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The map label for this gene is cocE [H]

Identifier: 41408661

GI number: 41408661

Start: 2880669

End: 2882363

Strand: Direct

Name: cocE [H]

Synonym: MAP2563

Alternate gene names: 41408661

Gene position: 2880669-2882363 (Clockwise)

Preceding gene: 41408660

Following gene: 41408663

Centisome position: 59.64

GC content: 70.38

Gene sequence:

>1695_bases
GTGCCGCCCACTCGGATGACCGCGCTGGACCGTCCCTGGCGGCGCCCCGGCGCATTGCGCTACGCGCTGAACAGGATTCG
CGGCGTCGCCAAACCGCCCGTCACCGTCACCGACCCACCCGCGGACCTGCACGTCGAACGGGATGTCGCCGTCCCCACCC
GCGACGCAACGGTGTTGCGAATCAACGTCTTTCGCAAGCCGGACGCGGGGCCGCGACCGGTCATCCTGAGCATCCACCCG
TACGGCAAGGACAACCTGCCCAAGCGGCGGGGCAACCGGTGGACCTTTTCGGCGCAGTACCGGATACTGCGCCAGCCGCG
ACCGGTGACCTTCTCGGCGCTGACCGGTTGGGAAGCGCCCGATCCCGCCTGGTGGACGGCGCAGGGCTTCGTCGTGGTGA
ACGCCGACTCGCGCGGCTGCGGCCGTTCGGAGGGCACCGGAAACCTGTTGTCGCACCGCGAGGCCGAGGACACCTACGAC
CTGGTGCAGTGGATCGCCGGGCAGCCGTGGAGCGACGGCAACGTCGTCATGCTGGGGGTGTCCTACCTGGCCATCAGCCA
ATACGCGGTCGCCGCCCTGCAGCCGCCGGCGCTGCGGGCGATCTGCCCGTGGGAGGGCTTCACCGACGCCTACCGGGACC
TGATGTTTCCCGGCGGCGTGCGCGAGTTGGGCTTCATCCGAATGTGGTCACGCAATGTGCGACGCGATACCCGCCAGGCC
TACGACTTGCAGGACATGCAGGACCGCCACCCGCTGCGCGACGAGTTCTGGCGCTCGCTGGTGCCCGACCTGTCGGCGAT
CACCGTGCCCATGCTGGTCTGTGGCAGCTTCTCCGACAACAACTTACACAGCCGCGGCTCGCTGCGCGCCTTCACGCACA
GCAGCTCGACGCATGCCCGGCTCTACACCCATCGCGGCGGCAAGTGGGCGACCTTTTACGCCGAGGAGGCGCTGGCCGAA
CAGCTGAGCTTCTTTCGCGGTGTACTGGACGGGGCCCCGGCCGCTCGCAGCGTGCGCCTCGAGGTACGCGAGGACCGCGA
CACCGTCACGGCGGTGCGCGAAGAATCCGAATGGCCGCTGGCCCGAACCCGCTGGCGCGCACTGCATCTGGGTGACGCCG
GGGTGCTGAGAACCGACCCGGCCGCACAGCCGGGCAGGGTGACATTCGGAACACGTTCCCGCGCAGCATGTTTCACCTGG
AATGTGCCCGACGACGTGGAACTGACCGGGCCGATGGCCGCCCGGCTGTGGGTGGAACTGCACGGCTGCGACGACGCGAA
CCTGTTCGTCGGCGTGGAGAAGTGGCGCCCCGGCCGGTTCCGCGACCGCTTCGTCGCGTTCGAAGGGTCCTACGGCTACG
GCCGCGACCGGGTCAGCACCGGCTGGCAACGAGTTTCGCTGCGCGCCCTCGATTCCCGGCTGTCGCGGCCGGGACAGCCC
GTCGCGGCCTGCACCGATCCGCAACCCGTCGCGGCGGGCGAGGTCGTCGCGGTCGACGTCGCGCTGGGCCCGTCGGCGAC
GCTGTTCCGCGCCGGCGAGCACCTGCGGCTGGTGGTCGCCGGGCGCTGGCTGTGCCCGACCAATCCGCTCACCGGCCAGA
TCCCGGCCGCCTACCAGAACTCGCCGCGCGGTCGCGTCAGCCTGCACTGGGGTCCGCGCCGCGACGCGCATCTGCTGATC
CCCGAGATCCCCTGA

Upstream 100 bases:

>100_bases
TGCAGGAACTACCCGGATACCCCGACTACACCCAGAAGGTGCGCTACCGGCTGGCCCCCTACCTGTGGTAGGCGCGCCGC
CGAGCGCCTAGGGTATTGGC

Downstream 100 bases:

>100_bases
GCCGCCGAGCAGACGCAAAACCACCCGACACGCCGAAGAATTGGGGGTTTTTGCGTCTGCTCGCGGTGCGATGGCGACCT
TAGATCCAGACGCCCTTGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MPPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDPPADLHVERDVAVPTRDATVLRINVFRKPDAGPRPVILSIHP
YGKDNLPKRRGNRWTFSAQYRILRQPRPVTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSEGTGNLLSHREAEDTYD
LVQWIAGQPWSDGNVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAYRDLMFPGGVRELGFIRMWSRNVRRDTRQA
YDLQDMQDRHPLRDEFWRSLVPDLSAITVPMLVCGSFSDNNLHSRGSLRAFTHSSSTHARLYTHRGGKWATFYAEEALAE
QLSFFRGVLDGAPAARSVRLEVREDRDTVTAVREESEWPLARTRWRALHLGDAGVLRTDPAAQPGRVTFGTRSRAACFTW
NVPDDVELTGPMAARLWVELHGCDDANLFVGVEKWRPGRFRDRFVAFEGSYGYGRDRVSTGWQRVSLRALDSRLSRPGQP
VAACTDPQPVAAGEVVAVDVALGPSATLFRAGEHLRLVVAGRWLCPTNPLTGQIPAAYQNSPRGRVSLHWGPRRDAHLLI
PEIP

Sequences:

>Translated_564_residues
MPPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDPPADLHVERDVAVPTRDATVLRINVFRKPDAGPRPVILSIHP
YGKDNLPKRRGNRWTFSAQYRILRQPRPVTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSEGTGNLLSHREAEDTYD
LVQWIAGQPWSDGNVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAYRDLMFPGGVRELGFIRMWSRNVRRDTRQA
YDLQDMQDRHPLRDEFWRSLVPDLSAITVPMLVCGSFSDNNLHSRGSLRAFTHSSSTHARLYTHRGGKWATFYAEEALAE
QLSFFRGVLDGAPAARSVRLEVREDRDTVTAVREESEWPLARTRWRALHLGDAGVLRTDPAAQPGRVTFGTRSRAACFTW
NVPDDVELTGPMAARLWVELHGCDDANLFVGVEKWRPGRFRDRFVAFEGSYGYGRDRVSTGWQRVSLRALDSRLSRPGQP
VAACTDPQPVAAGEVVAVDVALGPSATLFRAGEHLRLVVAGRWLCPTNPLTGQIPAAYQNSPRGRVSLHWGPRRDAHLLI
PEIP
>Mature_563_residues
PPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDPPADLHVERDVAVPTRDATVLRINVFRKPDAGPRPVILSIHPY
GKDNLPKRRGNRWTFSAQYRILRQPRPVTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSEGTGNLLSHREAEDTYDL
VQWIAGQPWSDGNVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAYRDLMFPGGVRELGFIRMWSRNVRRDTRQAY
DLQDMQDRHPLRDEFWRSLVPDLSAITVPMLVCGSFSDNNLHSRGSLRAFTHSSSTHARLYTHRGGKWATFYAEEALAEQ
LSFFRGVLDGAPAARSVRLEVREDRDTVTAVREESEWPLARTRWRALHLGDAGVLRTDPAAQPGRVTFGTRSRAACFTWN
VPDDVELTGPMAARLWVELHGCDDANLFVGVEKWRPGRFRDRFVAFEGSYGYGRDRVSTGWQRVSLRALDSRLSRPGQPV
AACTDPQPVAAGEVVAVDVALGPSATLFRAGEHLRLVVAGRWLCPTNPLTGQIPAAYQNSPRGRVSLHWGPRRDAHLLIP
EIP

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 63095; Mature: 62964

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDPPADLHVERDVAVPTRDATVLR
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCCCCCCCCEEEE
INVFRKPDAGPRPVILSIHPYGKDNLPKRRGNRWTFSAQYRILRQPRPVTFSALTGWEAP
EEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEHEECCCCCEEEEEECCCCCC
DPAWWTAQGFVVVNADSRGCGRSEGTGNLLSHREAEDTYDLVQWIAGQPWSDGNVVMLGV
CCCEEEECCEEEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEH
SYLAISQYAVAALQPPALRAICPWEGFTDAYRDLMFPGGVRELGFIRMWSRNVRRDTRQA
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
YDLQDMQDRHPLRDEFWRSLVPDLSAITVPMLVCGSFSDNNLHSRGSLRAFTHSSSTHAR
CCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCCEEEEECCCCCCEE
LYTHRGGKWATFYAEEALAEQLSFFRGVLDGAPAARSVRLEVREDRDTVTAVREESEWPL
EEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHCCCCCCH
ARTRWRALHLGDAGVLRTDPAAQPGRVTFGTRSRAACFTWNVPDDVELTGPMAARLWVEL
HHHEEEEEEECCCCCEECCCCCCCCEEEECCCCCCEEEECCCCCCCEECCCEEEEEEEEE
HGCDDANLFVGVEKWRPGRFRDRFVAFEGSYGYGRDRVSTGWQRVSLRALDSRLSRPGQP
ECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCC
VAACTDPQPVAAGEVVAVDVALGPSATLFRAGEHLRLVVAGRWLCPTNPLTGQIPAAYQN
EEECCCCCCCCCCCEEEEEEECCCCCCEEECCCEEEEEEECCEECCCCCCCCCCCHHHCC
SPRGRVSLHWGPRRDAHLLIPEIP
CCCCEEEEEECCCCCCEEECCCCC
>Mature Secondary Structure 
PPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDPPADLHVERDVAVPTRDATVLR
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCCCCCCCCEEEE
INVFRKPDAGPRPVILSIHPYGKDNLPKRRGNRWTFSAQYRILRQPRPVTFSALTGWEAP
EEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEHEECCCCCEEEEEECCCCCC
DPAWWTAQGFVVVNADSRGCGRSEGTGNLLSHREAEDTYDLVQWIAGQPWSDGNVVMLGV
CCCEEEECCEEEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEH
SYLAISQYAVAALQPPALRAICPWEGFTDAYRDLMFPGGVRELGFIRMWSRNVRRDTRQA
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
YDLQDMQDRHPLRDEFWRSLVPDLSAITVPMLVCGSFSDNNLHSRGSLRAFTHSSSTHAR
CCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCCEEEEECCCCCCEE
LYTHRGGKWATFYAEEALAEQLSFFRGVLDGAPAARSVRLEVREDRDTVTAVREESEWPL
EEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHCCCCCCH
ARTRWRALHLGDAGVLRTDPAAQPGRVTFGTRSRAACFTWNVPDDVELTGPMAARLWVEL
HHHEEEEEEECCCCCEECCCCCCCCEEEECCCCCCEEEECCCCCCCEECCCEEEEEEEEE
HGCDDANLFVGVEKWRPGRFRDRFVAFEGSYGYGRDRVSTGWQRVSLRALDSRLSRPGQP
ECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCC
VAACTDPQPVAAGEVVAVDVALGPSATLFRAGEHLRLVVAGRWLCPTNPLTGQIPAAYQN
EEECCCCCCCCCCCEEEEEEECCCCCCEEECCCEEEEEEECCEECCCCCCCCCCCHHHCC
SPRGRVSLHWGPRRDAHLLIPEIP
CCCCEEEEEECCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]