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The map label for this gene is trpE [H]

Identifier: 57650371

GI number: 57650371

Start: 1414210

End: 1415616

Strand: Direct

Name: trpE [H]

Synonym: SACOL1403

Alternate gene names: 57650371

Gene position: 1414210-1415616 (Clockwise)

Preceding gene: 57650370

Following gene: 57650372

Centisome position: 50.34

GC content: 31.7

Gene sequence:

>1407_bases
ATGGATATATTTTATAAAAAAATAAAAGCAAATGTAACGCCCGAAGTTTTAGCACAACTTCATTCCAAGAAGATCATTTT
GGAAAGTACAAATCAACAACAAACTAAAGGTCGCTATTCAGTTGTTATTTTTGATATTTATGGCACTTTAACTTTAGATA
ATGATGTATTATCAGTAAGTACTTTAAAAGAATCGTATCAAATCACTGAAAGACCGTACCATTATTTAACGACTAAAATA
AATGAAGACTACCATAATATTCAAGATGAGCAACTTAAGTCATTACCATTTATATCTGGATATGTTGGGACGTGTAGCTT
TGATTTAGTAAGACATGAATTTCCTAAATTGCAATCAATACAATTAGAAGATCACAAGCAGCACGATGTAAGGTTATATA
TGGTTGAACAAGTTTATGTATTTGACCATTACAAAGATGAGTTATATATCATCGCGACGAATCAATTTTCAAATTCAACA
AAATCAGATCTTGAGAATCGAGTTATTAAGTCTATCGAAGACTTAACTAAAATCCAACCATTCATGCCTACACAAGATTT
TGATTTTAAAACTAAAGAAATTCAATCAAACATTTCTGAAGAAAGATTTATCGAAATGATTCAGTATTTCAAAGAGAAAA
TAACAGAAGGGGATATGTTCCAAGTTGTGCCATCAAGAATTTACAAATATGCGCATCATGCTAGTCAGCATTTAAATCAA
CTTTCGTTTCAACTGTATCAAAATTTAAAACGACAAAACCCAAGTCCATATATGTATTATCTTAATATCGATCAACCATA
TATTGTCGGTAGTTCTCCCGAAAGTTTCGTAAGTGTCAAAGATCAAATTGTAACAACTAATCCTATTGCAGGTACGATTC
AACGTGGTGAGACGACACAAATAGATAATGAGAATATGAAACAACTACTTAATGATCCAAAAGAATGCAGCGAACATCGT
ATGCTAGTTGATTTAGGACGTAATGATATTCATAGAGTAAGTAAAATCGGTACCTCAAAAATTACTAAATTAATGGTTAT
TGAAAAATATGAACATGTTATGCATATCGTAAGTGAAGTCACAGGTAAAATAAATCAAAATTTATCGCCAATGACAGTTA
TTGCGAATTTATTACCAACAGGTACCGTTTCAGGTGCACCAAAATTACGTGCAATTGAAAGAATATATGAACAATATCCA
CATAAACGGGGCGTTTATAGTGGTGGTGTTGGATACATAAATTGTAATCATAACTTAGATTTTGCATTAGCAATTCGAAC
GATGATGATAGATGAGCAGTATATCAACGTAGAAGCTGGTTGTGGCGTTGTATATGATTCTATTCCTGAAAAAGAACTGA
ATGAAACGAAATTGAAAGCTAAAAGCTTATTGGAGGTGAGCCCATGA

Upstream 100 bases:

>100_bases
TATGAATATTTCGAATATTCGGTTAATTTAGGTGGTACCACGCGTCAGCGTCCTTTATATTGATAAGGATGCTGGCGCTT
TTTTGAAAGGAGCGTATAGA

Downstream 100 bases:

>100_bases
TCTTAGTTGTAGATAATTATGATTCCTTTACATATAACCTAGTGGATATTGTTGCTCAACATACTGACGTCATTGTTCAA
TACCCTGATGATGATAATGT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKI
NEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNST
KSDLENRVIKSIEDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQ
LSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHR
MLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYP
HKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP

Sequences:

>Translated_468_residues
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKI
NEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNST
KSDLENRVIKSIEDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQ
LSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHR
MLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYP
HKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP
>Mature_468_residues
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKI
NEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNST
KSDLENRVIKSIEDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQ
LSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHR
MLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYP
HKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=377, Percent_Identity=32.3607427055703, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788114, Length=441, Percent_Identity=28.7981859410431, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786809, Length=224, Percent_Identity=26.7857142857143, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082077, Length=358, Percent_Identity=22.6256983240223, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=377, Percent_Identity=33.9522546419098, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324361, Length=416, Percent_Identity=22.8365384615385, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54111; Mature: 54111

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVS
CCCHHHHHHCCCCHHHHHHHHCCEEEEECCCCHHHCCCEEEEEEEEEEEEEECCCEEEHH
TLKESYQITERPYHYLTTKINEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSI
HHHHHHHHHCCCCEEEEEEECCHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCE
QLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNSTKSDLENRVIKSIEDLTKIQP
ECCCCCCCCEEEEEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
FMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQ
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHHEEECCCCCCCEECCCCCC
IDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEV
CCCHHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLD
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
FALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP
HHHHHHHHHHHHHHEEEECCCCEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVS
CCCHHHHHHCCCCHHHHHHHHCCEEEEECCCCHHHCCCEEEEEEEEEEEEEECCCEEEHH
TLKESYQITERPYHYLTTKINEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSI
HHHHHHHHHCCCCEEEEEEECCHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCE
QLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNSTKSDLENRVIKSIEDLTKIQP
ECCCCCCCCEEEEEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
FMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQ
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHHEEECCCCCCCEECCCCCC
IDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEV
CCCHHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLD
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
FALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP
HHHHHHHHHHHHHHEEEECCCCEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400208; 11337471 [H]