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The map label for this gene is xthA

Identifier: 41410014

GI number: 41410014

Start: 4378465

End: 4379283

Strand: Reverse

Name: xthA

Synonym: MAP3916c

Alternate gene names: 41410014

Gene position: 4379283-4378465 (Counterclockwise)

Preceding gene: 41410015

Following gene: 41410013

Centisome position: 90.67

GC content: 70.57

Gene sequence:

>819_bases
GTGCGGCTGGCCACCTGGAATGTGAACTCGATTCGCTCCCGGCTGCCCCGGGTGCTGGACTGGCTGGCCCGCACCGAGGT
CGACGTGCTGGCCATGCAGGAGACCAAGTGCGCCGACGGCCAGTTCCCGACGTTGCCGTTCTTCGAACTCGGCTACGAGG
TCGCCCACGTCGGCTTCAACCAGTGGAACGGTGTGGCGATCGCCTCCCGGGTCGGCCTGGACGACGTGCGGGTCGGCTTC
GAGGGCCAGCCGAGCTGGAGCGGCAAGCCGGAGGTCGCCGCCGCCGCGGAGGCCCGCGCCCTGGCCGCCACCTGCGCCGG
TGTGCGGATCTGGAGCCTCTACGTTCCCAACGGCCGCGCGGTGGGCGACCCGCACTACGCCTACAAACTGGATTGGCTTG
CCGCCCTGCGTGATTCGGCCGCGGCCTGGCTGCGCGAGGATCCCGCCGCCCAGATCGCGCTGGCCGGGGACTGGAACATC
GCCCCACAGGACGACGACGTGTGGAGCATGGAGTTCTTCGCCGGCGCCACCCACGTCTCCGAGCCGGAGCGGCGCGCGTT
CAACGCCATCCTCGACGCGCAATTCGCGGACCTGGTACGGCCTTTCGCACCGGGCCCGGGGGTGTACACGTACTGGGACT
ACACCGCGCTGCGGTTCCCGAAACGGCAAGGCATGCGCATCGATTTCATCCTCGGCTCCCCCGCGTTGGCGCGCCGCGTG
ACGCACGCGCAGATCGACCGCGAGGAGCGCAAGGGCAAGGGCGCCAGCGATCACGCGCCGGTGCTGGTCGATGTGAGCCG
CGACGAGCCGCCGTCCTAG

Upstream 100 bases:

>100_bases
ACCGCGGCGCTGGAACTGGCCGGGGCGCTGGGTTTCCGGCTGCACCACCGGCGCCGCTACCTGACGGTCCCGGCCGGGCC
GGTGGGATAGTTTCTAGTCC

Downstream 100 bases:

>100_bases
GGAGAAATCCGGCACCGCTTCTCGTTGTCTGCCGCGCGGCAAGGTGGCAGGCTTTGCAAAATCAGGAGCGGAAACAGCAT
TGCCTAGTTGTTAAGCCTGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MRLATWNVNSIRSRLPRVLDWLARTEVDVLAMQETKCADGQFPTLPFFELGYEVAHVGFNQWNGVAIASRVGLDDVRVGF
EGQPSWSGKPEVAAAAEARALAATCAGVRIWSLYVPNGRAVGDPHYAYKLDWLAALRDSAAAWLREDPAAQIALAGDWNI
APQDDDVWSMEFFAGATHVSEPERRAFNAILDAQFADLVRPFAPGPGVYTYWDYTALRFPKRQGMRIDFILGSPALARRV
THAQIDREERKGKGASDHAPVLVDVSRDEPPS

Sequences:

>Translated_272_residues
MRLATWNVNSIRSRLPRVLDWLARTEVDVLAMQETKCADGQFPTLPFFELGYEVAHVGFNQWNGVAIASRVGLDDVRVGF
EGQPSWSGKPEVAAAAEARALAATCAGVRIWSLYVPNGRAVGDPHYAYKLDWLAALRDSAAAWLREDPAAQIALAGDWNI
APQDDDVWSMEFFAGATHVSEPERRAFNAILDAQFADLVRPFAPGPGVYTYWDYTALRFPKRQGMRIDFILGSPALARRV
THAQIDREERKGKGASDHAPVLVDVSRDEPPS
>Mature_272_residues
MRLATWNVNSIRSRLPRVLDWLARTEVDVLAMQETKCADGQFPTLPFFELGYEVAHVGFNQWNGVAIASRVGLDDVRVGF
EGQPSWSGKPEVAAAAEARALAATCAGVRIWSLYVPNGRAVGDPHYAYKLDWLAALRDSAAAWLREDPAAQIALAGDWNI
APQDDDVWSMEFFAGATHVSEPERRAFNAILDAQFADLVRPFAPGPGVYTYWDYTALRFPKRQGMRIDFILGSPALARRV
THAQIDREERKGKGASDHAPVLVDVSRDEPPS

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI18375503, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI18375501, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788046, Length=269, Percent_Identity=26.7657992565056, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 30107; Mature: 30107

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLATWNVNSIRSRLPRVLDWLARTEVDVLAMQETKCADGQFPTLPFFELGYEVAHVGFN
CEEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCHHHEECCCC
QWNGVAIASRVGLDDVRVGFEGQPSWSGKPEVAAAAEARALAATCAGVRIWSLYVPNGRA
CCCCEEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCC
VGDPHYAYKLDWLAALRDSAAAWLREDPAAQIALAGDWNIAPQDDDVWSMEFFAGATHVS
CCCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEHHHHHCCCCCC
EPERRAFNAILDAQFADLVRPFAPGPGVYTYWDYTALRFPKRQGMRIDFILGSPALARRV
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCCEEEEEECCHHHHHHH
THAQIDREERKGKGASDHAPVLVDVSRDEPPS
HHHHHCHHHHCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MRLATWNVNSIRSRLPRVLDWLARTEVDVLAMQETKCADGQFPTLPFFELGYEVAHVGFN
CEEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCHHHEECCCC
QWNGVAIASRVGLDDVRVGFEGQPSWSGKPEVAAAAEARALAATCAGVRIWSLYVPNGRA
CCCCEEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCC
VGDPHYAYKLDWLAALRDSAAAWLREDPAAQIALAGDWNIAPQDDDVWSMEFFAGATHVS
CCCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEHHHHHCCCCCC
EPERRAFNAILDAQFADLVRPFAPGPGVYTYWDYTALRFPKRQGMRIDFILGSPALARRV
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCCEEEEEECCHHHHHHH
THAQIDREERKGKGASDHAPVLVDVSRDEPPS
HHHHHCHHHHCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]