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The map label for this gene is iolS [H]

Identifier: 57650066

GI number: 57650066

Start: 684230

End: 685168

Strand: Direct

Name: iolS [H]

Synonym: SACOL0655

Alternate gene names: 57650066

Gene position: 684230-685168 (Clockwise)

Preceding gene: 57650065

Following gene: 57650067

Centisome position: 24.35

GC content: 34.61

Gene sequence:

>939_bases
ATGAAGCAATTTGTAAACTTAGGTAAATCTGATGTTGAAGTGTTTCCAATCGCACTTGGGACGAACGCAGTAGGTGGGCA
TAATTTATATCCGAACTTAGATGAAGAACAAGGAAAAGATGTTGTTCGTCAAGCCATTAATCATGGTATTAATTTATTAG
ATACGGCATATATTTATGGGCCAGAACGATCAGAAGAATTGGTTGGAGAAGTTGTTAAAGAATATCCGCGAGAGCAAATT
AAAATTGCTACGAAAGGGTCTCATGAATTTGATGAAAATCAAGAAGTACATCAGAACAATCAACCGGAATATTTAAAACA
ACAAGTTGAGAATAGTTTGAAACGTCTACAAACTGATTATATCGATTTATATTATATTCATTTTCCGGATAACAACACTC
CGAAAGATCAAGCAGTTGCAGCATTACAAGAGCTTAAGGAACAAGGGAAGATTAAAGCAATTGGTGTATCAAATTTCACA
TTAGATCAACTTAAAGAAGCAAATAAAGATGGTTACGTTGATGTTGTACAGTTAGAATATAATTTATTGCATCGCGAAAA
TGAGGCAGTATTACAATATTGTGTTGATCACCAAATCACATTTATTCCATATTTCCCATTAGCATCCGGTATTTTAGCTG
GAAAATATGATGAGAACACTAAATTTAGTGACCATCGTACTACACGTCGTGATTTTAAACCAGGTGTATTTGAAGAAAAT
GTGCGTCGCGTAAAAGCTTTGGAAAGCATAGCTGCAGCACATCAAACTTCAATTGCGAACATTGTATTAGCATTTTATTT
AACGAGACCAGCTATCGATGTGATTATTCCTGGTGCAAAACGTGCAGAACAAGTCGTTGAAAATATTAAAGCTGCAGATA
TCGTTTTATCAGATGATGAGATTCAATATATCGATGAACTGTTTCCGATTGAAGACTAA

Upstream 100 bases:

>100_bases
ACACCGCTTAAATTCAAGCTCTAATTCTAACATTTGGAAGTTGTATTAAATCATGATAGTGTGATAGTGGAAAAGTTATA
AAGATAAGGAGCTGGGTCTA

Downstream 100 bases:

>100_bases
ATGAATTGTATTTAATGGTGATATATGTATCTAATTTCATCATGAATTAGCCCCGTATCACAAACGACGTTATATAAGGC
ATGACGAAATTTCGTCAAAT

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQI
KIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFT
LDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEEN
VRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED

Sequences:

>Translated_312_residues
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQI
KIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFT
LDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEEN
VRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED
>Mature_312_residues
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQI
KIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFT
LDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEEN
VRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=323, Percent_Identity=27.2445820433437, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4504825, Length=323, Percent_Identity=27.2445820433437, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436964, Length=324, Percent_Identity=25.6172839506173, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI27436962, Length=308, Percent_Identity=26.2987012987013, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI27436966, Length=306, Percent_Identity=26.4705882352941, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI27436971, Length=324, Percent_Identity=25.3086419753086, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI223718702, Length=296, Percent_Identity=27.027027027027, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI41152114, Length=296, Percent_Identity=28.3783783783784, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI41327764, Length=274, Percent_Identity=29.1970802919708, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=29.5918367346939, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI291291012, Length=294, Percent_Identity=28.2312925170068, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI223718708, Length=177, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=26.9360269360269, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=27.5, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI24497577, Length=299, Percent_Identity=26.4214046822742, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5174391, Length=299, Percent_Identity=26.4214046822742, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5453543, Length=294, Percent_Identity=26.530612244898, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI45446745, Length=299, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4503285, Length=299, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI24497585, Length=305, Percent_Identity=25.2459016393443, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI310109920, Length=299, Percent_Identity=25.752508361204, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI24497583, Length=306, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI300116273, Length=282, Percent_Identity=26.9503546099291, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788070, Length=322, Percent_Identity=33.2298136645963, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI87081735, Length=311, Percent_Identity=30.2250803858521, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789375, Length=323, Percent_Identity=28.4829721362229, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787674, Length=283, Percent_Identity=25.7950530035336, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789199, Length=345, Percent_Identity=30.1449275362319, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788081, Length=297, Percent_Identity=28.6195286195286, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082198, Length=274, Percent_Identity=28.1021897810219, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI48994888, Length=273, Percent_Identity=26.7399267399267, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786400, Length=272, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=299, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17564128, Length=302, Percent_Identity=27.1523178807947, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17561298, Length=309, Percent_Identity=27.5080906148867, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=27.4647887323944, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=311, Percent_Identity=25.08038585209, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17566692, Length=310, Percent_Identity=28.0645161290323, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17561300, Length=310, Percent_Identity=27.741935483871, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=283, Percent_Identity=25.7950530035336, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552492, Length=194, Percent_Identity=27.319587628866, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17537077, Length=283, Percent_Identity=24.7349823321555, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=330, Percent_Identity=27.8787878787879, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323998, Length=325, Percent_Identity=25.8461538461538, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319958, Length=298, Percent_Identity=26.1744966442953, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319951, Length=325, Percent_Identity=25.5384615384615, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322615, Length=252, Percent_Identity=25.7936507936508, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323684, Length=173, Percent_Identity=32.9479768786127, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646155, Length=198, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646159, Length=177, Percent_Identity=33.8983050847458, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=23.8255033557047, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35460; Mature: 35460

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYG
CCHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEC
PERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDY
CCCHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
IDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEY
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEEEEEEHH
NLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEEN
HHHHCCCHHHHHHHHHCCEEEEECHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHH
VRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHEEECCCH
IQYIDELFPIED
HHHHHHHCCCCC
>Mature Secondary Structure
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYG
CCHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEC
PERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDY
CCCHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
IDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEY
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEEEEEEHH
NLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEEN
HHHHCCCHHHHHHHHHCCEEEEECHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHH
VRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHEEECCCH
IQYIDELFPIED
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]