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The map label for this gene is yciC [H]

Identifier: 57651332

GI number: 57651332

Start: 491048

End: 492250

Strand: Direct

Name: yciC [H]

Synonym: SACOL0491

Alternate gene names: 57651332

Gene position: 491048-492250 (Clockwise)

Preceding gene: 57651330

Following gene: 57651333

Centisome position: 17.48

GC content: 37.07

Gene sequence:

>1203_bases
ATGGCTAAAATTCCAGTTACGGTATTAAGTGGTTATTTAGGCTCGGGGAAGACAACGTTGTTAAATCATATTTTACAAAA
TCGAGAAGGTCGACGTATCGCGGTAATTGTAAATGATATGAGTGAAGTAAATATCGATAAAGATCTTGTCGCAGATGGTG
GGGGACTATCGCGTACAGATGAAAAATTAGTCGAACTTTCTAATGGTTGTATCTGTTGTACACTTAGAGACGATTTATTA
AAAGAAGTTGAGCGTTTAGTGAAAAAAGGTGGCATCGATCAAATTGTTATTGAGTCAACAGGGATTTCAGAGCCAGTACC
TGTTGCACAAACTTTCTCATATATTGATGATGAACTTGGCATTGATCTTACAGCGATTTGCCGTTTAGATACAATGGTTA
CAGTTGTGGATGCTAACCGCTTCGTACATGACATCAACTCAGAAGATTTATTGATGGATCGTGATCAAAGCGTTGACGAA
ACAGATGAGCGTTCGATTGCTGATTTATTAATTGACCAAGTTGAATTTTGTGATGTATTGATTATTAATAAAATTGATTT
AATTAGTGAAGAAGAACTAGCGAAGTTAGAAAAAATGTTAAGCGCATTGCAACCGACTGCTAAAATTATTAAGACAACAA
ATTCTGAAGTAGATTTAAAAGAAGTCTTGAATACGCAGCGTTTTGATTTTGAAAAAGCGAGCGAGTCAGCAGGATGGATC
AAAGAACTTGAGTCTGGTGGGCATGCATCGCATACACCTGAAACAGAAGAATATGGTATATCATCGTTTGTATATAAACG
TCGTCTACCTTTCCATGCTAAAAGGTTCAATGATTGGTTAGAAAGCATGCCAAATAATGTCGTTCGATCAAAAGGTATCG
TATGGCTAGCACAATACAATCACGTAGCATGTTTATTATCTCAAGCAGGGTCATCTTGCAATATTCATCCAGTTACATAT
TGGGTGGCTAGTATGTCTGAAGCGCAACAAACACAAATATTAGCAGAACGTCAAGATGTCGCAGCTGAATGGGATCCAGA
ATATGGCGATCGTCATACACAATTTGTCATTATTGGTACAGAATTAGATGAAGAAAAATTAACAAAAGAACTCGACGCAT
GCTTAGTCAATGCGCAAGAAATTGATGCAGATTGGCAACAATTTGAAGATCCATATCAATGGCAAATTAGACCAGCACGA
TAA

Upstream 100 bases:

>100_bases
TATTTTTTTATTATCGAAGATTGCGAAAGAGGAAACGCTCCTATATAATGTAAAACGGAATTATTCCTATTTGCAAATAA
ATTGAAGTGAGGGTATATAT

Downstream 100 bases:

>100_bases
GTTGAATGAAGTATAATCATTTTTGAATTGTGGCTTAATTGTTTGCAATTTATGACAATTAATAAAAAGTTAAGGTGTTC
TTAGGATCTTTTTGTTTTCA

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTDEKLVELSNGCICCTLRDDLL
KEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELGIDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDE
TDERSIADLLIDQVEFCDVLIINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYNHVACLLSQAGSSCNIHPVTY
WVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGTELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR

Sequences:

>Translated_400_residues
MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTDEKLVELSNGCICCTLRDDLL
KEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELGIDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDE
TDERSIADLLIDQVEFCDVLIINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYNHVACLLSQAGSSCNIHPVTY
WVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGTELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
>Mature_399_residues
AKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTDEKLVELSNGCICCTLRDDLLK
EVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELGIDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDET
DERSIADLLIDQVEFCDVLIINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWIK
ELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYNHVACLLSQAGSSCNIHPVTYW
VASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGTELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI146231952, Length=230, Percent_Identity=38.695652173913, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI148727351, Length=230, Percent_Identity=38.2608695652174, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI33469141, Length=230, Percent_Identity=38.2608695652174, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI126722884, Length=230, Percent_Identity=38.2608695652174, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI223941779, Length=229, Percent_Identity=37.117903930131, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI223941776, Length=218, Percent_Identity=36.2385321100917, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI119120938, Length=149, Percent_Identity=42.2818791946309, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI87082430, Length=381, Percent_Identity=27.2965879265092, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788499, Length=234, Percent_Identity=27.3504273504274, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324356, Length=238, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45048; Mature: 44917

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
CCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHCCCCCCCHHH
EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
HHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHC
IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
CCHHHHHHHHHEEEEEECHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCEE
IINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
EECCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHCCCCCCHHHHCCCHHHH
KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYN
HHHHCCCCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCEEEEEECC
HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
CCCHHHHHHHHHHHHHCHHHCCCCHHHCCCCCEEEEEECC
>Mature Secondary Structure 
AKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
CCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHCCCCCCCHHH
EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
HHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHC
IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
CCHHHHHHHHHEEEEEECHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCEE
IINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
EECCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHCCCCCCHHHHCCCHHHH
KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYN
HHHHCCCCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCEEEEEECC
HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
CCCHHHHHHHHHHHHHCHHHCCCCHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]