BacMap

Definition	Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession	NC_002951
Length	2,809,422

Click here to switch to the map view.

The map label for this gene is icd

Identifier: 57650565

GI number: 57650565

Start: 1775454

End: 1776722

Strand: Reverse

Name: icd

Synonym: SACOL1741

Alternate gene names: 57650565

Gene position: 1776722-1775454 (Counterclockwise)

Preceding gene: 57650566

Following gene: 57650564

Centisome position: 63.24

GC content: 34.99

Gene sequence:

>1269_bases
ATGACTGCAGAAAAAATTACTCAAGGAACTGAAGGATTAAACGTACCTAATGAACCAATTATCCCATTTATTATCGGTGA
TGGAATTGGACCGGATATTTGGAAGGCAGCAAGCCGAGTTATAGATGCTGCTGTTGAGAAAGCCTATAATGGCGAAAAAC
GCATTGAATGGAAAGAAGTGCTAGCTGGCCAAAAAGCATTTGATACAACTGGTGAATGGTTACCTCAAGAAACACTTGAT
ACAATTAAAGAATATTTAATTGCTGTTAAAGGACCTTTAACAACACCAATTGGTGGTGGTATTAGATCATTAAATGTGGC
TTTACGCCAAGAATTAGATTTATTTACTTGCTTAAGACCGGTACGTTGGTTTAAAGGAGTACCATCACCTGTTAAACGTC
CACAAGATGTTGATATGGTTATTTTCCGTGAAAATACTGAAGACATTTATGCTGGTATTGAATTTAAAGAAGGTACAACA
GAAGTTAAAAAGGTAATTGACTTCTTACAAAACGAAATGGGTGCGACAAACATTCGATTCCCAGAAACTTCAGGTATTGG
TATTAAACCAGTTTCTAAAGAAGGAACTGAGCGATTAGTTAGAGCAGCTATACAATATGCTATCGATAATAACCGTAAAT
CAGTTACTTTAGTTCATAAAGGTAATATTATGAAATTTACAGAAGGCTCATTTAAGCAGTGGGGTTACGATTTAGCATTA
TCTGAATTTGGTGATCAAGTATTCACTTGGCAACAATATGACGAAATTGTTGAAAATGAAGGCAGAGATGCTGCTAATGC
TGCTCAAGAAAAAGCTGAAAAAGAAGGCAAGATTATCATTAAAGATTCTATTGCTGACATTTTCTTACAACAAATTTTAA
CTCGTCCAGCTGAGCATGATGTTGTAGCAACTATGAACTTGAATGGTGACTATATTTCAGATGCTTTAGCTGCACAAGTT
GGTGGTATTGGTATTGCGCCAGGTGCAAACATTAATTATGAAACAGGTCATGCTATTTTTGAAGCAACACATGGTACAGC
TCCAAAATATGCAGGTTTAAATAAAGTGAATCCATCTTCAGTAATTTTAAGTTCTGTATTAATGTTAGAACATTTAGGAT
GGCAAGAAGCGGCAGATAAGATTACAGATTCAATTGAAGATACAATTGCTTCAAAAGTTGTTACTTATGACTTTGCCCGT
TTAATGGATGGTGCTGAAGAAGTTTCTACATCAGCATTTGCAGATGAATTGATTAAAAATTTAAAATAA

Upstream 100 bases:

>100_bases
ATATATTGGCGAAACGAATCGTAAGTATATCCCGCTTGAAGAAAGAAAATAATCAATACAAATTAAAAATGAAGATGTAA
AATTTGGAGGTAAAATAACT

Downstream 100 bases:

>100_bases
GCAAAATAAAATTAGGTGAGTCTAGCAACTTTAATTGCTAGGTTCGCCTTTTTAAATGAATTGAAGTTGGCAACAGGATA
GAAATAATAAAGAGTCACCA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD
TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTT
EVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
SEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV
GGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFAR
LMDGAEEVSTSAFADELIKNLK

Sequences:

>Translated_422_residues
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD
TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTT
EVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
SEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV
GGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFAR
LMDGAEEVSTSAFADELIKNLK
>Mature_421_residues
TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDT
IKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTE
VKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALS
EFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVG
GIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARL
MDGAEEVSTSAFADELIKNLK

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

Homologues:

Organism=Homo sapiens, GI5031777, Length=413, Percent_Identity=31.4769975786925, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI28178816, Length=368, Percent_Identity=27.7173913043478, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI28178821, Length=368, Percent_Identity=27.7173913043478, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4758582, Length=368, Percent_Identity=27.7173913043478, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI28178838, Length=368, Percent_Identity=27.7173913043478, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=30.1507537688442, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1787381, Length=422, Percent_Identity=62.7962085308057, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI1788101, Length=413, Percent_Identity=30.7506053268765, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI87081683, Length=411, Percent_Identity=27.2506082725061, Blast_Score=101, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=371, Percent_Identity=30.9973045822102, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=378, Percent_Identity=30.4232804232804, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17505779, Length=362, Percent_Identity=29.0055248618785, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324709, Length=404, Percent_Identity=31.4356435643564, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322097, Length=376, Percent_Identity=30.8510638297872, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6324291, Length=403, Percent_Identity=29.0322580645161, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24643268, Length=402, Percent_Identity=32.3383084577114, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24643270, Length=409, Percent_Identity=32.518337408313, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24661184, Length=403, Percent_Identity=31.7617866004963, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161078635, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161078633, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24650122, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161078637, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161078639, Length=320, Percent_Identity=30.3125, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI281362242, Length=413, Percent_Identity=25.6658595641646, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648872, Length=413, Percent_Identity=25.6658595641646, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IDH_STAAC (Q5HF79)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186578.1
- ProteinModelPortal:   Q5HF79
- SMR:   Q5HF79
- STRING:   Q5HF79
- EnsemblBacteria:   EBSTAT00000010752
- GeneID:   3236289
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1741
- TIGR:   SACOL1741
- eggNOG:   COG0538
- GeneTree:   EBGT00050000023966
- HOGENOM:   HBG518924
- OMA:   RDWGYEL
- ProtClustDB:   PRK07006
- BioCyc:   SAUR93062:SACOL1741-MONOMER
- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439
- Gene3D:   G3DSA:3.40.718.10
- PANTHER:   PTHR11835
- PANTHER:   PTHR11835:SF1
- TIGRFAMs:   TIGR00183

Pfam domain/function: PF00180 Iso_dh

EC number: =1.1.1.42

Molecular weight: Translated: 46423; Mature: 46292

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00470 IDH_IMDH

Important sites: BINDING 94-94 BINDING 103-103 BINDING 105-105 BINDING 109-109 BINDING 119-119 BINDING 143-143 BINDING 357-357 BINDING 396-396 BINDING 400-400

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEV
CCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF
HHHHCCCCCHHCCCCCCCEEEEECCCCHHEECCEECCCHHHHHHHHHHHHHHCCCCCCCC
PETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHCHHHHH
SEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD
HHHCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCC
VVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSS
EEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHH
VILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LK
CC
>Mature Secondary Structure 
TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEV
CHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF
HHHHCCCCCHHCCCCCCCEEEEECCCCHHEECCEECCCHHHHHHHHHHHHHHCCCCCCCC
PETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHCHHHHH
SEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD
HHHCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCC
VVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSS
EEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHH
VILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA