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The map label for this gene is gcvT

Identifier: 57651931

GI number: 57651931

Start: 1628778

End: 1629869

Strand: Reverse

Name: gcvT

Synonym: SACOL1595

Alternate gene names: 57651931

Gene position: 1629869-1628778 (Counterclockwise)

Preceding gene: 57651932

Following gene: 57651930

Centisome position: 58.01

GC content: 31.32

Gene sequence:

>1092_bases
ATGTCAAGTGATTTAAAACAAACACCTTTATATCAAAATTATGTTGATAGAGGTGCAAAAATTGTGGAATTCGGAGGATG
GGCGATGCCTGTTCAATTTTCAAGTATTAAAGAGGAGCATAATGCTGTTCGATACGAAATTGGCCTGTTTGATGTTAGTC
ATATGGGTGAAATTGAAGTAACAGGTAAAGATGCTAGTCAGTTTGTGCAATATTTATTATCAAATGATACTGATAATTTA
ACTACTTCAAAAGCATTATATACTGCTTTATGTAATGAAGAAGGCGGTATTATTGATGATTTAGTAATATATAAATTAGC
TGACGACAATTATTTATTAGTTGTTAATGCTGCTAATACTGAAAAAGATTTTAATTGGATTTTAAAACACAAAGAGAAAT
TTGATGTTGAAGTACAAAATGTATCAAACCAATATGGTCAATTAGCAATACAAGGACCAAAAGCTAGAGATTTAATTAAT
CAATTAGTTGATGAAGATGTAACTGAAATGAAAATGTTTGAATTTAAACAGGGTGTCAAATTATTTGGAGCAAACGTCAT
TTTATCTCAGTCAGGTTACACAGGTGAAGATGGGTTTGAAATTTATTGTAATATCGATGATACTGAAAAAATTTGGGATG
GTTTATTAGAGTATAATGTTATGCCATGTGGGTTAGGCGCTCGTGATACATTAAGATTAGAGGCTGGATTGCCATTACAT
GGACAAGATTTAACTGAATCAATTACACCATATGAAGGTGGTATCGCTTTTGCAAGTAAACCATTAATTGATGCTGATTT
TATTGGTAAATCTGTATTAAAAGATCAAAAAGAAAATGGTGCACCAAGAAGAACAGTGGGATTAGAATTACTTGAAAAAG
GAATTGCAAGAACTGGTTATGAAGTTATGGATTTAGATGGAAATATTATTGGAGAAGTAACTTCAGGAACACAGTCTCCA
TCATCAGGAAAATCAATTGCACTTGCAATGATAAAAAGAGATGAGTTTGAAATGGGTAGAGAGTTGCTTGTTCAAGTTCG
TAAGCGTCAATTAAAAGCGAAAATTGTTAAGAAAAATCAAATTGATAAATAA

Upstream 100 bases:

>100_bases
TCAGGCAAAAGGATAATACTGTAACGCGTTCCTGAATTGGTGATTTATAAACAGGGTAGCGATTGCTATCCTGTTTTTAT
AATTTTAAGGGGGTATTTCA

Downstream 100 bases:

>100_bases
TTAAAAAGGGGTGTGCATTGTGAGTCATCGTTATATACCTTTAACTGAAAAAGACAAGCAAGAAATGTTACAAACAATTG
GTGCAAAATCTATAGGAGAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNL
TTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLIN
QLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLH
GQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSP
SSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK

Sequences:

>Translated_363_residues
MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNL
TTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLIN
QLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLH
GQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSP
SSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
>Mature_362_residues
SSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLT
TSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQ
LVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHG
QDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPS
SGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=365, Percent_Identity=33.6986301369863, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI257796258, Length=354, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI257796254, Length=358, Percent_Identity=30.4469273743017, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=31.629392971246, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI24797151, Length=334, Percent_Identity=26.9461077844311, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI197927446, Length=367, Percent_Identity=23.7057220708447, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI21361378, Length=367, Percent_Identity=23.7057220708447, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI194306651, Length=376, Percent_Identity=24.2021276595745, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1789272, Length=362, Percent_Identity=42.8176795580111, Blast_Score=273, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17560118, Length=367, Percent_Identity=36.7847411444142, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32563613, Length=381, Percent_Identity=25.1968503937008, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=346, Percent_Identity=25.7225433526012, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994045, Length=347, Percent_Identity=26.2247838616715, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=35.0649350649351, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20129441, Length=367, Percent_Identity=33.7874659400545, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI28571104, Length=357, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI20130091, Length=331, Percent_Identity=22.9607250755287, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_STAA1 (A7X2S3)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442114.1
- ProteinModelPortal:   A7X2S3
- SMR:   A7X2S3
- STRING:   A7X2S3
- EnsemblBacteria:   EBSTAT00000005243
- GeneID:   5560853
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1524
- eggNOG:   COG0404
- GeneTree:   EBGT00050000024988
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- BioCyc:   SAUR418127:SAHV_1524-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40458; Mature: 40327

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEV
CCCCCCCCCCHHHHHHCCCEEEEECCEEEEEEHHHHHHHCCEEEEEEEEEEECCCCEEEE
TGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANT
ECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCEEEEEECCCC
EKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVK
CCHHHHHHHCCHHCCEEHHHHCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCHH
LFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLH
HCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCC
GQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGY
CCCHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
EVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQ
EEEECCCCEEEEECCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
IDK
CCC
>Mature Secondary Structure 
SSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEV
CCCCCCCCCHHHHHHCCCEEEEECCEEEEEEHHHHHHHCCEEEEEEEEEEECCCCEEEE
TGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANT
ECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCEEEEEECCCC
EKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVK
CCHHHHHHHCCHHCCEEHHHHCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCHH
LFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLH
HCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCC
GQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGY
CCCHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
EVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQ
EEEECCCCEEEEECCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
IDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA