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The map label for this gene is phoR [H]

Identifier: 57650563

GI number: 57650563

Start: 1772699

End: 1774363

Strand: Reverse

Name: phoR [H]

Synonym: SACOL1739

Alternate gene names: 57650563

Gene position: 1774363-1772699 (Counterclockwise)

Preceding gene: 57650564

Following gene: 57650562

Centisome position: 63.16

GC content: 31.05

Gene sequence:

>1665_bases
ATGATGAAGTTTCACCACCGCTTAATGTTATTGATAAGCAGTATATTAATTATCAGTTTTGTTACATTAGGCATTATTAT
TCACGCTTCCATCACATATGTTTTATCAGAAAAACACGAACAAGCTCTAGCAACAGATGCAAGATCATATATTTATTTAG
TCCAAGATAATGAGATTGATAAAGTTAAAAAAATTGTAAAACAGCAAAATATAGATTTATTGATAACTAAGCATGATAAA
AAGGTGTTTAGTAGTGGCAAACTGAAAGCTATCCCAAATAGTGATAGCTATATTCAAAAAAGGGACGTTTTTATTTTTAA
TAAGAAGGTTAACGGTTATCATGTATGGATTAAAGGTTACAATAACGATATTACAGAAATGCATTGGACGTTGTGGAAAT
ATCTTATTTTGACATGTTTAGTTGTACTCATTTGTCTGTATTTTGCAAGCCGTAGTTTTAAGCGTACATTAATCCGTCCC
ATTCAAGAAGTTACTTATGCAACACAATTGTTGGCAAATGGTTATTATCACATACGTGTACCTGAAAGTAATGTTGTAGA
AACTAAAGCGCTTTTTGTGTCTACCAATGATTTAGCACGACGCCTTCAAAAGCTTAATAATGAGCAAAAAATTCAATCCA
ACCGTTTAAAAACAACGATTGAAAATATTCCAAGTGCTATTTTAATGATAGATCGAAATGGAAAAATCGTTGTTGCAAAT
AAAGCGTATTATGAACAGTTCAACATCTCGCATAATATTGAACAAGTAGGCTATCACGGCTATGTTAATACTGAAATTGA
GCAATTAATTTTAGAAAGTTTTAAAGTTGAAAAACCTATTTATGAACAATTGGAAGTTGCAATAAACCAAGTCCATGCCA
AGTACTTTGATATTTCATGCGTTCCGATTTTAACTAGGTCTCAAAAAAGTTTGCAAGGGATTTTAGTTGTGATGCATGAT
ATAACAAATCTGAAACAACTTGAAAATCTAAGACGTGAATTTGTAGCAAATGTTTCACATGAATTAAAAACACCTATTAC
TTCAATTAAGGGGTTTGCTGAAACGCTTATTGATGGTGCAAAAAATGATGCGGAATCATTAGACATGTTTTTAAACATAA
TTTTAAAAGAATCAAATCGAATAGAATCTTTAGTAACAGATCTGTTAGATTTATCGCATATTGAGCAACATACAGAGTTA
GATACAGACTATATGAATTTATCAGATTTAACGCGGCGTATTATTGATAATATGATGACTCAAGCCAATCAAAAAAATAT
TTCCATTCATACTGATATTGAAAAAGATGTCATTGTTAAAGCACAAGAAAGTAAAATTGCTCAAGTTATCACGAATTTGT
TAACGAATGCAATTAACTATTCTTATGAAGATGGAGATATTAACGTTCGTGTGTATCGAGATGACTTTCGTGTCATTTTC
GAAGTACAAGATTTTGGTATAGGTATTAAATTAGAAGACCAACAACGTATTTTTGAAAGATTTTATAGAGTAGATAAAGC
ACGAAGTAGAGATTCTGGTGGGACAGGTCTTGGATTATCAATTACAAAGCATATAGTAGAGGCCCACCAAGGCAATATTG
AAGTGAATAGTCAAGTTGGCAAAGGCTCAACGTTCAAAGTTATTCTAAAAGATTATAAAGAATAA

Upstream 100 bases:

>100_bases
TCAGTCATTTAAGAGATAAATTAGAAGATAATCCTAAGAAGCCACAACTTATTAAAACTGTGCGTGGCTTAGGCTATAAA
TTGGAAAGACCTAAAGAACA

Downstream 100 bases:

>100_bases
AAATTAAAGTGGTAACAGCGCGTGTATTTTTCACGAAGTTGTTGCTGCTTTTTTATTTCGTTCAAATCTCTATTGGTATT
AAATTAGAGTTAATGAAGTG

Product: sensory box histidine kinase PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MMKFHHRLMLLISSILIISFVTLGIIIHASITYVLSEKHEQALATDARSYIYLVQDNEIDKVKKIVKQQNIDLLITKHDK
KVFSSGKLKAIPNSDSYIQKRDVFIFNKKVNGYHVWIKGYNNDITEMHWTLWKYLILTCLVVLICLYFASRSFKRTLIRP
IQEVTYATQLLANGYYHIRVPESNVVETKALFVSTNDLARRLQKLNNEQKIQSNRLKTTIENIPSAILMIDRNGKIVVAN
KAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISCVPILTRSQKSLQGILVVMHD
ITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTEL
DTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIF
EVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVILKDYKE

Sequences:

>Translated_554_residues
MMKFHHRLMLLISSILIISFVTLGIIIHASITYVLSEKHEQALATDARSYIYLVQDNEIDKVKKIVKQQNIDLLITKHDK
KVFSSGKLKAIPNSDSYIQKRDVFIFNKKVNGYHVWIKGYNNDITEMHWTLWKYLILTCLVVLICLYFASRSFKRTLIRP
IQEVTYATQLLANGYYHIRVPESNVVETKALFVSTNDLARRLQKLNNEQKIQSNRLKTTIENIPSAILMIDRNGKIVVAN
KAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISCVPILTRSQKSLQGILVVMHD
ITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTEL
DTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIF
EVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVILKDYKE
>Mature_554_residues
MMKFHHRLMLLISSILIISFVTLGIIIHASITYVLSEKHEQALATDARSYIYLVQDNEIDKVKKIVKQQNIDLLITKHDK
KVFSSGKLKAIPNSDSYIQKRDVFIFNKKVNGYHVWIKGYNNDITEMHWTLWKYLILTCLVVLICLYFASRSFKRTLIRP
IQEVTYATQLLANGYYHIRVPESNVVETKALFVSTNDLARRLQKLNNEQKIQSNRLKTTIENIPSAILMIDRNGKIVVAN
KAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISCVPILTRSQKSLQGILVVMHD
ITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTEL
DTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIF
EVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVILKDYKE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=35.9848484848485, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=33.7719298245614, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788549, Length=464, Percent_Identity=24.1379310344828, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=27.3504273504274, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=29.1512915129151, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI48994928, Length=268, Percent_Identity=29.4776119402985, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790861, Length=209, Percent_Identity=32.0574162679426, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=29.5833333333333, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788393, Length=216, Percent_Identity=28.2407407407407, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=30.7339449541284, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=27.6315789473684, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=28.8793103448276, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=217, Percent_Identity=30.8755760368664, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=27.8969957081545, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=25.3275109170306, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=23.8938053097345, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=222, Percent_Identity=25.2252252252252, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=224, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63906; Mature: 63906

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFHHRLMLLISSILIISFVTLGIIIHASITYVLSEKHEQALATDARSYIYLVQDNEID
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHH
KVKKIVKQQNIDLLITKHDKKVFSSGKLKAIPNSDSYIQKRDVFIFNKKVNGYHVWIKGY
HHHHHHHHCCCCEEEEECCHHHHCCCCEEECCCCCCCCEECCEEEEEEECCEEEEEEEEC
NNDITEMHWTLWKYLILTCLVVLICLYFASRSFKRTLIRPIQEVTYATQLLANGYYHIRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PESNVVETKALFVSTNDLARRLQKLNNEQKIQSNRLKTTIENIPSAILMIDRNGKIVVAN
CCCCCEEEEEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEE
KAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISC
HHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEE
VPILTRSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
KNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTELDTDYMNLSDLTRRIIDNMMT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
QANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIF
HCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCEEEEE
EVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVG
EEEECCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCC
KGSTFKVILKDYKE
CCCEEEEHHHHCCC
>Mature Secondary Structure
MMKFHHRLMLLISSILIISFVTLGIIIHASITYVLSEKHEQALATDARSYIYLVQDNEID
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHH
KVKKIVKQQNIDLLITKHDKKVFSSGKLKAIPNSDSYIQKRDVFIFNKKVNGYHVWIKGY
HHHHHHHHCCCCEEEEECCHHHHCCCCEEECCCCCCCCEECCEEEEEEECCEEEEEEEEC
NNDITEMHWTLWKYLILTCLVVLICLYFASRSFKRTLIRPIQEVTYATQLLANGYYHIRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PESNVVETKALFVSTNDLARRLQKLNNEQKIQSNRLKTTIENIPSAILMIDRNGKIVVAN
CCCCCEEEEEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEE
KAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISC
HHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEE
VPILTRSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
KNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTELDTDYMNLSDLTRRIIDNMMT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
QANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIF
HCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCEEEEE
EVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVG
EEEECCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCC
KGSTFKVILKDYKE
CCCEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]