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The map label for this gene is echA2

Identifier: 41410047

GI number: 41410047

Start: 4410025

End: 4410936

Strand: Reverse

Name: echA2

Synonym: MAP3949c

Alternate gene names: 41410047

Gene position: 4410936-4410025 (Counterclockwise)

Preceding gene: 41410048

Following gene: 41410046

Centisome position: 91.33

GC content: 70.07

Gene sequence:

>912_bases
ATGCCCTCCGACTTCGAAACGCTGCTGTACACCACGGCCGGTCCGGTCGCCACGATCACGCTGAACCGCCCGGAGCAGCT
CAACACCATCGTGCCGCCGATGCCCGACGAGATCGAGGCCGCCGTTGGGCGGGCCGAGCGTGACCCGGCCATCAAGGTCA
TCGTGCTGCGCGGAGCGGGCCGGGCCTTCTCCGGCGGCTACGACTTCGGCGGCGGTTTTCAGCACTGGGGCGAGGCCATG
ATGACCGACGGCCGCTGGGACCCGGGCAAGGATTTCGCGATGGTCAGCGCCCGCGAGACCGGCCCGACCCAGAAATTCAT
GGCCATCTGGCGGGCGTCCAAACCGGTGATCGCGCAGGTGCACGGCTGGTGTGTGGGCGGGGCCAGCGACTACGCGCTGT
GCGCGGACCTGGTCATCGCCAGCGAGGACGCCGTGATCGGCACGCCCTACAGCAGGATGTGGGGGGCGTATCTGACCGGG
ATGTGGCTCTACCGGCTGAGCCTGGCCAAGGCGAAGTGGCATGCGCTGACGGGACGGCCGCTGACCGGCGTGCAGGCCGC
CGAGATCGAGCTGATCAACGAGGCGGTGCCGTTCGAGCGGCTGGAGGCGCGGGTCGCCGAGGTCGCCGCCGAGCTGGCGC
GCATCCCGCTGTCGCAGCTGCAGGCGCAGAAGCTGATCGTCAACCAGGCCTACGAGAACATGGGGCTGGCGTCCACCCAG
ACGCTGGGCGGCATCCTCGACGGGCTGATGCGCAACACCCCCGACGCGCTGGAGTTCATCAAGATCGCCGAGACGCGGGG
GGTGCGGGCCGCCGTCGAGCGCCGCGACGGCCCGTTCGGCGACTACAGCCAGGCCCCGCCGGAGCTGCGGCCCGATCCGA
GCCACGTCATCGTCCCTGATCGCGATGGATAG

Upstream 100 bases:

>100_bases
GGCCTTCTCGGCCTACCTCACCACCCCGTACCTGAAGATCAACGGCCGCATCTATGCGTCTTCGCCGGAAAACCGCGAGC
CCGATCCCTAAGTTGGGGCC

Downstream 100 bases:

>100_bases
TGAGATGCACTAGCGATCACCCTGGGGGTGACCTGGGAACTGTTCGCGCCGGGCCGAGAAGTGCTACCGTAACGTCTATG
TCTCGGCTGAGTAGAGGCCT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MPSDFETLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAVGRAERDPAIKVIVLRGAGRAFSGGYDFGGGFQHWGEAM
MTDGRWDPGKDFAMVSARETGPTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADLVIASEDAVIGTPYSRMWGAYLTG
MWLYRLSLAKAKWHALTGRPLTGVQAAEIELINEAVPFERLEARVAEVAAELARIPLSQLQAQKLIVNQAYENMGLASTQ
TLGGILDGLMRNTPDALEFIKIAETRGVRAAVERRDGPFGDYSQAPPELRPDPSHVIVPDRDG

Sequences:

>Translated_303_residues
MPSDFETLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAVGRAERDPAIKVIVLRGAGRAFSGGYDFGGGFQHWGEAM
MTDGRWDPGKDFAMVSARETGPTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADLVIASEDAVIGTPYSRMWGAYLTG
MWLYRLSLAKAKWHALTGRPLTGVQAAEIELINEAVPFERLEARVAEVAAELARIPLSQLQAQKLIVNQAYENMGLASTQ
TLGGILDGLMRNTPDALEFIKIAETRGVRAAVERRDGPFGDYSQAPPELRPDPSHVIVPDRDG
>Mature_302_residues
PSDFETLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAVGRAERDPAIKVIVLRGAGRAFSGGYDFGGGFQHWGEAMM
TDGRWDPGKDFAMVSARETGPTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADLVIASEDAVIGTPYSRMWGAYLTGM
WLYRLSLAKAKWHALTGRPLTGVQAAEIELINEAVPFERLEARVAEVAAELARIPLSQLQAQKLIVNQAYENMGLASTQT
LGGILDGLMRNTPDALEFIKIAETRGVRAAVERRDGPFGDYSQAPPELRPDPSHVIVPDRDG

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=292, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787660, Length=235, Percent_Identity=31.4893617021277, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787659, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI221142681, Length=275, Percent_Identity=26.5454545454545, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=239, Percent_Identity=28.0334728033473, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=224, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=133, Percent_Identity=30.8270676691729, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357171, Length=215, Percent_Identity=28.3720930232558, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650670, Length=270, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 32922; Mature: 32791

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDFETLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAVGRAERDPAIKVIVLRGAG
CCCCCCEEEEECCCCEEEEEECCCHHHCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECCC
RAFSGGYDFGGGFQHWGEAMMTDGRWDPGKDFAMVSARETGPTQKFMAIWRASKPVIAQV
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEE
HGWCVGGASDYALCADLVIASEDAVIGTPYSRMWGAYLTGMWLYRLSLAKAKWHALTGRP
CCEEECCCCCHHHHHHHHEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LTGVQAAEIELINEAVPFERLEARVAEVAAELARIPLSQLQAQKLIVNQAYENMGLASTQ
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHH
TLGGILDGLMRNTPDALEFIKIAETRGVRAAVERRDGPFGDYSQAPPELRPDPSHVIVPD
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECC
RDG
CCC
>Mature Secondary Structure 
PSDFETLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAVGRAERDPAIKVIVLRGAG
CCCCCEEEEECCCCEEEEEECCCHHHCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECCC
RAFSGGYDFGGGFQHWGEAMMTDGRWDPGKDFAMVSARETGPTQKFMAIWRASKPVIAQV
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEE
HGWCVGGASDYALCADLVIASEDAVIGTPYSRMWGAYLTGMWLYRLSLAKAKWHALTGRP
CCEEECCCCCHHHHHHHHEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LTGVQAAEIELINEAVPFERLEARVAEVAAELARIPLSQLQAQKLIVNQAYENMGLASTQ
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHH
TLGGILDGLMRNTPDALEFIKIAETRGVRAAVERRDGPFGDYSQAPPELRPDPSHVIVPD
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECC
RDG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA