Definition Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession NC_002951
Length 2,809,422

Click here to switch to the map view.

The map label for this gene is pyk

Identifier: 57650568

GI number: 57650568

Start: 1781926

End: 1783683

Strand: Reverse

Name: pyk

Synonym: SACOL1745

Alternate gene names: 57650568

Gene position: 1783683-1781926 (Counterclockwise)

Preceding gene: 57650569

Following gene: 57650566

Centisome position: 63.49

GC content: 34.76

Gene sequence:

>1758_bases
ATGAGAAAAACTAAAATTGTATGTACAATTGGACCAGCTTCAGAATCAGAAGAAATGATTGAGAAATTAATCAATGCTGG
TATGAACGTTGCACGATTAAACTTTTCACATGGTAGTCATGAAGAGCATAAAGGTAGAATTGATACAATTCGTAAAGTAG
CTAAAAGATTAGACAAAATTGTAGCAATTTTATTAGATACAAAAGGTCCAGAAATTCGTACGCATAATATGAAAGACGGT
ATCATTGAACTTGAACGTGGCAACGAAGTTATTGTTAGCATGAATGAAGTTGAAGGAACACCTGAAAAGTTCTCAGTAAC
ATATGAAAACTTAATTAACGATGTTCAAGTAGGTTCATACATTTTACTTGATGATGGCTTAATTGAATTACAAGTTAAAG
ATATTGACCATGCTAAAAAAGAAGTTAAATGTGATATTTTAAACTCTGGTGAGCTTAAAAACAAAAAAGGTGTTAACTTA
CCTGGCGTAAGAGTAAGTTTACCTGGTATTACAGAAAAAGATGCTGAAGATATCCGTTTCGGTATTAAAGAAAATGTTGA
CTTCATTGCAGCAAGTTTCGTACGTCGTCCTAGTGATGTTTTAGAAATTCGTGAAATTTTAGAAGAACAAAAAGCTAACA
TTTCAGTATTCCCTAAAATTGAAAACCAAGAAGGTATTGATAATATTGCGGAAATTCTTGAAGTGTCTGATGGTTTAATG
GTTGCACGTGGTGACATGGGTGTTGAAATTCCACCTGAAAAAGTACCAATGGTTCAAAAAGATTTAATCAGACAATGTAA
CAAATTAGGTAAACCAGTTATTACAGCTACACAAATGTTAGATTCTATGCAACGTAACCCACGTGCTACACGTGCAGAAG
CTAGTGACGTTGCCAACGCAATCTATGATGGTACAGATGCAGTAATGTTATCTGGTGAAACTGCTGCTGGTTTATATCCT
GAAGAAGCTGTTAAAACAATGAGAAATATTGCTGTATCAGCTGAAGCAGCCCAAGATTACAAAAAGTTATTGTCAGATCG
TACTAAATTAGTTGAAACTTCATTAGTGAATGCTATCGGTATTTCGGTTGCACATACAGCTTTAAACTTAAATGTTAAAG
CAATTGTAGCTGCTACTGAAAGTGGTTCAACGGCACGTACTATCTCCAAATATCGTCCACATTCAGACATTATTGCGGTG
ACTCCAAGTGAAGAAACTGCACGTCAATGTTCAATTGTTTGGGGAGTTCAACCTGTAGTTAAAAAAGGACGTAAGAGTAC
AGATGCATTGTTAAACAATGCAGTTGCAACAGCTGTTGAAACTGGTAGAGTATCTAATGGTGATTTAATCATTATTACTG
CTGGTGTACCAACTGGTGAAACTGGAACTACTAATATGATGAAAATCCACCTAGTTGGTGACGAAATTGCTAATGGTCAA
GGTATTGGACGTGGATCAGTTGTTGGTACTACGTTAGTTGCTGAAACTGTTAAAGATTTAGAAGGTAAAGATTTATCTGA
CAAAGTTATCGTTACTAACTCAATCGATGAAACGTTTGTACCTTATGTAGAAAAAGCTTTAGGCTTAATTACAGAAGAAA
ATGGTATTACATCACCAAGTGCAATTGTTGGTTTAGAAAAAGGTATTCCAACAGTTGTAGGTGTAGAAAAAGCTGTTAAA
AACATAAGCAATAACATGTTAGTTACGATTGATGCTGCTCAAGGTAAAATCTTTGAAGGATATGCAAACGTACTATAA

Upstream 100 bases:

>100_bases
TTTTGATGAAATTTTTGATGGTAAAGATCATAAATTTGATTATAGTCTATATGAACTTGCTAACAAGTTATCTATATAAG
ATTTCAGGAGGAATTATAAA

Downstream 100 bases:

>100_bases
TTTATAAAAAAACGTCTTTCCATTTATCAACAATGGAAAGGCGTTTTTTGGTTCATCTGGTATTTTATGACGTAATTAAT
AGGTTATTTGATAATGATAG

Product: pyruvate kinase

Products: NA

Alternate protein names: PK

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDG
IIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNL
PGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLM
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYP
EEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAV
TPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVK
NISNNMLVTIDAAQGKIFEGYANVL

Sequences:

>Translated_585_residues
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDG
IIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNL
PGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLM
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYP
EEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAV
TPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVK
NISNNMLVTIDAAQGKIFEGYANVL
>Mature_585_residues
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDG
IIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNL
PGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLM
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYP
EEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAV
TPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVK
NISNNMLVTIDAAQGKIFEGYANVL

Specific function: Glycolysis; final step. [C]

COG id: COG0469

COG function: function code G; Pyruvate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PEP- utilizing enzyme family

Homologues:

Organism=Homo sapiens, GI33286422, Length=490, Percent_Identity=45.1020408163265, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI33286420, Length=490, Percent_Identity=45.1020408163265, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI33286418, Length=490, Percent_Identity=44.4897959183673, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI10835121, Length=492, Percent_Identity=44.1056910569106, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI32967597, Length=492, Percent_Identity=44.1056910569106, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI310128732, Length=291, Percent_Identity=48.4536082474227, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI310128730, Length=291, Percent_Identity=48.4536082474227, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI310128736, Length=239, Percent_Identity=45.6066945606695, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI310128734, Length=239, Percent_Identity=45.6066945606695, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI310128738, Length=218, Percent_Identity=44.4954128440367, Blast_Score=168, Evalue=2e-41,
Organism=Escherichia coli, GI1787965, Length=478, Percent_Identity=48.5355648535565, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1788160, Length=475, Percent_Identity=39.3684210526316, Blast_Score=297, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17544584, Length=485, Percent_Identity=45.979381443299, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71984413, Length=485, Percent_Identity=43.5051546391753, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71984406, Length=485, Percent_Identity=43.5051546391753, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17506829, Length=485, Percent_Identity=43.5051546391753, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17506831, Length=485, Percent_Identity=43.5051546391753, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319279, Length=485, Percent_Identity=42.680412371134, Blast_Score=346, Evalue=5e-96,
Organism=Saccharomyces cerevisiae, GI6324923, Length=490, Percent_Identity=41.0204081632653, Blast_Score=327, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24648964, Length=488, Percent_Identity=44.8770491803279, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI28571814, Length=488, Percent_Identity=44.8770491803279, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24648966, Length=409, Percent_Identity=44.4987775061125, Blast_Score=321, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24581235, Length=486, Percent_Identity=36.4197530864198, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24646914, Length=270, Percent_Identity=40.3703703703704, Blast_Score=191, Evalue=1e-48,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 124 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KPYK_STAA3 (Q2FG40)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494338.1
- HSSP:   P11974
- ProteinModelPortal:   Q2FG40
- SMR:   Q2FG40
- STRING:   Q2FG40
- EnsemblBacteria:   EBSTAT00000038167
- GeneID:   3914281
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1644
- eggNOG:   COG0469
- GeneTree:   EBGT00050000025037
- HOGENOM:   HBG734376
- OMA:   TAHNVSK
- ProtClustDB:   CLSK885504
- GO:   GO:0006096
- InterPro:   IPR008279
- InterPro:   IPR001697
- InterPro:   IPR015813
- InterPro:   IPR011037
- InterPro:   IPR015794
- InterPro:   IPR015793
- InterPro:   IPR015795
- InterPro:   IPR015806
- Gene3D:   G3DSA:3.50.30.10
- Gene3D:   G3DSA:2.40.33.10
- Gene3D:   G3DSA:3.20.20.60
- Gene3D:   G3DSA:3.40.1380.20
- PANTHER:   PTHR11817
- PRINTS:   PR01050
- TIGRFAMs:   TIGR01064

Pfam domain/function: PF00391 PEP-utilizers; PF00224 PK; PF02887 PK_C; SSF52009 PEP_mobile; SSF50800 PK_B_barrel_like; SSF52935 Pyruvate_kinase; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.7.1.40

Molecular weight: Translated: 63103; Mature: 63103

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00110 PYRUVATE_KINASE

Important sites: BINDING 32-32 BINDING 244-244 BINDING 245-245 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKI
CCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHCCHHHHHHHHHHHHHHH
VAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSY
HHHEECCCCCCEEECCCCCCEEEEECCCEEEEEECCCCCCCHHEEEEHHHHHCHHCCCCE
ILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRF
EEEECCEEEEEECCCHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHH
GIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLM
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCEE
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANA
EEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIG
HHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVV
HHHHHHEEECEEEEEEEECCCCCHHHHHHHCCCCCCEEEECCCHHHHHHEEEEECCCHHH
KKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
HCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCC
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPS
CCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHEECCCCCCCCH
AIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
HHEEHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHCC
>Mature Secondary Structure
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKI
CCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHCCHHHHHHHHHHHHHHH
VAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSY
HHHEECCCCCCEEECCCCCCEEEEECCCEEEEEECCCCCCCHHEEEEHHHHHCHHCCCCE
ILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRF
EEEECCEEEEEECCCHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHH
GIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLM
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCEE
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANA
EEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIG
HHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVV
HHHHHHEEECEEEEEEEECCCCCHHHHHHHCCCCCCEEEECCCHHHHHHEEEEECCCHHH
KKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
HCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCC
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPS
CCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHEECCCCCCCCH
AIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
HHEEHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA