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The map label for this gene is hisC

Identifier: 57651560

GI number: 57651560

Start: 807523

End: 808581

Strand: Direct

Name: hisC

Synonym: SACOL0784

Alternate gene names: 57651560

Gene position: 807523-808581 (Clockwise)

Preceding gene: 57651559

Following gene: 57651561

Centisome position: 28.74

GC content: 33.62

Gene sequence:

>1059_bases
ATGAAAGAACAACTTAATCAACTATCAGCATATCAGCCTGGTTTATCTCCAAGGGCATTGAAAGAAAAGTATGGCATTGA
AGGAGATTTATATAAACTTGCATCAAATGAAAATTTGTATGGACCATCGCCTAAAGTTAAAGAAGCGATATCAGCACACT
TAGATGAGTTATATTATTATCCTGAAACAGGATCACCGACATTAAAAGCGGCGATTAGTAAACATTTAAATGTAGATCAA
TCACGCATTTTATTTGGTGCGGGATTAGATGAAGTTATATTAATGATTTCTAGAGCTGTATTAACGCCAGGGGATACTAT
TGTTACAAGTGAAGCGACATTCGGTCAATATTATCACAATGCGATTGTTGAATCAGCTAATGTGATACAAGTACCTTTAA
AAGATGGTGGCTTCGATTTAGAAGGTATTTTAAAAGAAGTTAATGAAGATACGTCATTGGTATGGTTATGTAATCCAAAT
AATCCTACAGGTACATATTTTAATCATGAGAGCTTAGATTCGTTTTTATCTCAAGTACCTCCACATGTACCAGTAATTAT
AGATGAAGCTTATTTTGAATTTGTGACAGCAGAGGACTACCCGGATACACTTGCTTTGCAACAAAAATATGACAATGCTT
TCTTATTACGTACATTTTCAAAGGCGTATGGATTAGCGGGTTTACGTGTAGGATATGTGGTAGCAAGTGAACATGCGATT
GAAAAATGGAACATCATTAGACCACCATTTAATGTGACACGTATATCTGAATACGCAGCAGTTGCAGCACTTGAAGATCA
ACAATATTTAAAAGAGGTAACACATAAAAATAGTGTTGAACGCGAAAGATTTTATCAATTACCTCAAAGTGAGTATTTCT
TGCCAAGTCAAACGAATTTTATATTTGTAAAAACAAAGCGGGTAAATGAACTTTATGAAGCACTTTTAAATGTAGGGTGT
ATTACGCGACCATTTCCAACTGGTGTTAGAATTACAATTGGTTTTAAAGAACAAAATGATAAAATGTTAGAAGTTTTATC
AAACTTTAAATACGAATAG

Upstream 100 bases:

>100_bases
TGATGTGAAAATAGTAGCATTGCATTTTAGAAACATAGAGCGATATAATGAATATAAGTTTTTTGAAATTTCAGTTAATT
CTAAGGAGGTTGTTTTTATT

Downstream 100 bases:

>100_bases
TAAGTGGGGAGTGGGACAGAAATGATATTTTCGCAAAATTTATTTCGTCGTCCCACCCCAACTTGCATTGTCTGTAGAAA
TTGGGAATCCAATTTCTCTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQ
SRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPN
NPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAI
EKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGC
ITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE

Sequences:

>Translated_352_residues
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQ
SRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPN
NPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAI
EKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGC
ITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
>Mature_352_residues
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQ
SRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPN
NPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAI
EKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGC
ITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=348, Percent_Identity=29.0229885057471, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788722, Length=275, Percent_Identity=24.7272727272727, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=352, Percent_Identity=25.5681818181818, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_STAA1 (A7WZL0)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441311.1
- ProteinModelPortal:   A7WZL0
- STRING:   A7WZL0
- EnsemblBacteria:   EBSTAT00000003778
- GeneID:   5561132
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0721
- eggNOG:   COG0079
- GeneTree:   EBGT00050000024045
- HOGENOM:   HBG646350
- OMA:   MIEVLKH
- ProtClustDB:   PRK03158
- BioCyc:   SAUR418127:SAHV_0721-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39788; Mature: 39788

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYY
CCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEC
PETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHN
CCCCCHHHHHHHHHHCCCCHHHEEEECCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
AIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVP
HHHCCCCEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
PHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAI
CCCCEEECCHHHHEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCHHH
EKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEECCCCCCE
IFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
EEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYY
CCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEC
PETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHN
CCCCCHHHHHHHHHHCCCCHHHEEEECCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
AIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVP
HHHCCCCEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
PHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAI
CCCCEEECCHHHHEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCHHH
EKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEECCCCCCE
IFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
EEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA