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The map label for this gene is hutU

Identifier: 57650873

GI number: 57650873

Start: 2385739

End: 2387400

Strand: Reverse

Name: hutU

Synonym: SACOL2324

Alternate gene names: 57650873

Gene position: 2387400-2385739 (Counterclockwise)

Preceding gene: 57650876

Following gene: 57650872

Centisome position: 84.98

GC content: 39.53

Gene sequence:

>1662_bases
ATGAGAAAAATTCAAGCAAAAAAAGGTTTGAGTATTGAGTGTAAAGGTTGGGAACAAGAAGCAGTACTTAGAATGTTATA
CAACAATTTAGACCCAGAAGTTGCTGAAAGACCAGAAGATTTAGTTGTTTATGGTGGTATTGGAAAAGCAGCACGTAATT
GGGAAGCTTTTGAAGCAATAGAGAAAACGTTACGAGAATTAGAATCAGATGAGACAATGTTAGTACAATCAGGAAAGCCA
GTTGCTGTATTTAAAACACATGAAGAAGCGCCACGTGTATTAATTTCAAATTCAGTATTAGTGCCTGAATGGGCAAACTG
GGATCATTTTAATGAATTAGATAAAAAAGGTTTAATCATGTATGGACAGATGACAGCCGGTAGTTGGATATATATTGGTT
CTCAAGGTATTGTGCAAGGTACTTATGAGACATTTGCCGAGCTAGGTAATCAACACTTTAATGGAGATTTAGCAGGCACT
GTTACACTGACAGCAGGTTTAGGTGGTATGGGTGGTGCGCAACCGTTAGCAATTACTATGAATCATGGGGTAGCAATTTG
CGTGGATGTTGATGAAACACGTGTTGATAAGCGAATTGATACGAAATACTGTGATGTTAAAACAGCTGATTTAGATGAAG
CATTAAAATTAGCAGAAGAGGCGAAAGAACGTGGAGAAGGATTATCAATCGGGTTAGTTGGAAATGCTGTAGACATCCAT
CAAGCGATTCTAGAAAAAGGATTTAAAATTGACATTATTACTGACCAAACAAGTGCACATGATCCGCTAAATGGATATGT
GCCACAAGGATACTCTGTAGAAGAAGCGAAAGTATTGCGTGAAAAAGATCCGAAAAAATATGTTGAACTGTCACAAGCTT
CAATGGCAAAGCATGTTGAATTAATGCTTGAATTCCAAAAACGTGGCGCTGTAGCATTTGATTATGGTAACAATATTCGT
CAAGTAGCCTTCAATAACGGAGTGAAAAATGCTTTTGACTTCCCAGGCTTTGTACCAGCTTACATTAGACCATTATTCTG
TGAAGGTAAAGGGCCATTCCGCTTTGCTGCGTTGAGTGGTGATCCAAAAGATATCGAGCGTGCGGATGAAGAAATGCGCA
AACTTTTCCCAGAAAATGAAAAGTTATTAAGATGGCTTGATTTAGCTGAAGAAAAAATTTCATATCAAGGACTACCATCA
CGTATTGCTTGGTTAGGCTATGGAGAAAGAGCGAAAATGGGCTTAGCTTTAAATCGTCTTGTACGTGACGGTGAAATTTC
AGCACCAATTGTTATTGGACGAGACCATTTAGATGCTGGTTCAGTTGCTAGTCCTAACCGTGAAACAGAAAGTATGAAAG
ATGGTAGTGACGCGGTTGGTGATTGGGCTGTATTGAATGCACTCATTAACACAGCTGCAGGTGGTTCATGGATTTCATTC
CATCACGGTGGCGGTGTTGGCATGGGATATTCACTTCATGCGGGTATGGTTGTTGTAGCAGATGGATCAGAGCGTGCTGA
AAGAAGATTGGAACGTGTATTGACGACTGACCCAGGTATGGGTGTTGCCCGACATGTTGATGCTGGCTATGACATCGCTA
TTCAAACAGCTAAAGAAAAAGGTATTCATATTCCAATGATTGATAAAGCAGGTGATAAGTAA

Upstream 100 bases:

>100_bases
TTGGCTATATTTTAACATACTATAATGAATATTGAAGATAATAATGTAAGCGTTTTAAATTTAGTGGAATTAACTTCTTA
AAAGAACAGGAGCGAATTTT

Downstream 100 bases:

>100_bases
TGAATGATTTAATAATTAATCATATAGCAGAATTAATTTTACCGAGATCAACAGATAAACCTTTGAAGGGTAAGGAATTA
GATGAATTAAATGTTGTGAA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK

Sequences:

>Translated_553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
>Mature_553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=559, Percent_Identity=33.4525939177102, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI260306182, Length=619, Percent_Identity=30.8562197092084, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71997891, Length=550, Percent_Identity=33.6363636363636, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_STAAC (Q5HDM6)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187131.1
- ProteinModelPortal:   Q5HDM6
- SMR:   Q5HDM6
- STRING:   Q5HDM6
- EnsemblBacteria:   EBSTAT00000009299
- GeneID:   3237922
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2324
- TIGR:   SACOL2324
- eggNOG:   COG2987
- GeneTree:   EBGT00050000024536
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   SAUR93062:SACOL2324-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60634; Mature: 60634

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHCCHHHHHHH
EKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIM
HHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCCCHHHHHCCCCEEE
YGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITM
EEEECCCCEEEECCCCCEECHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEE
NHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
CCCEEEEEECCHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVE
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSG
HHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEEECC
DPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRL
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
VRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEK
ECCCCCCCCEEECCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEHHHC
GIHIPMIDKAGDK
CCEEEECCCCCCC
>Mature Secondary Structure
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHCCHHHHHHH
EKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIM
HHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCCCHHHHHCCCCEEE
YGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITM
EEEECCCCEEEECCCCCEECHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEE
NHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
CCCEEEEEECCHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVE
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSG
HHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEEECC
DPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRL
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
VRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEK
ECCCCCCCCEEECCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEHHHC
GIHIPMIDKAGDK
CCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA