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The map label for this gene is uvrB

Identifier: 57650099

GI number: 57650099

Start: 845540

End: 847531

Strand: Direct

Name: uvrB

Synonym: SACOL0823

Alternate gene names: 57650099

Gene position: 845540-847531 (Clockwise)

Preceding gene: 57650098

Following gene: 57650100

Centisome position: 30.1

GC content: 35.09

Gene sequence:

>1992_bases
GTGACAATGGTTGAACATTATCCTTTTAAAATACATTCTGATTTTGAGCCTCAAGGTGACCAACCGCAAGCAATTAAAGA
AATCGTGGAAGGTATTAAAGCGGGGAAAAGACATCAAACTTTATTAGGTGCTACTGGCACAGGGAAAACATTTACGATGA
GTAATGTTATTAAAGAAGTTGGGAAACCAACGTTAATTATCGCGCATAACAAAACATTAGCAGGACAATTATATAGTGAG
TTTAAAGAATTTTTTCCTGAAAACAGGGTGGAATACTTTGTAAGTTACTATGATTATTATCAACCAGAGGCATACGTACC
GTCTACTGACACTTTTATTGAAAAAGATGCCTCAATCAATGATGAAATTGATCAACTACGACATTCTGCTACAAGTGCAT
TATTTGAACGCGATGATGTAATTATTATTGCTAGTGTAAGTTGTATATATGGTTTAGGTAATCCTGAAGAATATAAAGAT
TTAGTAGTAAGTGTTCGAGTTGGTATGGAAATGGATAGAAGTGAATTACTTAGAAAACTTGTAGATGTGCAATATACACG
AAATGACATCGATTTCCAACGAGGAACGTTTCGAGTGCGTGGTGATGTAGTGGAAATATTCCCAGCCTCTAAAGAAGAAC
TTTGTATAAGGGTTGAGTTTTTCGGCGATGAGATTGACCGTATCCGAGAAGTTAACTACCTAACAGGTGAAGTGTTGAAA
GAAAGAGAACATTTTGCGATATTCCCAGCTTCTCACTTCGTAACACGTGAAGAAAAGTTGAAAGTTGCGATTGAACGTAT
TGAAAAAGAATTGGAAGAACGATTGAAAGAATTACGAGATGAGAATAAATTACTAGAAGCGCAAAGGTTAGAACAGCGTA
CCAACTATGATTTAGAAATGATGCGAGAGATGGGATTCTGTTCAGGAATTGAAAACTATTCCGTACATTTAACTTTGCGA
CCACTGGGTTCGACACCATATACTTTATTGGATTACTTTGGCGATGATTGGTTAGTAATGATTGATGAATCACATGTGAC
ATTACCGCAAGTTCGAGGCATGTATAACGGAGACAGAGCGCGTAAACAAGTTTTGGTGGATCATGGGTTTAGATTACCGA
GTGCATTAGATAACCGTCCACTTAAATTTGAAGAATTTGAAGAAAAGACAAAACAACTTGTGTATGTATCTGCAACGCCT
GGACCATACGAAATTGAACATACGGATAAGATGGTTGAACAAATTATTCGTCCTACTGGTTTACTGGATCCTAAGATTGA
GGTTAGACCTACTGAAAATCAAATTGACGATTTATTAAGTGAAATTCAAACAAGAGTTGAGCGTAATGAACGCGTACTTG
TTACAACGCTCACTAAAAAGATGAGTGAAGATTTAACCACATACATGAAAGAAGCGGGTATTAAAGTTAATTATCTGCAT
TCAGAAATCAAGACATTAGAACGAATTGAAATAATTAGAGACTTACGAATGGGTACATATGATGTTATCGTAGGTATTAA
TTTATTAAGAGAGGGTATTGATATACCAGAAGTTTCTCTAGTTGTCATATTAGATGCAGATAAAGAAGGGTTTTTACGTT
CTAACCGCTCATTAATTCAAACAATAGGTAGAGCTGCGCGTAACGATAAAGGTGAAGTCATTATGTATGCCGATAAAATG
ACTGATTCGATGAAGTATGCAATTGATGAGACACAACGTCGTCGAGAAATACAGATGAAACATAATGAAAAACATGGTAT
TACACCTAAAACAATTAATAAAAAAATACATGATTTAATTAGTGCTACTGTTGAAAATGACGAAAATAATGACAAAGCAC
AAACTGTGATACCTAAGAAGATGACGAAAAAAGAACGTCAAAAGACAATCGACAATATAGAAAAAGAAATGAAACAAGCA
GCGAAAGATTTAGATTTCGAGAAAGCTACAGAATTAAGAGATATGTTATTTGAATTAAAAGCAGAAGGGTGA

Upstream 100 bases:

>100_bases
CAAACGTTTGCTTTTTGTGTGACTACTTTGCTAAAATATGTAATGAGAAAGCAAAGAGTTGAGCGGAAATATAAATAATA
CGTTGAAAGAGGAGGCATAT

Downstream 100 bases:

>100_bases
CAAGTAAATGAAAGAACCATCCATAGTAGTAAAAGGTGCTCGTGCGCATAACTTGAAAGATATTGATATCGAACTACCTA
AAAATAAATTAATTGTTATG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MTMVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSE
FKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKD
LVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLK
EREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLR
PLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATP
GPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLH
SEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKM
TDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQA
AKDLDFEKATELRDMLFELKAEG

Sequences:

>Translated_663_residues
MTMVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSE
FKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKD
LVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLK
EREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLR
PLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATP
GPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLH
SEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKM
TDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQA
AKDLDFEKATELRDMLFELKAEG
>Mature_662_residues
TMVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEF
KEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDL
VVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKE
REHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRP
LGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPG
PYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHS
EIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMT
DSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAA
KDLDFEKATELRDMLFELKAEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=58.3710407239819, Blast_Score=785, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_STAAC (Q5HHR0)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185697.1
- ProteinModelPortal:   Q5HHR0
- SMR:   Q5HHR0
- STRING:   Q5HHR0
- EnsemblBacteria:   EBSTAT00000010705
- GeneID:   3237964
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL0823
- TIGR:   SACOL0823
- eggNOG:   COG0556
- GeneTree:   EBGT00050000023889
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   SAUR93062:SACOL0823-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76882; Mature: 76751

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEV
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEHHHHHHHH
GKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASIN
CCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCC
DEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKL
HHHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
VDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLK
HHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
EREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEM
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRA
HHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCCHH
RKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTG
HHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHEEEEEECCCCCCEECHHHHHHHHHHCCCC
LLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLH
CCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEHH
SEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCCHHHHH
TIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLI
HHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELK
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AEG
CCC
>Mature Secondary Structure 
TMVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEV
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEHHHHHHHH
GKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASIN
CCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCC
DEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKL
HHHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
VDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLK
HHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
EREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEM
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRA
HHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCCHH
RKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTG
HHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHEEEEEECCCCCCEECHHHHHHHHHHCCCC
LLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLH
CCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEHH
SEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCCHHHHH
TIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLI
HHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELK
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AEG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA