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The map label for this gene is gluP [H]

Identifier: 57651942

GI number: 57651942

Start: 1636419

End: 1637882

Strand: Reverse

Name: gluP [H]

Synonym: SACOL1606

Alternate gene names: 57651942

Gene position: 1637882-1636419 (Counterclockwise)

Preceding gene: 57651943

Following gene: 57651941

Centisome position: 58.3

GC content: 27.66

Gene sequence:

>1464_bases
ATGAACATAGACAAACAATTTTGGAAAACAATATATTATTGGATTAGGTACTTGAATTTTGATATTGTCAGTAGGGAAAA
AGATGACCAAGAAATTTGGTTAGCCCATAAAAGAAAAAAACAAGTAGTCATTTTTAAACAACATATCAAGTCTACCCAAG
AAATACGTTTTGACAAAGCGAAAGTGCTTGAACACAAAGATGAAATAGCAAATTTTATTTCTTTCGAACCACAAAGTTTT
GAATTTTATTATTTTACAGAATCGGAATTTTCAGAAGAACAATTAAATGAAGTTTCGCCAATTAGAATTAAATTCAATGT
TATAAGACACACAAAAGATTTGATAAAGCATATGCCGAATATATTTTTGGCTAGACTTATTTCAGAAGATAATGATAAAA
AGACATATATGTTCTATAAACGCAAAGTATTAACCGATAACTTTTTAGATAAATATATGCAGAAATTTTCACCGGCAACA
TACACAATAATATTTGTAAATGTCTTAATATGGTTATGTATGATTTTATATTTAAATAATTTTTCGGATGTAAAATTATT
AGATGTTGGCGGGTTAGTGCATTTTAATGTCGTACATGGTGAATGGTATCGAATTGTTACATCGATGTTTTTACATTTTA
GTTTTGAACATATACTTATGAATATGCTTTCATTATTTATTTTTGGTAAAATAGTCGAAGCAATTATTGGTTCATGGCGG
ATGTTAACTGTATACTTTATTGCAGGGTTGTTTGGAAACTTTGTATCACTATCATTTAATACGACTACAATTTCAGTTGG
GGCTAGTGGTGCTATATTTGGTCTGATTGGATCAATTTTTGCGATGATGTATGTTTCAAAAACATTTAACAAAAAAATGT
TAGGACAGTTATTAATTGCATTAGTGATATTAGTTGGTGTTTCTCTGTTTATGTCAAATATAAATATTGTGGCGCATATT
GGAGGATTCATTGGTGGTTTATTAATAACTTTAATTGGCTATTACTATAAAGTGAATCGTAATATTTTTTGGATTTTACT
AATTGGTATGCTTGTTATATTTATTGCACTTCAAATTAGAATTTTTACAATTAAAGAAGATAATATTTATAATAAATTGA
TCAAAGATGATATGACTAGTGGTAATTATGATAATGCTCAAAATATTGTGAAGCAGACAATAAATAAAAATTATGCCGAT
GATCAAACATATTATTTAAGTGGTATGATTATGGCTACTATCAATTCTAAGTCCGAAGGTATGACAGAATGGGAGCGAGG
ACTTAGAATGTTTCCTAAATCAGGTTTATTAAATTTTGAGTTAGCGATAGCAAATCGTTCATTAAATGATGATGAAAAAG
CATTAAAATATGTGCGTAAAGCATTAAATGCAGACCCTAAAAATACAGATTATATTAACTTAGAAAAAGAGTTGACTAAA
TCAAATGAGTCGAAAAATAAATAA

Upstream 100 bases:

>100_bases
GCTTATTATACGATTTTCAAATAACATCATTTGAACCGGAATCATTCGATCAACCAGTCGATAAATTGATTATATATCAA
GCAGCATAGTGGAGGACTAA

Downstream 100 bases:

>100_bases
CTTTTATGATGTACAACAGTTATTGAAAAGTTACGGATTTCTAATATATTTTAAAAATCCAGAAGATATGTACGAAATGA
TTCAACAGGAGATTTCATCA

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MNIDKQFWKTIYYWIRYLNFDIVSREKDDQEIWLAHKRKKQVVIFKQHIKSTQEIRFDKAKVLEHKDEIANFISFEPQSF
EFYYFTESEFSEEQLNEVSPIRIKFNVIRHTKDLIKHMPNIFLARLISEDNDKKTYMFYKRKVLTDNFLDKYMQKFSPAT
YTIIFVNVLIWLCMILYLNNFSDVKLLDVGGLVHFNVVHGEWYRIVTSMFLHFSFEHILMNMLSLFIFGKIVEAIIGSWR
MLTVYFIAGLFGNFVSLSFNTTTISVGASGAIFGLIGSIFAMMYVSKTFNKKMLGQLLIALVILVGVSLFMSNINIVAHI
GGFIGGLLITLIGYYYKVNRNIFWILLIGMLVIFIALQIRIFTIKEDNIYNKLIKDDMTSGNYDNAQNIVKQTINKNYAD
DQTYYLSGMIMATINSKSEGMTEWERGLRMFPKSGLLNFELAIANRSLNDDEKALKYVRKALNADPKNTDYINLEKELTK
SNESKNK

Sequences:

>Translated_487_residues
MNIDKQFWKTIYYWIRYLNFDIVSREKDDQEIWLAHKRKKQVVIFKQHIKSTQEIRFDKAKVLEHKDEIANFISFEPQSF
EFYYFTESEFSEEQLNEVSPIRIKFNVIRHTKDLIKHMPNIFLARLISEDNDKKTYMFYKRKVLTDNFLDKYMQKFSPAT
YTIIFVNVLIWLCMILYLNNFSDVKLLDVGGLVHFNVVHGEWYRIVTSMFLHFSFEHILMNMLSLFIFGKIVEAIIGSWR
MLTVYFIAGLFGNFVSLSFNTTTISVGASGAIFGLIGSIFAMMYVSKTFNKKMLGQLLIALVILVGVSLFMSNINIVAHI
GGFIGGLLITLIGYYYKVNRNIFWILLIGMLVIFIALQIRIFTIKEDNIYNKLIKDDMTSGNYDNAQNIVKQTINKNYAD
DQTYYLSGMIMATINSKSEGMTEWERGLRMFPKSGLLNFELAIANRSLNDDEKALKYVRKALNADPKNTDYINLEKELTK
SNESKNK
>Mature_487_residues
MNIDKQFWKTIYYWIRYLNFDIVSREKDDQEIWLAHKRKKQVVIFKQHIKSTQEIRFDKAKVLEHKDEIANFISFEPQSF
EFYYFTESEFSEEQLNEVSPIRIKFNVIRHTKDLIKHMPNIFLARLISEDNDKKTYMFYKRKVLTDNFLDKYMQKFSPAT
YTIIFVNVLIWLCMILYLNNFSDVKLLDVGGLVHFNVVHGEWYRIVTSMFLHFSFEHILMNMLSLFIFGKIVEAIIGSWR
MLTVYFIAGLFGNFVSLSFNTTTISVGASGAIFGLIGSIFAMMYVSKTFNKKMLGQLLIALVILVGVSLFMSNINIVAHI
GGFIGGLLITLIGYYYKVNRNIFWILLIGMLVIFIALQIRIFTIKEDNIYNKLIKDDMTSGNYDNAQNIVKQTINKNYAD
DQTYYLSGMIMATINSKSEGMTEWERGLRMFPKSGLLNFELAIANRSLNDDEKALKYVRKALNADPKNTDYINLEKELTK
SNESKNK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI115532986, Length=141, Percent_Identity=30.4964539007092, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI133901888, Length=141, Percent_Identity=30.4964539007092, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45552313, Length=203, Percent_Identity=25.615763546798, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 56890; Mature: 56890

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50005 TPR L=RR ; PS50293 TPR_REGION ; PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDKQFWKTIYYWIRYLNFDIVSREKDDQEIWLAHKRKKQVVIFKQHIKSTQEIRFDKA
CCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHH
KVLEHKDEIANFISFEPQSFEFYYFTESEFSEEQLNEVSPIRIKFNVIRHTKDLIKHMPN
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
IFLARLISEDNDKKTYMFYKRKVLTDNFLDKYMQKFSPATYTIIFVNVLIWLCMILYLNN
HHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
FSDVKLLDVGGLVHFNVVHGEWYRIVTSMFLHFSFEHILMNMLSLFIFGKIVEAIIGSWR
CCCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
MLTVYFIAGLFGNFVSLSFNTTTISVGASGAIFGLIGSIFAMMYVSKTFNKKMLGQLLIA
HHHHHHHHHHHHHHEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVILVGVSLFMSNINIVAHIGGFIGGLLITLIGYYYKVNRNIFWILLIGMLVIFIALQIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHE
IFTIKEDNIYNKLIKDDMTSGNYDNAQNIVKQTINKNYADDQTYYLSGMIMATINSKSEG
EEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCC
MTEWERGLRMFPKSGLLNFELAIANRSLNDDEKALKYVRKALNADPKNTDYINLEKELTK
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHC
SNESKNK
CCCCCCC
>Mature Secondary Structure
MNIDKQFWKTIYYWIRYLNFDIVSREKDDQEIWLAHKRKKQVVIFKQHIKSTQEIRFDKA
CCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHH
KVLEHKDEIANFISFEPQSFEFYYFTESEFSEEQLNEVSPIRIKFNVIRHTKDLIKHMPN
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
IFLARLISEDNDKKTYMFYKRKVLTDNFLDKYMQKFSPATYTIIFVNVLIWLCMILYLNN
HHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
FSDVKLLDVGGLVHFNVVHGEWYRIVTSMFLHFSFEHILMNMLSLFIFGKIVEAIIGSWR
CCCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
MLTVYFIAGLFGNFVSLSFNTTTISVGASGAIFGLIGSIFAMMYVSKTFNKKMLGQLLIA
HHHHHHHHHHHHHHEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVILVGVSLFMSNINIVAHIGGFIGGLLITLIGYYYKVNRNIFWILLIGMLVIFIALQIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHE
IFTIKEDNIYNKLIKDDMTSGNYDNAQNIVKQTINKNYADDQTYYLSGMIMATINSKSEG
EEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCC
MTEWERGLRMFPKSGLLNFELAIANRSLNDDEKALKYVRKALNADPKNTDYINLEKELTK
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHC
SNESKNK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]