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The map label for this gene is def

Identifier: 41410016

GI number: 41410016

Start: 4380091

End: 4380684

Strand: Reverse

Name: def

Synonym: MAP3918c

Alternate gene names: 41410016

Gene position: 4380684-4380091 (Counterclockwise)

Preceding gene: 41410024

Following gene: 41410015

Centisome position: 90.7

GC content: 70.54

Gene sequence:

>594_bases
ATGGCAGTCGTACCGATCCGCATCGTGGGAGATCCCGTCCTGCACACCCCGACACAGCCGGTGCCGGTCGGTGACGACGG
GTCCCTGCCGGCGGATCTGGGCAAGCTGATCGCCGACATGTACGACACCATGGACGCCGCCCACGGGGTCGGCCTGGCCG
CCAACCAGATCGGGGTGGGGTTGCGGGTGTTCGTCTACGACTGCGCCGACGACCGGGGGCTGACCGAGCGGCGCCGCGGC
GTGGTGGTCAACCCGGTGCTGGAGACCTCCGAGATCCCCGAGACCATGCCCGACCCGGACACCGACGACGAGGGCTGCCT
GTCGGTGCCCGGCGAATCGTTCCCCACCGGGCGGGCCAGCTGGGCACGGGTCACCGGGCTGGACGCCGACGGCAACCCGG
TGTCCATCGAGGGCCACGGCCTGTTCGCCCGGATGCTGCAGCACGAGACCGGGCACCTGGACGGCTTCCTGTATCTGGAC
CGGCTCATCGGCCGGTATGCCCGCAGCGCGAAACGGGCCGTCAAATCCCACAACTGGGGTGTGCCCGGCCTGTCCTGGAT
GCCCGGCGAGGGACCGGACCCGTTCGGTCACTGA

Upstream 100 bases:

>100_bases
ATTGAAACACGCCCCAAACCCTCAAGCCGTCATCCAGACCCGCGAGTCGGCCGATTGACCCAGATTGCCCACCCGCGAGC
GTGCGGTAGCTTAGCCGACC

Downstream 100 bases:

>100_bases
TGTTCTCGTGGCCCGACCCGGGGACCCGGGTGACGGTTCGCTACCGGCGCCCGCCCGGATCGGTGCCGCCGCTGACCGAC
GCGGTGGGCCGGCTGCTGAC

Product: peptide deformylase

Products: NA

Alternate protein names: PDF; Polypeptide deformylase

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MAVVPIRIVGDPVLHTPTQPVPVGDDGSLPADLGKLIADMYDTMDAAHGVGLAANQIGVGLRVFVYDCADDRGLTERRRG
VVVNPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRASWARVTGLDADGNPVSIEGHGLFARMLQHETGHLDGFLYLD
RLIGRYARSAKRAVKSHNWGVPGLSWMPGEGPDPFGH

Sequences:

>Translated_197_residues
MAVVPIRIVGDPVLHTPTQPVPVGDDGSLPADLGKLIADMYDTMDAAHGVGLAANQIGVGLRVFVYDCADDRGLTERRRG
VVVNPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRASWARVTGLDADGNPVSIEGHGLFARMLQHETGHLDGFLYLD
RLIGRYARSAKRAVKSHNWGVPGLSWMPGEGPDPFGH
>Mature_196_residues
AVVPIRIVGDPVLHTPTQPVPVGDDGSLPADLGKLIADMYDTMDAAHGVGLAANQIGVGLRVFVYDCADDRGLTERRRGV
VVNPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRASWARVTGLDADGNPVSIEGHGLFARMLQHETGHLDGFLYLDR
LIGRYARSAKRAVKSHNWGVPGLSWMPGEGPDPFGH

Specific function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

COG id: COG0242

COG function: function code J; N-formylmethionyl-tRNA deformylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polypeptide deformylase family

Homologues:

Organism=Escherichia coli, GI1789682, Length=163, Percent_Identity=34.9693251533742, Blast_Score=94, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24645728, Length=161, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24645726, Length=166, Percent_Identity=31.3253012048193, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEF_MYCPA (Q73T03)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962852.1
- HSSP:   P43522
- ProteinModelPortal:   Q73T03
- SMR:   Q73T03
- EnsemblBacteria:   EBMYCT00000039950
- GeneID:   2719324
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3918c
- NMPDR:   fig|262316.1.peg.3918
- GeneTree:   EBGT00050000016783
- HOGENOM:   HBG665227
- OMA:   FVYDCAD
- ProtClustDB:   PRK00150
- BRENDA:   3.5.1.88
- GO:   GO:0006412
- HAMAP:   MF_00163
- InterPro:   IPR000181
- Gene3D:   G3DSA:3.90.45.10
- PANTHER:   PTHR10458
- PIRSF:   PIRSF004749
- PRINTS:   PR01576
- TIGRFAMs:   TIGR00079

Pfam domain/function: PF01327 Pep_deformylase; SSF56420 Fmet_deformylase

EC number: =3.5.1.88

Molecular weight: Translated: 21061; Mature: 20930

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: ACT_SITE 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVPIRIVGDPVLHTPTQPVPVGDDGSLPADLGKLIADMYDTMDAAHGVGLAANQIGVG
CCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LRVFVYDCADDRGLTERRRGVVVNPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAS
EEEEEEECCCCCCCHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCC
WARVTGLDADGNPVSIEGHGLFARMLQHETGHLDGFLYLDRLIGRYARSAKRAVKSHNWG
CEEEECCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPGLSWMPGEGPDPFGH
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVVPIRIVGDPVLHTPTQPVPVGDDGSLPADLGKLIADMYDTMDAAHGVGLAANQIGVG
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LRVFVYDCADDRGLTERRRGVVVNPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAS
EEEEEEECCCCCCCHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCC
WARVTGLDADGNPVSIEGHGLFARMLQHETGHLDGFLYLDRLIGRYARSAKRAVKSHNWG
CEEEECCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPGLSWMPGEGPDPFGH
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA