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The map label for this gene is atoB [H]

Identifier: 57651451

GI number: 57651451

Start: 656124

End: 657263

Strand: Direct

Name: atoB [H]

Synonym: SACOL0622

Alternate gene names: 57651451

Gene position: 656124-657263 (Clockwise)

Preceding gene: 57651450

Following gene: 57651452

Centisome position: 23.35

GC content: 38.42

Gene sequence:

>1140_bases
ATGAATCAAGCAGTCATAGTTGCAGCTAAACGAACTGCATTTGGGAAATATGGTGGCACTTTAAAACATTTAGAGCCAGA
ACAATTGCTTAAACCTTTATTCCAACATTTTAAAGAGAAGTATCCAGAGGTAATATCTAAAATAGATGATGTAGTTTTAG
GTAATGTTGTTGGGAATGGTGGCAATATTGCAAGAAAAGCATTGCTTGAAGCGGGGCTTAAAGATTCAATACCTGGCGTC
ACAATCGATCGGCAATGTGGGTCTGGACTTGAAAGTGTTCAATATGCATGTCGCATGATCCAAGCCGGAGCTGGCAAGGT
ATATATTGCAGGTGGTGTTGAAAGTACAAGTCGAGCACCTTGGAAAATCAAACGACCGCATTCTGTGTACGAAACAGCAT
TACCTGAGTTTTATGAGCGTGCATCATTTGCACCTGAAATGAGCGACCCATCAATGATTCAAGGTGCTGAAAATGTGGCC
AAGATGTATGATGTTTCAAGAGGATTACAAGATGAATTTGCTTATCGAAGTCATCAATTGACAGCGGAAAATGTAAAGAA
TGGAAATATTTCTCAGGAAATATTACCTATAACCGTTAAAGGAGAAATATTCAACACTGATGAAAGTCTAAAATCACATA
TTCCGAAAGATAACTTTGGCCGATTTAAGCCCGTGATCAAAGGTGGGACCGTTACCGCTGCGAATAGTTGTATGAAAAAT
GATGGTGCAGTTTTATTGCTTATTATGGAAAAAGATATGGCATACGAATTAGGTTTCGAGCATGGTTTATTATTTAAAGA
TGGTGTTACGGTAGGTGTTGATTCTAATTTTCCTGGCATTGGTCCAGTACCAGCCATTTCCAACTTACTAAAAAGAAATC
AATTAACGATAGAAAATATTGAAGTCATTGAAATTAACGAAGCGTTCAGTGCACAGGTAGTTGCCTGCCAACAAGCTTTA
AATATTTCAAATACGCAATTAAATATATGGGGTGGTGCATTAGCATCAGGTCATCCATACGGTGCAAGCGGTGCCCAATT
AGTGACTCGATTATTTTATATGTTTGACAAAGAGACTATGATTGCATCTATGGGGATAGGGGGAGGTCTAGGAAATGCAG
CATTATTTACTCGATTCTAA

Upstream 100 bases:

>100_bases
CCATCGATGATTCATCATGTAGAAAAGATGTATTACACTGCAAGTGGTAAAATTGCTAGAGAAAAAATGATGTCGATGTA
TTTGAGAGGTGAATTATAAT

Downstream 100 bases:

>100_bases
CCAGCGATTAAATGTGTCATTTTCTAAGGATAGTGTGGCTGCATATTATCAGTGTTTTAACCAACCTTATAGAAAAGAAG
TACCACCATTAATGTGTGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNQAVIVAAKRTAFGKYGGTLKHLEPEQLLKPLFQHFKEKYPEVISKIDDVVLGNVVGNGGNIARKALLEAGLKDSIPGV
TIDRQCGSGLESVQYACRMIQAGAGKVYIAGGVESTSRAPWKIKRPHSVYETALPEFYERASFAPEMSDPSMIQGAENVA
KMYDVSRGLQDEFAYRSHQLTAENVKNGNISQEILPITVKGEIFNTDESLKSHIPKDNFGRFKPVIKGGTVTAANSCMKN
DGAVLLLIMEKDMAYELGFEHGLLFKDGVTVGVDSNFPGIGPVPAISNLLKRNQLTIENIEVIEINEAFSAQVVACQQAL
NISNTQLNIWGGALASGHPYGASGAQLVTRLFYMFDKETMIASMGIGGGLGNAALFTRF

Sequences:

>Translated_379_residues
MNQAVIVAAKRTAFGKYGGTLKHLEPEQLLKPLFQHFKEKYPEVISKIDDVVLGNVVGNGGNIARKALLEAGLKDSIPGV
TIDRQCGSGLESVQYACRMIQAGAGKVYIAGGVESTSRAPWKIKRPHSVYETALPEFYERASFAPEMSDPSMIQGAENVA
KMYDVSRGLQDEFAYRSHQLTAENVKNGNISQEILPITVKGEIFNTDESLKSHIPKDNFGRFKPVIKGGTVTAANSCMKN
DGAVLLLIMEKDMAYELGFEHGLLFKDGVTVGVDSNFPGIGPVPAISNLLKRNQLTIENIEVIEINEAFSAQVVACQQAL
NISNTQLNIWGGALASGHPYGASGAQLVTRLFYMFDKETMIASMGIGGGLGNAALFTRF
>Mature_379_residues
MNQAVIVAAKRTAFGKYGGTLKHLEPEQLLKPLFQHFKEKYPEVISKIDDVVLGNVVGNGGNIARKALLEAGLKDSIPGV
TIDRQCGSGLESVQYACRMIQAGAGKVYIAGGVESTSRAPWKIKRPHSVYETALPEFYERASFAPEMSDPSMIQGAENVA
KMYDVSRGLQDEFAYRSHQLTAENVKNGNISQEILPITVKGEIFNTDESLKSHIPKDNFGRFKPVIKGGTVTAANSCMKN
DGAVLLLIMEKDMAYELGFEHGLLFKDGVTVGVDSNFPGIGPVPAISNLLKRNQLTIENIEVIEINEAFSAQVVACQQAL
NISNTQLNIWGGALASGHPYGASGAQLVTRLFYMFDKETMIASMGIGGGLGNAALFTRF

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=31.6326530612245, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=32.4742268041237, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4501853, Length=389, Percent_Identity=31.6195372750643, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=33.7531486146096, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4504327, Length=413, Percent_Identity=28.3292978208232, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=35.5, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=36.3867684478371, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=31.4578005115089, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=24.455205811138, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=35.2185089974293, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=30.4964539007092, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=29.639175257732, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=27.2040302267003, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17535917, Length=368, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322031, Length=385, Percent_Identity=34.025974025974, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=392, Percent_Identity=29.0816326530612, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=31.7135549872123, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=33.7628865979381, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=32.0512820512821, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=29.9765807962529, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 41023; Mature: 41023

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQAVIVAAKRTAFGKYGGTLKHLEPEQLLKPLFQHFKEKYPEVISKIDDVVLGNVVGNG
CCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GNIARKALLEAGLKDSIPGVTIDRQCGSGLESVQYACRMIQAGAGKVYIAGGVESTSRAP
CHHHHHHHHHCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
WKIKRPHSVYETALPEFYERASFAPEMSDPSMIQGAENVAKMYDVSRGLQDEFAYRSHQL
EEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
TAENVKNGNISQEILPITVKGEIFNTDESLKSHIPKDNFGRFKPVIKGGTVTAANSCMKN
CHHHCCCCCCCCEEEEEEEECEEECCHHHHHHCCCCCCCCCCCCEECCCCEEHHHHHHCC
DGAVLLLIMEKDMAYELGFEHGLLFKDGVTVGVDSNFPGIGPVPAISNLLKRNQLTIENI
CCCEEEEEECCCCHHHCCCCCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCEECCE
EVIEINEAFSAQVVACQQALNISNTQLNIWGGALASGHPYGASGAQLVTRLFYMFDKETM
EEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHH
IASMGIGGGLGNAALFTRF
HEECCCCCCCCCCHHEECC
>Mature Secondary Structure
MNQAVIVAAKRTAFGKYGGTLKHLEPEQLLKPLFQHFKEKYPEVISKIDDVVLGNVVGNG
CCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GNIARKALLEAGLKDSIPGVTIDRQCGSGLESVQYACRMIQAGAGKVYIAGGVESTSRAP
CHHHHHHHHHCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
WKIKRPHSVYETALPEFYERASFAPEMSDPSMIQGAENVAKMYDVSRGLQDEFAYRSHQL
EEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
TAENVKNGNISQEILPITVKGEIFNTDESLKSHIPKDNFGRFKPVIKGGTVTAANSCMKN
CHHHCCCCCCCCEEEEEEEECEEECCHHHHHHCCCCCCCCCCCCEECCCCEEHHHHHHCC
DGAVLLLIMEKDMAYELGFEHGLLFKDGVTVGVDSNFPGIGPVPAISNLLKRNQLTIENI
CCCEEEEEECCCCHHHCCCCCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCEECCE
EVIEINEAFSAQVVACQQALNISNTQLNIWGGALASGHPYGASGAQLVTRLFYMFDKETM
EEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHH
IASMGIGGGLGNAALFTRF
HEECCCCCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]