Click here to switch to the map view.

The map label for this gene is ipdC [H]

Identifier: 57651189

GI number: 57651189

Start: 198662

End: 200302

Strand: Reverse

Name: ipdC [H]

Synonym: SACOL0173

Alternate gene names: 57651189

Gene position: 200302-198662 (Counterclockwise)

Preceding gene: 57651191

Following gene: 57651188

Centisome position: 7.13

GC content: 36.5

Gene sequence:

>1641_bases
ATGAAACAACGCATTGGAGCTTACTTAATTGACGCTATTCATCGAGCAGGCGTCGATAAAATTTTTGGTGTTCCTGGTGA
TTTTAATCTCGCTTTTCTAGACGATATTATCAGCAATCCCAATGTAGATTGGGTAGGAAATACAAATGAATTAAACGCAA
GTTACGCAGCGGACGGTTATGCCCGTCTTAATGGACTCGCTGCATTAGTTACTACATTTGGTGTTGGCGAATTAAGTGCC
GTCAACGGTATCGCAGGTTCATATGCTGAACGCATACCTGTCATTGCGATTACAGGTGCGCCGACACGTGCTGTTGAACA
AGGCGGTAAATATGTACATCACTCACTTGGTGAAGGTACATTTGACGACTATCGAAAAATGTTTGCACATATAACCGTTG
CACAAGGTTATATCACACCTGAAAATGCAACAACCGAAATACCACGTTTAATTAATACAGCAATCGCCGAAAGACGCCCA
GTTCATTTACATTTACCAATCGATGTCGCAATCTCTGAAATTGAGATACCGACACCATTTGAAGTGACGGCAACTAAATA
TACGGATGCATCAACATATATAGAGTTATTAGCAACTAAACTGCATCAAGCGAAGCAGCCTATCATCATTACTGGACATG
AAATTAACAGTTTTCACCTCCATCAAGAATTAGAAGATTTTGTAAATCAAACACAGATACCAGTAGCACAACTTTCATTA
GGAAAAGGTGCTTTTAATGAGGAAAATCCATATTATATGGGTATTTACGATGGGAAAATTGCCGAAGATAAAATACGAGA
TTATGTGGACAACAGCGATTTAATTTTAAATATTGGAGCCAAATTAACAGATTCAGCAACAGCAGGTTTTTCATACCAAT
TCAATATCGATGATGTCGTTATGTTAAATCATCACAATATCAAAATTGACGATGTTACAAATGATGAAATATCTCTACCA
TCATTGTTAAAACAGTTATCCAATATTTCATATACGAATAACGCAACGTTCCCTGCGTATCATCGTCCAACATCACCCGA
TTATACTGTTGGCACAGAACCATTAACACAACAAACTTATTTTAAAATGATGCAAAATTTCTTAAAACCAAATGATGTCA
TCATTGCTGATCAAGGTACATCATTCTTTGGTGCTTATGATTTAGCATTATACAAAAACAATACTTTTATAGGGCAACCG
TTATGGGGTTCTATCGGCTATACATTACCTGCAACATTAGGTTCACAATTAGCAGACAAAGATCGTCGTAACTTATTATT
AATTGGTGATGGCTCATTGCAACTAACTGTTCAAGCTATTTCAACTATGATTAGACAGCATATTAAACCGGTATTATTTG
TGATTAATAATGACGGCTATACGGTAGAACGACTTATTCACGGCATGTATGAACCTTATAATGAAATTCACATGTGGGAT
TATAAAGCTTTACCAGCTGTATTTGGTGGTAAAAATGTTGAAATTCATGACGTTGAATCATCAAAAGATTTACAAGACAC
GTTTAATGCAATTAATGGTCATCCCGATGTGATGCATTTTGTCGAAGTCAAAATGGCTGTCGAAGACGCACCGAAGAAAC
TCATCGATATCGCTAAAGCTTTTTCACAACAAAATAAATAA

Upstream 100 bases:

>100_bases
TATTGTTAGCGTTTTCACAACAAAGTCAACTTCCTTGACCTTACACTATATTCGAGGCTATCATTTTAAGTGTAAATATA
GAGAAAAGGTGGCTTTTTTT

Downstream 100 bases:

>100_bases
TTTCATCGTATACAGGGTATAAGTTTAAGCGAATACTTTATTAAACGAATAGGACTCTGATATAAGATGATTAATTTTAA
TAAAACCGCTTTAGTGTTAA

Product: indole-3-pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKQRIGAYLIDAIHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSA
VNGIAGSYAERIPVIAITGAPTRAVEQGGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRP
VHLHLPIDVAISEIEIPTPFEVTATKYTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLP
SLLKQLSNISYTNNATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQP
LWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMAVEDAPKKLIDIAKAFSQQNK

Sequences:

>Translated_546_residues
MKQRIGAYLIDAIHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSA
VNGIAGSYAERIPVIAITGAPTRAVEQGGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRP
VHLHLPIDVAISEIEIPTPFEVTATKYTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLP
SLLKQLSNISYTNNATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQP
LWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMAVEDAPKKLIDIAKAFSQQNK
>Mature_546_residues
MKQRIGAYLIDAIHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSA
VNGIAGSYAERIPVIAITGAPTRAVEQGGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRP
VHLHLPIDVAISEIEIPTPFEVTATKYTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLP
SLLKQLSNISYTNNATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQP
LWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMAVEDAPKKLIDIAKAFSQQNK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=474, Percent_Identity=23.6286919831224, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787096, Length=570, Percent_Identity=22.9824561403509, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786717, Length=474, Percent_Identity=21.3080168776371, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788716, Length=465, Percent_Identity=20.2150537634409, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323073, Length=560, Percent_Identity=39.4642857142857, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321524, Length=557, Percent_Identity=38.9587073608618, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323163, Length=566, Percent_Identity=37.9858657243816, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320123, Length=567, Percent_Identity=32.2751322751323, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6320588, Length=601, Percent_Identity=27.7870216306156, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323755, Length=510, Percent_Identity=23.3333333333333, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 60539; Mature: 60539

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRIGAYLIDAIHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGY
CCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
ARLNGLAALVTTFGVGELSAVNGIAGSYAERIPVIAITGAPTRAVEQGGKYVHHSLGEGT
HHHHHHHHHHHHCCCCCHHHHHCHHHHHHHCCCEEEEECCCHHHHHCCCCEEHHHCCCCC
FDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRPVHLHLPIDVAISEIEIPTPF
HHHHHHHHHHEEEECCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCC
EVTATKYTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
EEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEC
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVV
CCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCEEE
MLNHHNIKIDDVTNDEISLPSLLKQLSNISYTNNATFPAYHRPTSPDYTVGTEPLTQQTY
EEECCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
FKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQPLWGSIGYTLPATLGSQLADK
HHHHHHHCCCCCEEEECCCCCEEEEEEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHCC
DRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
CCCCEEEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCHHHEEEEC
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMAVEDAPKKLIDIAKA
CHHCHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FSQQNK
HHHCCC
>Mature Secondary Structure
MKQRIGAYLIDAIHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGY
CCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
ARLNGLAALVTTFGVGELSAVNGIAGSYAERIPVIAITGAPTRAVEQGGKYVHHSLGEGT
HHHHHHHHHHHHCCCCCHHHHHCHHHHHHHCCCEEEEECCCHHHHHCCCCEEHHHCCCCC
FDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRPVHLHLPIDVAISEIEIPTPF
HHHHHHHHHHEEEECCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCC
EVTATKYTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
EEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEC
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVV
CCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCEEE
MLNHHNIKIDDVTNDEISLPSLLKQLSNISYTNNATFPAYHRPTSPDYTVGTEPLTQQTY
EEECCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
FKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQPLWGSIGYTLPATLGSQLADK
HHHHHHHCCCCCEEEECCCCCEEEEEEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHCC
DRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
CCCCEEEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCHHHEEEEC
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMAVEDAPKKLIDIAKA
CHHCHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FSQQNK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]