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The map label for this gene is thrB [H]

Identifier: 57650333

GI number: 57650333

Start: 1369542

End: 1370456

Strand: Direct

Name: thrB [H]

Synonym: SACOL1364

Alternate gene names: 57650333

Gene position: 1369542-1370456 (Clockwise)

Preceding gene: 57650332

Following gene: 57650334

Centisome position: 48.75

GC content: 35.96

Gene sequence:

>915_bases
ATGTCGAATGTTTTGGAGTTAACAATTCCTGCATCAACAGCCAACCTTGGAGTTGGCTTTGATTCTATAGGTATGGCTTT
AGATAAATTTTTGCATCTGTCTGTAAAGGAAACATCAGGGACAAAATGGGAATATATTTTCCATGATGATGCATCTAAGC
AATTGCCTACTGACGAAACAAACTTTATTTATCATGTAGCACAACAAGTTGCTTCTAAATATAGTGTTGACTTGCCTAAT
TTATGTATCGAAATGAGAAGTGATATTCCATTGGCAAGAGGGTTAGGTTCGTCAGCTTCTGCTTTAGTAGGAGCTATATA
TATCGCAAATTATTTTGGTGATATCCAACTGTCTAAACATGAGGTATTACAATTAGCGACTGAAATCGAAGGACATCCTG
ATAATGTTGCGCCGACCATTTATGGTGGTTTAATCGCTGGATATTATAATGATGTCTCGAAAGAAACGTCAGTTGCACAT
ATCGACATACCAGACGTGGATGTGATTGTAACGATACCAACTTATGAACTAAAAACAGAAGCATCAAGACGTGCTTTACC
ACAAAAATTAACACATAGTGAAGCGGTTAAAAGTAGTGCAATTAGTAATACAATGATTTGTGCATTAGCACAGCACAATT
ATGAATTAGCAGGTAAACTCATGCAACAAGATGGCTTTCATGAACCGTATCGTCAGCATTTAATTGCTGAATTTGATGAA
GTGAAAACAATTGCTAGTCAACATAATGCCTATGCAACTGTAATTAGTGGTGCTGGACCAACTATTTTAATATTTAGTCG
TAAAGAAAATAGTGGGGAATTGGTTCGCTCTTTAAATAGTCAGGTAGTATCATGCCATTCTGAATTGGTCGATATTAATA
TCAGTGGTGTTAAAGAACGAATTGTATACCAATAG

Upstream 100 bases:

>100_bases
AAAGATCCTGATACTGCTATTTCACTACTAGATAATCCGATAAAGCCATTGCCAAATGATAAAGATAGCATTATCGATTA
TATTAAAGGAGCTTTATAAC

Downstream 100 bases:

>100_bases
ACGCTTTATATTGTAAAATAGTATTAAATGCAGAATAGAGAGGAGATTTAATGCGATATGACAAATTATAAAGTTGTCGT
TTTAGATATGGATGACACAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPN
LCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETSVAH
IDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ

Sequences:

>Translated_304_residues
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPN
LCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETSVAH
IDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ
>Mature_303_residues
SNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPNL
CIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETSVAHI
DIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEV
KTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=290, Percent_Identity=26.8965517241379, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321814, Length=347, Percent_Identity=26.8011527377522, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33267; Mature: 33136

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDET
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCH
NFIYHVAQQVASKYSVDLPNLCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKH
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEECHH
EVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETSVAHIDIPDVDVIVTIPTYELKTE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCHHHCC
ASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
HHHHHHHHHHHHHHHHHHHHHCHHEEEEEHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKER
HHHHHHCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHH
IVYQ
HCCC
>Mature Secondary Structure 
SNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDET
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCH
NFIYHVAQQVASKYSVDLPNLCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKH
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEECHH
EVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETSVAHIDIPDVDVIVTIPTYELKTE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCHHHCC
ASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
HHHHHHHHHHHHHHHHHHHHHCHHEEEEEHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKER
HHHHHHCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHH
IVYQ
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA