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The map label for this gene is argH

Identifier: 57651651

GI number: 57651651

Start: 965546

End: 966925

Strand: Reverse

Name: argH

Synonym: SACOL0963

Alternate gene names: 57651651

Gene position: 966925-965546 (Counterclockwise)

Preceding gene: 57651652

Following gene: 57651650

Centisome position: 34.42

GC content: 34.57

Gene sequence:

>1380_bases
ATGAGCAATAAAGCTTGGGGCGGTAGATTTGAAGTACAACCTGAAGAGTGGGTTGACGACTTTAACGCATCCATTACTTT
TGATCAAACGCTCATAGATCAAGATATCGAAGGCAGCATTGCACATGCAACTATGCTTGCGAATCAAGGCATTATTAGTC
AACAAGACAGCGAACAAATTATACAAGGACTAAAATCTATTCAACATGATTATCATCAAGATCAAATTCAATTTAGTGCA
TCATTAGAAGATATTCATTTAAATATTGAACATGAATTAATTAAACGTATCGGTGATGCTGGTGGTAAGTTGCATACTGG
ACGCAGTAGAAACGATCAAGTTGCAACAGACATGCACTTGTACACTAAGAAACAAGTGCAAGATATCATCGCATTAATTA
AGTCGTTACAAAGTGTAATTGTAGACATCGCTTCCAATAATGTTGATACAATTATGCCTGGTTATACTCATTTACAGCGT
GCACAGCCAATTTCATTTGCACATCATATTATGACTTATTTTTGGATGTTACAACGAGACCAACAACGATTTGAAGATAG
TTTAAAACGAATCGATATTAATCCTTTAGGTGCAGCAGCCTTAAGTGGTACCACATACCCTATCGATAGACACGAGACAA
CAGCATTGTTGAACTTTGGCAGTCTCTATGAGAATAGCCTAGATGCTGTTAGTGACAGAGACTATATTATTGAAACATTG
CATAATATTTCTTTAACGATGGTTCACTTATCACGCTTTGCAGAGGAAATTATTTTCTGGTCCACAGACGAAGCTAAATT
CATTACATTATCAGATGCATTTTCAACTGGCTCATCTATTATGCCACAAAAGAAAAATCCTGATATGGCAGAATTAATTA
GAGGTAAAGTTGGTCGAACGACTGGTCATTTAATGAGCATGCTTATGACTTTAAAAGGATTACCTCTAGCATATAACAAA
GATATGCAGGAAGATAAAGAAGGTTTATTCGATGCTGTCCATACAATTAAAGGTTCTTTACGTATTTTCGAAGGTATGAT
TCAAACGATGACAATTAATAAAGAACGACTCAATCAAACTGTTAAAGAAGATTTTTCAAATGCAACGGAACTAGCAGATT
ATTTAGTAACTAAAAATATTCCATTTAGAACTGCACATGAAATTGTAGGAAAAATCGTCTTAGAATGTATACAACAAGGT
CATTATTTATTAGATGTTCCTTTAGCAACATATCAACAACATCATTCTAGTATTGATGCCGATATTTACGATTATTTGCA
GCCTGAAAATTGTTTAAAACGACGTCAAAGTTACGGTTCAACAGGTCAATCATCGGTCAAACAACAACTTGATGTTGCTA
AACAATTACTATCACAATAA

Upstream 100 bases:

>100_bases
ACAAAAGAAGATGCATTTAATCAAGACGCTGCTGTTGGCTTTATCGATATCTATGGTTTACCTACTCAAGTAAATGCGAT
GTTGCATGGAGGCTATAGCA

Downstream 100 bases:

>100_bases
ATACGTTAATCTACCTACCCACAATGTCTATTAAAATTACATTGTGGGTATTTTAATGCTCTCTTCGTCTTGTTGAACAT
CACATTTTTAAGATTCCTAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSA
SLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQR
AQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNK
DMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQG
HYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ

Sequences:

>Translated_459_residues
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSA
SLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQR
AQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNK
DMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQG
HYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>Mature_458_residues
SNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSAS
LEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRA
QPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLH
NISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKD
MQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGH
YLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=456, Percent_Identity=42.1052631578947, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=456, Percent_Identity=42.1052631578947, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=456, Percent_Identity=40.5701754385965, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI68303547, Length=456, Percent_Identity=39.2543859649123, Blast_Score=329, Evalue=3e-90,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=48.0176211453744, Blast_Score=454, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=42.8260869565217, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=36.7256637168142, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=36.7256637168142, Blast_Score=332, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_STAA1 (A7X0H4)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441545.1
- ProteinModelPortal:   A7X0H4
- SMR:   A7X0H4
- STRING:   A7X0H4
- EnsemblBacteria:   EBSTAT00000002932
- GeneID:   5561620
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0955
- eggNOG:   COG0165
- GeneTree:   EBGT00050000024473
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   SAUR418127:SAHV_0955-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52018; Mature: 51886

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQI
CCCCCCCCEEECCHHHHHHCCCCCEEECHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHH
IQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHL
HHHHHHHHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
YTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
QQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRT
HHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCH
TGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDA
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCH
DIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
HHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQI
CCCCCCCEEECCHHHHHHCCCCCEEECHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHH
IQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHL
HHHHHHHHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
YTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
QQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRT
HHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCH
TGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDA
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCH
DIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
HHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA