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The map label for this gene is thrC [H]

Identifier: 57650332

GI number: 57650332

Start: 1368479

End: 1369540

Strand: Direct

Name: thrC [H]

Synonym: SACOL1363

Alternate gene names: 57650332

Gene position: 1368479-1369540 (Clockwise)

Preceding gene: 57650331

Following gene: 57650333

Centisome position: 48.71

GC content: 35.22

Gene sequence:

>1062_bases
ATGAGAAGATGGCAAGGATTAGTAGAAGAGTTTAAAGCACATTTACCAGTAAATGAAAATACACCAAAATTAACATTGAA
CGAGGGAAATACACCACTCATTCATTGTGAAAATATGTCTAAAATACTAGGCATAGATTTATATGTGAAGTATGAAGGTG
CCAATCCGACAGGTTCATTTAAAGATCGCGGTATGGTAATGGCTGTGACAAAAGCAAAAGAGCAAGGTAAGAAAATTGTA
ATATGCGCTTCGACTGGAAATACATCAGCGTCTGCAGCAGCATATGCAGCGAGAGCAGGTTTAAAAGCTATCGTCGTAAT
ACCAGAAGGTAAAATTGCATTAGGTAAATTGTCGCAAGCAGTAATGTATGGTGCAGAAATCGTTTCTATTGAAGGAAACT
TTGATGAAGCTTTAGAAATTGTAAAAGAAATTGCAAAAAGTGGCGAAATCGAGCTTGTAAACTCTGTCAATCCATTTAGA
ATCGAAGGACAAAAGACAGGCTCATTTGAAATTGTACAACAATTAGACGGTGAAGCACCTGATATTTTAGCGATTCCTGT
AGGTAATGCAGGTAATATTACTGCATATTGGAAAGGCTTTAAAGAATATCATGAAGCTAAAGGATCACAATTGCCGAAAA
TGTTTGGCTTCCAAGCTGAAGGCGCATCACCAATTGTTCAAAATAAAGTCATTAAAAATCCTGAAACGATTGCAACTGCT
ATTCGAATTGGTAATCCTGCTAGTTGGGATAAGGCGACTAATGCTCTTAAAGAATCAAATGGATTAATAGATAGTGTTAC
TGATGATGAAATTCTAGAAGCATATCAGTTAATGACAACTAAAGAAGGTGTCTTTAGTGAACCAGCGAGTAATGCTTCTA
TTGCAGGTTTAATTAAATTGCATAGACAAGGTAAATTACCTCAAGGTAAAAAAGTAGTTGCTATTTTAACTGGTAATGGA
TTAAAAGATCCTGATACTGCTATTTCACTACTAGATAATCCGATAAAGCCATTGCCAAATGATAAAGATAGCATTATCGA
TTATATTAAAGGAGCTTTATAA

Upstream 100 bases:

>100_bases
CCGCTGTTATAGTTGGATTGGAATCATCACCGGAAGAATTAATCACTAAGCATGGATACGAAGTTGACAAAGTATACCCA
GTAGAAGGAGTTTAATTATA

Downstream 100 bases:

>100_bases
CATGTCGAATGTTTTGGAGTTAACAATTCCTGCATCAACAGCCAACCTTGGAGTTGGCTTTGATTCTATAGGTATGGCTT
TAGATAAATTTTTGCATCTG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRRWQGLVEEFKAHLPVNENTPKLTLNEGNTPLIHCENMSKILGIDLYVKYEGANPTGSFKDRGMVMAVTKAKEQGKKIV
ICASTGNTSASAAAYAARAGLKAIVVIPEGKIALGKLSQAVMYGAEIVSIEGNFDEALEIVKEIAKSGEIELVNSVNPFR
IEGQKTGSFEIVQQLDGEAPDILAIPVGNAGNITAYWKGFKEYHEAKGSQLPKMFGFQAEGASPIVQNKVIKNPETIATA
IRIGNPASWDKATNALKESNGLIDSVTDDEILEAYQLMTTKEGVFSEPASNASIAGLIKLHRQGKLPQGKKVVAILTGNG
LKDPDTAISLLDNPIKPLPNDKDSIIDYIKGAL

Sequences:

>Translated_353_residues
MRRWQGLVEEFKAHLPVNENTPKLTLNEGNTPLIHCENMSKILGIDLYVKYEGANPTGSFKDRGMVMAVTKAKEQGKKIV
ICASTGNTSASAAAYAARAGLKAIVVIPEGKIALGKLSQAVMYGAEIVSIEGNFDEALEIVKEIAKSGEIELVNSVNPFR
IEGQKTGSFEIVQQLDGEAPDILAIPVGNAGNITAYWKGFKEYHEAKGSQLPKMFGFQAEGASPIVQNKVIKNPETIATA
IRIGNPASWDKATNALKESNGLIDSVTDDEILEAYQLMTTKEGVFSEPASNASIAGLIKLHRQGKLPQGKKVVAILTGNG
LKDPDTAISLLDNPIKPLPNDKDSIIDYIKGAL
>Mature_353_residues
MRRWQGLVEEFKAHLPVNENTPKLTLNEGNTPLIHCENMSKILGIDLYVKYEGANPTGSFKDRGMVMAVTKAKEQGKKIV
ICASTGNTSASAAAYAARAGLKAIVVIPEGKIALGKLSQAVMYGAEIVSIEGNFDEALEIVKEIAKSGEIELVNSVNPFR
IEGQKTGSFEIVQQLDGEAPDILAIPVGNAGNITAYWKGFKEYHEAKGSQLPKMFGFQAEGASPIVQNKVIKNPETIATA
IRIGNPASWDKATNALKESNGLIDSVTDDEILEAYQLMTTKEGVFSEPASNASIAGLIKLHRQGKLPQGKKVVAILTGNG
LKDPDTAISLLDNPIKPLPNDKDSIIDYIKGAL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=323, Percent_Identity=27.8637770897833, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=25.1655629139073, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367138, Length=320, Percent_Identity=25.9375, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790207, Length=146, Percent_Identity=34.2465753424658, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=296, Percent_Identity=27.3648648648649, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643623, Length=197, Percent_Identity=31.4720812182741, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129101, Length=197, Percent_Identity=31.4720812182741, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37870; Mature: 37870

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRWQGLVEEFKAHLPVNENTPKLTLNEGNTPLIHCENMSKILGIDLYVKYEGANPTGSF
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCCCCEEEEEEEEEEECCCCCCCC
KDRGMVMAVTKAKEQGKKIVICASTGNTSASAAAYAARAGLKAIVVIPEGKIALGKLSQA
CCCCEEEEEEEHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCEEHHHHHHH
VMYGAEIVSIEGNFDEALEIVKEIAKSGEIELVNSVNPFRIEGQKTGSFEIVQQLDGEAP
HHCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCCC
DILAIPVGNAGNITAYWKGFKEYHEAKGSQLPKMFGFQAEGASPIVQNKVIKNPETIATA
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHCCCCHHHEEE
IRIGNPASWDKATNALKESNGLIDSVTDDEILEAYQLMTTKEGVFSEPASNASIAGLIKL
EECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
HRQGKLPQGKKVVAILTGNGLKDPDTAISLLDNPIKPLPNDKDSIIDYIKGAL
HHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRRWQGLVEEFKAHLPVNENTPKLTLNEGNTPLIHCENMSKILGIDLYVKYEGANPTGSF
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCCCCEEEEEEEEEEECCCCCCCC
KDRGMVMAVTKAKEQGKKIVICASTGNTSASAAAYAARAGLKAIVVIPEGKIALGKLSQA
CCCCEEEEEEEHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCEEHHHHHHH
VMYGAEIVSIEGNFDEALEIVKEIAKSGEIELVNSVNPFRIEGQKTGSFEIVQQLDGEAP
HHCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCCC
DILAIPVGNAGNITAYWKGFKEYHEAKGSQLPKMFGFQAEGASPIVQNKVIKNPETIATA
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHCCCCHHHEEE
IRIGNPASWDKATNALKESNGLIDSVTDDEILEAYQLMTTKEGVFSEPASNASIAGLIKL
EECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
HRQGKLPQGKKVVAILTGNGLKDPDTAISLLDNPIKPLPNDKDSIIDYIKGAL
HHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]