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The map label for this gene is menA [H]

Identifier: 57650234

GI number: 57650234

Start: 1055402

End: 1056340

Strand: Reverse

Name: menA [H]

Synonym: SACOL1049

Alternate gene names: 57650234

Gene position: 1056340-1055402 (Counterclockwise)

Preceding gene: 57650240

Following gene: 57650232

Centisome position: 37.6

GC content: 34.93

Gene sequence:

>939_bases
ATGAGTAATCAATATCAGCAATATTCTACAGTTAAGAAATATTGGCATTTAATGCGTCCTCATACATTAACTGCTTCCGT
AGTACCCGTTTTAGTTGGTACAGCAGCATCTAAAATATATTTTCTTGGTAGCGAAGATCATATTAAAATCAGCCTATTCA
TTGCCATGTTACTAGCATGCTTACTTATTCAAGCAGCAACTAATATGTTTAATGAATACTATGATTATAAAAAAGGCCTT
GATGATCATGAATCTGTAGGCATTGGTGGTGCCATTGTTCGCAACGGTATGAGCCCAGAGCTTGTGCTACGATTAGCCAT
TGCATTTTACATCTTAGCAGCAATATTAGGTTTGTTTTTAGCTGCTAACTCTTCATTTTGGTTATTACCAGTTGGATTAG
TATGTATGGCTGTTGGTTACCTATATACAGGTGGCCCTTTCCCTATTTCATGGACGCCTTTCGGTGAATTATTCTCAGGC
GTATTTATGGGTATGTTTATTATCGTTATTGCATTCTTTATTCAAACTGGCAATATTCAAAGTTATGTAATTTGGTTAAG
TGTACCTATAGTAATCACTATCGGTTTAATTAATATGGCTAACAATATTCGCGACCGTGTCAAAGATAAAGCAAGTGGTC
GCAAAACTTTACCCATTCTATTAGGTAAAAATGCTTCTTTAACATTTATGGCAATCATGTACTTTATCGCTTATGCCTTT
ATTGTACTTACGATCATTATTAAACCTGGTGGCTCATTATTTTACTTACTTGCGTTGTTATCATTCCCAATGCCTGTTAA
AGTTATCAGACGTTTCAAGAAGAATGATACACCGCCTACAATGATGCCAGCAATGGCTGCTGCTGGTAAAACAAATACAT
TTTTCGGTTTATTATATGCATTAGGTATTTATATTAGTGCATTATTTGCAGGCATTTAA

Upstream 100 bases:

>100_bases
AAACTTATCTTGCAATTTTTCACGTCAATTGACCTTTATGCTACTTTCTATTAAAATATCTTTGTTATAAAAAATATGAT
TTAAAGAGGTTTTGTATTCA

Downstream 100 bases:

>100_bases
TAGAAAATGATACTACTCGGCAATCGACTTACATCGAACTGTCGAGTTTTTTTATTTAACAATTAAATGATGATACATGT
GCTTGTATAATTCAATCTGT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSNQYQQYSTVKKYWHLMRPHTLTASVVPVLVGTAASKIYFLGSEDHIKISLFIAMLLACLLIQAATNMFNEYYDYKKGL
DDHESVGIGGAIVRNGMSPELVLRLAIAFYILAAILGLFLAANSSFWLLPVGLVCMAVGYLYTGGPFPISWTPFGELFSG
VFMGMFIIVIAFFIQTGNIQSYVIWLSVPIVITIGLINMANNIRDRVKDKASGRKTLPILLGKNASLTFMAIMYFIAYAF
IVLTIIIKPGGSLFYLLALLSFPMPVKVIRRFKKNDTPPTMMPAMAAAGKTNTFFGLLYALGIYISALFAGI

Sequences:

>Translated_312_residues
MSNQYQQYSTVKKYWHLMRPHTLTASVVPVLVGTAASKIYFLGSEDHIKISLFIAMLLACLLIQAATNMFNEYYDYKKGL
DDHESVGIGGAIVRNGMSPELVLRLAIAFYILAAILGLFLAANSSFWLLPVGLVCMAVGYLYTGGPFPISWTPFGELFSG
VFMGMFIIVIAFFIQTGNIQSYVIWLSVPIVITIGLINMANNIRDRVKDKASGRKTLPILLGKNASLTFMAIMYFIAYAF
IVLTIIIKPGGSLFYLLALLSFPMPVKVIRRFKKNDTPPTMMPAMAAAGKTNTFFGLLYALGIYISALFAGI
>Mature_311_residues
SNQYQQYSTVKKYWHLMRPHTLTASVVPVLVGTAASKIYFLGSEDHIKISLFIAMLLACLLIQAATNMFNEYYDYKKGLD
DHESVGIGGAIVRNGMSPELVLRLAIAFYILAAILGLFLAANSSFWLLPVGLVCMAVGYLYTGGPFPISWTPFGELFSGV
FMGMFIIVIAFFIQTGNIQSYVIWLSVPIVITIGLINMANNIRDRVKDKASGRKTLPILLGKNASLTFMAIMYFIAYAFI
VLTIIIKPGGSLFYLLALLSFPMPVKVIRRFKKNDTPPTMMPAMAAAGKTNTFFGLLYALGIYISALFAGI

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=313, Percent_Identity=26.1980830670927, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1790365, Length=308, Percent_Identity=25.3246753246753, Blast_Score=75, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17737429, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34401; Mature: 34270

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQYQQYSTVKKYWHLMRPHTLTASVVPVLVGTAASKIYFLGSEDHIKISLFIAMLLAC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHH
LLIQAATNMFNEYYDYKKGLDDHESVGIGGAIVRNGMSPELVLRLAIAFYILAAILGLFL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AANSSFWLLPVGLVCMAVGYLYTGGPFPISWTPFGELFSGVFMGMFIIVIAFFIQTGNIQ
HCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SYVIWLSVPIVITIGLINMANNIRDRVKDKASGRKTLPILLGKNASLTFMAIMYFIAYAF
EEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
IVLTIIIKPGGSLFYLLALLSFPMPVKVIRRFKKNDTPPTMMPAMAAAGKTNTFFGLLYA
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHH
LGIYISALFAGI
HHHHHHHHHHCC
>Mature Secondary Structure 
SNQYQQYSTVKKYWHLMRPHTLTASVVPVLVGTAASKIYFLGSEDHIKISLFIAMLLAC
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHH
LLIQAATNMFNEYYDYKKGLDDHESVGIGGAIVRNGMSPELVLRLAIAFYILAAILGLFL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AANSSFWLLPVGLVCMAVGYLYTGGPFPISWTPFGELFSGVFMGMFIIVIAFFIQTGNIQ
HCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SYVIWLSVPIVITIGLINMANNIRDRVKDKASGRKTLPILLGKNASLTFMAIMYFIAYAF
EEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
IVLTIIIKPGGSLFYLLALLSFPMPVKVIRRFKKNDTPPTMMPAMAAAGKTNTFFGLLYA
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHH
LGIYISALFAGI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]