Definition Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession NC_002951
Length 2,809,422

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The map label for this gene is cycA [H]

Identifier: 57650567

GI number: 57650567

Start: 1778240

End: 1779601

Strand: Direct

Name: cycA [H]

Synonym: SACOL1743

Alternate gene names: 57650567

Gene position: 1778240-1779601 (Clockwise)

Preceding gene: 57650537

Following gene: 57652004

Centisome position: 63.3

GC content: 34.88

Gene sequence:

>1362_bases
ATGGCTGAAAAATTACAAAGGGAACTGAGCAATCGCCACATACAATTAATTGCAATTGGCGGTGCAATTGGTACAGGCTT
ATTCTTAGGTGCTGGTCAAACGATTGCATTAACCGGCCCTTCAATTCTATTAACATACATCATTATAGGATTTATGTTAT
TTATGTTTATGCGAGGTTTAGGAGAAATCATTATACAGAATACTGAATTTAAATCTTTCGCAGATGTAACCAATACATAT
ATTGGGCCTTTTGCAGGATTTGTTACCGGATGGACATACTGGTTCTGTTGGATTATTACAGGTATGGCTGAAGTAACGGC
TGTGGCAAAATATGTTAGCTTTTGGTTCCCAGAAATTCCAAACTGGATAAGTGCACTATTTTGTGTACTGTTATTAATGT
CATTCAACCTACTTAGCGCAAGACTTTTCGGAGAATTAGAATTTTGGTTCTCTATCATTAAAATAGCGACAATTATTGGT
TTAATAGTAGTTGGTTTCGTCATGATTCTATTTGCATTTAAAACTCAATTCGGGCATGCCAGTTTCACAAATCTATATGA
ACACGGCATATTCGCTAAAGGTGCTTCTGGATTCTTTATGTCTTTCCAAATGGCACTATTCTCATTTGTAGGAATTGAAA
TGATTGGTGTTACAGCTGGGGAAACAAAAGATCCAGTTAAAACAATTCCAAAAGCAATTAACAGTGTACCCATTAGAATT
TTAATATTTTACGTTGGGGCGTTAGCGGTTATCATGTCTATTATCCCTTGGCAGCAAGTTGATCCTGATAACAGTCCATT
CGTAAAATTATTCGCATTGATCGGAATTCCGTTTGCTGCGGGCTTGATTAATTTTGTAGTATTAACCGCTGCTGCTTCAT
CATGTAACAGTGGTATATTCTCAAATAGCCGTATGCTTTTCGGTTTATCAAGTCAACAACAAGCACCTCCGAACTTTTCT
AAGACGAATAAATATGGCGTTCCACATGTTGCAATCTTTGCTTCATCAGCATTATTACTTGTGGCAGCATTACTAAACTA
TATTTTCCCAGATGCGACAAAAGTATTTACGTATGTGACTACCATCTCTACAGTGTTATTTTTAGTTGTATGGGGTCTGA
TTATCATTGCATATATCAATTATAGTCGTAAAAACCCAGATCTACATAAAAATGCTACGTACAAACTATTAGGTGGCAAA
TATATGGGCTACTTAATATTTGTATTCTTCATTTTTGTGTTCGGGTTATTATTTATTAATGTTGATACAAGACGTGCAAT
TTATTTTATTCCGATTTGGTTTATACTTTTAGCATTTATGTACTTAAGATATAAACGTATCGCTGCTAAATCAAATAAAT
AA

Upstream 100 bases:

>100_bases
GTATATTAACATGGAATTTTACACATTTTTACCGAAAATAATTGTATATATCTCAATATAAGTGCATAATAAACATATCT
ATATTTAAGGGAGATGTATT

Downstream 100 bases:

>100_bases
CAACAAGTTTTAGGGCTTGGGACATTAAGTTCTTAGGCAATGTAAAAAAGCTGATTTCTATTAATTATTTGATAGAAATC
AGCTTTTTTGATATGTATTT

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTY
IGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIG
LIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRI
LIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFS
KTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGK
YMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK

Sequences:

>Translated_453_residues
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTY
IGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIG
LIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRI
LIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFS
KTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGK
YMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
>Mature_452_residues
AEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYI
GPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGL
IVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRIL
IFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSK
TNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKY
MGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=285, Percent_Identity=22.8070175438596, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=51.9823788546256, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI48994972, Length=434, Percent_Identity=44.2396313364055, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=44.1758241758242, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=39.8678414096916, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=40.5405405405405, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=34.7290640394089, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87081708, Length=401, Percent_Identity=34.9127182044888, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788480, Length=395, Percent_Identity=38.4810126582278, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1789017, Length=419, Percent_Identity=30.5489260143198, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI2367353, Length=320, Percent_Identity=26.5625, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532491, Length=373, Percent_Identity=23.0563002680965, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=398, Percent_Identity=33.9195979899498, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=469, Percent_Identity=31.5565031982942, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324061, Length=399, Percent_Identity=30.3258145363409, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=440, Percent_Identity=29.7727272727273, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=389, Percent_Identity=32.9048843187661, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=399, Percent_Identity=31.8295739348371, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6324059, Length=455, Percent_Identity=29.010989010989, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=399, Percent_Identity=28.5714285714286, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=427, Percent_Identity=27.6346604215457, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=381, Percent_Identity=28.3464566929134, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=407, Percent_Identity=25.7985257985258, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319824, Length=403, Percent_Identity=26.5508684863524, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=434, Percent_Identity=26.036866359447, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=24.317617866005, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=425, Percent_Identity=28.4705882352941, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=24.1813602015113, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320251, Length=396, Percent_Identity=23.4848484848485, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=449, Percent_Identity=24.9443207126949, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50482; Mature: 50351

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGL
CCHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
GEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIP
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCCHHHH
LIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIF
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVT
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFIN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHC
VDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGL
CHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
GEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIP
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCCHHHH
LIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIF
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVT
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFIN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHC
VDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]