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The map label for this gene is tcmP [H]

Identifier: 57650695

GI number: 57650695

Start: 2069080

End: 2069925

Strand: Reverse

Name: tcmP [H]

Synonym: SACOL2009

Alternate gene names: 57650695

Gene position: 2069925-2069080 (Counterclockwise)

Preceding gene: 57650696

Following gene: 57650694

Centisome position: 73.68

GC content: 26.83

Gene sequence:

>846_bases
ATGAAGCAACTGGTTGGAATTCCCGAATCAATGTTAATTCCTTTGATAGCTCGAGCAAAAGAGTACGAAAACGAAAAACC
AATAATAAAAGACGCACTATCAAAAAAAATATTTGATGGTTTAGATGATATGTACAAAAATGTTACATGTGATGACATGT
CTCAAATTGGAATTAGTATACGTACTGTGATAATAGATTGTGTTACTAAGAGGCTTATCAAGGATAATAAAGATTTAATC
GTGGTCAATATAGGTTGTGGCTTAGATACAAGGTTTCAAAGATTTAATAAAGAAAAAATATCATGGATAGATTTAGATGT
ACCAGAATCAATAGAAATACGAAAAACATTTTTTAAAGAAAGTAATAGTTATAAGATGATATCTAAATCTATGCTAGATT
ACAGTTGGATTGATGATGTCAAAAATTATAAATTTTTTAATAGTAAGTCAGATATATTGTTTATTATTGAAGGTGTATTG
ATGTATTTTGATGAGAGTGTAATGACTCAATTATTGGACACTATTATCAAAAAGATGGGAGATCATAATTTGACATTTGC
GATTGAATTTTGCTCAAAAACAATTGCGAATAATACAAAGAGACATCAATCGGTATCAAAGTTATCCTCACAACCTGTTT
TTAAATATGGTTACAATGATTTAAAAAAATTGAATGAAATTTTACCAAATACAATAAGAGTAATACATGAATATAATTAT
TTTGACTATTATAAGAATCGATGGGGCTTATTTGGATATTGTAGATTTATACCTTATTTAAAAAAAAGGTTAAACAATAA
AATAGTACTTATGAAATATAAAGTTCCAAAGAGACAGAGACATTAA

Upstream 100 bases:

>100_bases
AGAAGTAAATTAAAAAAAGAAATTTTAAATAAAAAATAATAGAAATAAGTTGTAAAAATTTTCTTATGCATTGGTACTAA
TGTTTTTAAGGAGTGATTAA

Downstream 100 bases:

>100_bases
GTTCTTAGACAATGTAAAAAAGCTGATTTCTATAAATTATTTGATAGAAATCAGCTTTTTTCAAATGTATTTGATAATTT
ACAGCTCGTTGAGCTGCTGT

Product: tetracenomycin polyketide synthesis O-methyltransferase TcmP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISIRTVIIDCVTKRLIKDNKDLI
VVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKESNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVL
MYFDESVMTQLLDTIIKKMGDHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH

Sequences:

>Translated_281_residues
MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISIRTVIIDCVTKRLIKDNKDLI
VVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKESNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVL
MYFDESVMTQLLDTIIKKMGDHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
>Mature_281_residues
MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISIRTVIIDCVTKRLIKDNKDLI
VVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKESNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVL
MYFDESVMTQLLDTIIKKMGDHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 33223; Mature: 33223

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISI
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RTVIIDCVTKRLIKDNKDLIVVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKE
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHHC
SNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVLMYFDESVMTQLLDTIIKKMG
CCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
CCCEEEEHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHCCH
FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISI
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RTVIIDCVTKRLIKDNKDLIVVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKE
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHHC
SNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVLMYFDESVMTQLLDTIIKKMG
CCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
CCCEEEEHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHCCH
FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]