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The map label for this gene is phr [H]

Identifier: 57651532

GI number: 57651532

Start: 772720

End: 774093

Strand: Direct

Name: phr [H]

Synonym: SACOL0751

Alternate gene names: 57651532

Gene position: 772720-774093 (Clockwise)

Preceding gene: 57651531

Following gene: 57651535

Centisome position: 27.5

GC content: 33.92

Gene sequence:

>1374_bases
ATGGCAATTGCTGTGTTATTAAATCGAATGTTTCGAATGGAACACAATCCATTATTTGAATATATTTATCAACAAAAAGA
AGACATTGATGCATGTTATTTTATCATTCCGGAAGAGGACATGTCTTCAGCTTCTGATTTGAAAGCACAGTTTTATCGCG
GTACTTTGCAGCGCTTTTACCAATCGTTGCACGCAGAAAAGCTTACACCTTATGTTATGTCTTATGACGATATCATTTCA
TTTTGTAAAGAAAACAATATCTCTGAAGTAGTGACTGCGGGTGATATTATGAGTTATCATCTTGAAGAATATGATATTTT
ACATCAACGTTCTTTATTCAATGAAGCACGCATTGCCGTTACTTTGATACGTGGGAATCATTACTTTAAAGCGAGTAAAA
CAATGAATCAACAAGGGGAGCCATACAATGTTTTTACTAGTTTCTATAAAAAATGGCGACCTTACTTGAGGCATAGAGAC
GTATATCACTATGATTTAAAATCATTCGAAGACTTTGTCATTGCATCACCTGATGATTTAGTGTTTGATGACATAGCATT
TGGATCCTCACAAATAATTGAACAGAATAAATGGCAACATTTTTTAGATCAAGATATACAGAATTACGAAAGCGGAAGAG
ACTATTTACCTGAAGTATTAACAAGTCAGCTAAGTGTTGCTTTAGCATATGGATTATTAGATATTATTGAAATTTTTAAT
GATTTATTGGCGCGTTATGATGAAGATGAGGCAAACTATGAAGCATTTATACGTGAACTCATTTTTAGAGAATTTTATTA
TGTGTTAATGACACAGTATCCTGAAACCTCATACCAAGCTTTCAAACCTAAATATCGACAGATAAAATGGTCGCAAAATG
AAGCGGATTTTAATGCATGGTGCGAAGGGCAAACAGGATTTCCAATCATTGATGCAGCAATAATGGAATTGACACAAACT
GGTTTTATGCATAATCGAATGAGAATGGTTGTGTCGCAATTTTTAACCAAAGATTTATTTATAGATTGGACATGGGGAGA
AAAATTCTTTAGAAAGCACCTTATTGACTATGATGCAGCATCAAATATTCATGGATGGCAATGGTCTGCTTCTACAGGTA
CGGATGCAGTGCCGTATTTTAGAATGTTTAATCCAATAAGACAGAGTGAACGCTTTGATGCTAAAGCTTTGTATATCAAA
ACATATCTTCCGATTTTTAATCAAATTGATGCAAAATATTTGCATGATACACAACGCAATGAGTCCAACCTTTTTGAACA
GGGGATTGAATTAGGTAGTCATTATCCAAGACAAATGGTAGATCATCAAGAAAAACGTACACAAGTTTTAGCTACATTTA
AAGCGCTAGACTAA

Upstream 100 bases:

>100_bases
TTAGGTTTGCTTTAATTAAAAATATAAATAAGAATCTAGGTTATTTTAAAGTGACAAAAAGCTTAATAAAATAAAAAGAT
AATTGAAGGGTGTTTTGTTT

Downstream 100 bases:

>100_bases
TTCGGCTCAATTGATAGATCTGGCATGAGTAAAATCTGGAGCAGAATATAAAGTTCTTAAGCAATATAAATAAGCCAATT
TCTATTATTGATGTGATAGA

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MAIAVLLNRMFRMEHNPLFEYIYQQKEDIDACYFIIPEEDMSSASDLKAQFYRGTLQRFYQSLHAEKLTPYVMSYDDIIS
FCKENNISEVVTAGDIMSYHLEEYDILHQRSLFNEARIAVTLIRGNHYFKASKTMNQQGEPYNVFTSFYKKWRPYLRHRD
VYHYDLKSFEDFVIASPDDLVFDDIAFGSSQIIEQNKWQHFLDQDIQNYESGRDYLPEVLTSQLSVALAYGLLDIIEIFN
DLLARYDEDEANYEAFIRELIFREFYYVLMTQYPETSYQAFKPKYRQIKWSQNEADFNAWCEGQTGFPIIDAAIMELTQT
GFMHNRMRMVVSQFLTKDLFIDWTWGEKFFRKHLIDYDAASNIHGWQWSASTGTDAVPYFRMFNPIRQSERFDAKALYIK
TYLPIFNQIDAKYLHDTQRNESNLFEQGIELGSHYPRQMVDHQEKRTQVLATFKALD

Sequences:

>Translated_457_residues
MAIAVLLNRMFRMEHNPLFEYIYQQKEDIDACYFIIPEEDMSSASDLKAQFYRGTLQRFYQSLHAEKLTPYVMSYDDIIS
FCKENNISEVVTAGDIMSYHLEEYDILHQRSLFNEARIAVTLIRGNHYFKASKTMNQQGEPYNVFTSFYKKWRPYLRHRD
VYHYDLKSFEDFVIASPDDLVFDDIAFGSSQIIEQNKWQHFLDQDIQNYESGRDYLPEVLTSQLSVALAYGLLDIIEIFN
DLLARYDEDEANYEAFIRELIFREFYYVLMTQYPETSYQAFKPKYRQIKWSQNEADFNAWCEGQTGFPIIDAAIMELTQT
GFMHNRMRMVVSQFLTKDLFIDWTWGEKFFRKHLIDYDAASNIHGWQWSASTGTDAVPYFRMFNPIRQSERFDAKALYIK
TYLPIFNQIDAKYLHDTQRNESNLFEQGIELGSHYPRQMVDHQEKRTQVLATFKALD
>Mature_456_residues
AIAVLLNRMFRMEHNPLFEYIYQQKEDIDACYFIIPEEDMSSASDLKAQFYRGTLQRFYQSLHAEKLTPYVMSYDDIISF
CKENNISEVVTAGDIMSYHLEEYDILHQRSLFNEARIAVTLIRGNHYFKASKTMNQQGEPYNVFTSFYKKWRPYLRHRDV
YHYDLKSFEDFVIASPDDLVFDDIAFGSSQIIEQNKWQHFLDQDIQNYESGRDYLPEVLTSQLSVALAYGLLDIIEIFND
LLARYDEDEANYEAFIRELIFREFYYVLMTQYPETSYQAFKPKYRQIKWSQNEADFNAWCEGQTGFPIIDAAIMELTQTG
FMHNRMRMVVSQFLTKDLFIDWTWGEKFFRKHLIDYDAASNIHGWQWSASTGTDAVPYFRMFNPIRQSERFDAKALYIKT
YLPIFNQIDAKYLHDTQRNESNLFEQGIELGSHYPRQMVDHQEKRTQVLATFKALD

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=246, Percent_Identity=31.7073170731707, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI188536100, Length=246, Percent_Identity=29.6747967479675, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI188536103, Length=246, Percent_Identity=30.0813008130081, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1786926, Length=399, Percent_Identity=33.5839598997494, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324962, Length=493, Percent_Identity=28.8032454361055, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI17137248, Length=235, Percent_Identity=31.4893617021277, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24585455, Length=235, Percent_Identity=31.4893617021277, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24648152, Length=202, Percent_Identity=28.7128712871287, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54371; Mature: 54240

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAVLLNRMFRMEHNPLFEYIYQQKEDIDACYFIIPEEDMSSASDLKAQFYRGTLQRFY
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCHHCCCHHHHHHHHHHHHHHHHH
QSLHAEKLTPYVMSYDDIISFCKENNISEVVTAGDIMSYHLEEYDILHQRSLFNEARIAV
HHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TLIRGNHYFKASKTMNQQGEPYNVFTSFYKKWRPYLRHRDVYHYDLKSFEDFVIASPDDL
EEEECCEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEECHHCCCCEEEECCCCC
VFDDIAFGSSQIIEQNKWQHFLDQDIQNYESGRDYLPEVLTSQLSVALAYGLLDIIEIFN
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLARYDEDEANYEAFIRELIFREFYYVLMTQYPETSYQAFKPKYRQIKWSQNEADFNAW
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHCEECCCCCCCCCCE
CEGQTGFPIIDAAIMELTQTGFMHNRMRMVVSQFLTKDLFIDWTWGEKFFRKHLIDYDAA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHCCCCC
SNIHGWQWSASTGTDAVPYFRMFNPIRQSERFDAKALYIKTYLPIFNQIDAKYLHDTQRN
CCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
ESNLFEQGIELGSHYPRQMVDHQEKRTQVLATFKALD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIAVLLNRMFRMEHNPLFEYIYQQKEDIDACYFIIPEEDMSSASDLKAQFYRGTLQRFY
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCHHCCCHHHHHHHHHHHHHHHHH
QSLHAEKLTPYVMSYDDIISFCKENNISEVVTAGDIMSYHLEEYDILHQRSLFNEARIAV
HHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TLIRGNHYFKASKTMNQQGEPYNVFTSFYKKWRPYLRHRDVYHYDLKSFEDFVIASPDDL
EEEECCEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEECHHCCCCEEEECCCCC
VFDDIAFGSSQIIEQNKWQHFLDQDIQNYESGRDYLPEVLTSQLSVALAYGLLDIIEIFN
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLARYDEDEANYEAFIRELIFREFYYVLMTQYPETSYQAFKPKYRQIKWSQNEADFNAW
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHCEECCCCCCCCCCE
CEGQTGFPIIDAAIMELTQTGFMHNRMRMVVSQFLTKDLFIDWTWGEKFFRKHLIDYDAA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHCCCCC
SNIHGWQWSASTGTDAVPYFRMFNPIRQSERFDAKALYIKTYLPIFNQIDAKYLHDTQRN
CCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
ESNLFEQGIELGSHYPRQMVDHQEKRTQVLATFKALD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]