, Length=291, Percent_Identity=35.7388316151203, Blast_Score=173, Evalue=2e-44, Organism=Saccharomyces cerevisiae, GI6321896, Length=312, Percent_Identity=31.7307692307692, Blast_Score=156, Evalue=4e-39, Organism=Saccharomyces cerevisiae, GI6319625, Length=272, Percent_Identity=33.4558823529412, Blast_Score=142, Evalue=7e-35, Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=32.5088339222615, Blast_Score=138, Evalue=9e-34, Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=39.4463667820069, Blast_Score=196, Evalue=2e-50, Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=38.6206896551724, Blast_Score=188, Evalue=4e-48, Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=38.2758620689655, Blast_Score=187, Evalue=5e-48, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=37.3333333333333, Blast_Score=184, Evalue=6e-47, Organism=Drosophila melanogaster, GI24662789, Length=292, Percent_Identity=36.986301369863, Blast_Score=184, Evalue=7e-47, Organism=Drosophila melanogaster, GI24662785, Length=292, Percent_Identity=43.8356164383562, Blast_Score=182, Evalue=2e-46, Organism=Drosophila melanogaster, GI20129731, Length=285, Percent_Identity=37.1929824561403, Blast_Score=180, Evalue=8e-46, Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=43.5374149659864, Blast_Score=180, Evalue=1e-45, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=35, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI45553081, Length=287, Percent_Identity=33.1010452961672, Blast_Score=155, Evalue=2e-38, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=32.421875, Blast_Score=133, Evalue=1e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31472; Mature: 31472
Theoretical pI: Translated: 4.77; Mature: 4.77
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIR CCEEEEECCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCCCCCHHEECCCHHHHCCHHH AGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVM CCCHHCCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEE VDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYL EECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH AAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI HHHHHHHHHCCHHHCEEECCCHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHH SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG CCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIR CCEEEEECCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCCCCCHHEECCCHHHHCCHHH AGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVM CCCHHCCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEE VDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYL EECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH AAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI HHHHHHHHHCCHHHCEEECCCHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHH SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG CCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]