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The map label for this gene is mvaD

Identifier: 57651466

GI number: 57651466

Start: 669084

End: 670067

Strand: Direct

Name: mvaD

Synonym: SACOL0637

Alternate gene names: NA

Gene position: 669084-670067 (Clockwise)

Preceding gene: 57651465

Following gene: 57650049

Centisome position: 23.82

GC content: 36.99

Gene sequence:

>984_bases
TTGATTAAAAGTGGCAAAGCACGTGCACATACGAATATTGCACTTATAAAATATTGGGGTAAAAAAGATGAAGCACTAAT
CATTCCAATGAATAATAGCATATCTGTTACATTAGAAAAATTTTACACTGAAACGAAAGTCACTTTTAACGACCAGTTAA
CACAGGATCAATTTTGGTTGAATGGTGAAAAGGTTAGTGGCAAAGAATTAGAGAAAATTTCAAAATATATGGATATTGTC
AGAAATAGAGCTGGCATCGATTGGTATGCAGAAATTGAAAGCGACAATTTTGTACCAACAGCAGCAGGGTTGGCTTCATC
GGCAAGCGCATATGCAGCTTTAGCAGCAGCTTGTAATCAAGCGCTAGACATGCAGCTGTCAGATAAGGATTTATCGAGAT
TGGCGCGAATTGGTTCGGGTTCTGCGTCGCGTAGTATTTATGGTGGATTTGCAGAATGGGAAAAAGGGTATAGTGATGAG
ACGTCATATGCCGTTCCACTTGAATCGAATCATTTTGAAGATGACCTTGCCATGATATTTGTTGTGATTAATCAACATTC
TAAAAAGGTACCTAGTCGATATGGTATGTCATTGACACGAAACACATCAAGGTTTTATCAATATTGGTTAGATCATATTG
ATGAAGATTTAGCTGAAGCAAAAGCAGCGATTCAAGACAAAGATTTTAAACGCCTTGGTGAAGTAATTGAAGAAAATGGT
TTGCGTATGCATGCCACGAATCTAGGATCAACACCGCCGTTCACATATCTTGTGCAAGAAAGTTATGATGTCATGGCGCT
TGTTCACGAATGCCGAGAAGCGGGGTATCCGTGTTATTTTACAATGGATGCGGGACCTAATGTGAAAATACTTGTAGAAA
AGAAAAACAAGCAACAGATTATAGATAAATTATTAACACAGTTTGATAATAACCAAATTATTGATAGTGACATTATTGCC
ACAGGAATTGAAATAATTGAGTAA

Upstream 100 bases:

>100_bases
TTGCTTGCCAAAGATTTACCAACAGCGAAAAATATTGTAAAAGCTGTAGAAAAAGCTGGTGCAGCACATACTTGGATTGA
GAATTTAGGAGGTTAATGCG

Downstream 100 bases:

>100_bases
GGAAGAGATAAAATGATTCAGGTCAAAGCACCCGGAAAACTTTATATTGCTGGAGAATATGCTGTAACAGAACCAGGATA
TAAATCTGTACTTATTGCGT

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIV
RNRAGIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDMQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYSDE
TSYAVPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG
LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIDSDIIA
TGIEIIE

Sequences:

>Translated_327_residues
MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIV
RNRAGIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDMQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYSDE
TSYAVPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG
LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIDSDIIA
TGIEIIE
>Mature_327_residues
MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIV
RNRAGIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDMQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYSDE
TSYAVPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG
LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIDSDIIA
TGIEIIE

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=305, Percent_Identity=34.4262295081967, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17537201, Length=342, Percent_Identity=33.9181286549708, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17537203, Length=207, Percent_Identity=34.7826086956522, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324371, Length=320, Percent_Identity=32.5, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571205, Length=333, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 36823; Mature: 36823

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWL
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEHHHCCCEEEECCCCCCCCEEE
NGEKVSGKELEKISKYMDIVRNRAGIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHH
ALDMQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYSDETSYAVPLESNHFEDDLAMIF
HHCCEECHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCCCCCHHHEEEE
VVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG
EEECCCCCCCHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQI
CEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHH
IDKLLTQFDNNQIIDSDIIATGIEIIE
HHHHHHHCCCCCEECHHHHHHHHHHCC
>Mature Secondary Structure
MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWL
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEHHHCCCEEEECCCCCCCCEEE
NGEKVSGKELEKISKYMDIVRNRAGIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHH
ALDMQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYSDETSYAVPLESNHFEDDLAMIF
HHCCEECHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCCCCCHHHEEEE
VVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG
EEECCCCCCCHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQI
CEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHH
IDKLLTQFDNNQIIDSDIIATGIEIIE
HHHHHHHCCCCCEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA