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The map label for this gene is glcD [H]

Identifier: 41408615

GI number: 41408615

Start: 2827591

End: 2828958

Strand: Direct

Name: glcD [H]

Synonym: MAP2517

Alternate gene names: 41408615

Gene position: 2827591-2828958 (Clockwise)

Preceding gene: 41408614

Following gene: 41408616

Centisome position: 58.54

GC content: 70.69

Gene sequence:

>1368_bases
GTGAGCTCCGAAGCCTTGGCCAGCCTGATCGCCGACCTGCCCGACGGGACTGTGGTCACCGACCCGACGGTGACCGAGGG
CTACCGCCAGGACCGCGCGTTCGACCCGTCGGCCGGAAAACCGCTGGCCGTGGTGCGGCCGCGGCGCACCGAGGAGGTGC
AGACCGTGCTGCGCTGGGCGAGCGCGCACGGCGTCCCGGTGGTCACCCGCGGCGCGGGCAGCGGCCTGTCCGGCGGTGCG
ACCGCCCTGGACAACGGCATCGTGCTCTCGACGGAGAAGATGCGCGACATCACCGTCGACCCGGTGACCCGCACGGCGGT
TTGCCAGCCGGGGCTGTTCAACGCCGAGGTGAAGAAGGCGGCCGCCGAGCACGGCCTGTGGTATCCGCCGGACCCGTCGT
CGTTCGAGATCTGCAGCATCGGCGGCAACATCGCCACCAACGCCGGCGGCCTGTGCTGCGTGAAGTACGGCGTGACCACC
GACTACGTGCTGGGCATGCAGGTGGTGCTGGCCGACGGCACCGCCGTTCGGCTCGGCGGGCCGCGGCTCAAGGACGTCGC
GGGGCTGTCGTTGACGAAGCTGTTCGTCGGCAGCGAGGGCACCCTGGGCGTCATCACCGAGGTGACGCTGCGGCTGGTGC
CCAAGCAGAACACCTCCAGCGTCGTGGTGGCCAGCTTCGCCACGGTCGAGGATGCGGTCGGCGCGGTGCTCGGCGTCACC
GGGCGGCTGCGCCCGTCGATGCTGGAGTTCATGGACTCCGTCGCGATCAACGCCGTCGAGGACACCCTGCGGATGGACCT
GGACCGCGGCGCGGCCGCGATGCTGGTCGCCGGGTCCGACGAGCGTGGCCGCGCCGGCAGCGAGGACGCCGAGATCATGG
CCAAGGTGTTCGCGGAAAACGCTGCGACGGAAGTGTTTTCGACCGACGACCCGGACGAGGGCGAGGCATTCGTCGTCGCC
CGCCGATTCTGCATTCCGGCCGTGGAGGCCAAGGGGTCGTTGCTGCTCGAAGACGTCGGGGTGCCGCTTCCGGCGCTGGG
CCGGCTGGTCACCGGGATCGCGGCCATCGCCGCCGAACGTGACCTGATGATCTCGGTGATCGCCCACGCCGGCGACGGCA
ACACCCACCCGTTGATCGTCTACGACCCCGCCGATGCCGACATGACCGAGCGTGCACACCTGGCGTTCGGCGAGATCATG
GACCTGGCTGTCGGCCTGGGCGGCACCATCACCGGCGAGCACGGCGTCGGCCGGCTGAAGCGGCCCTGGCTGGCCGGCTA
CCTGGGGCCAGAGGTGATGGACCTCAACCGGCGGATCAAGCAGGCGCTGGACCCGCAGGGCATCTTGAACCCCGGGTCGG
GGATCTGA

Upstream 100 bases:

>100_bases
TCGGTGTCGTGGCCTGCGGCCTGCCGTCGCTGCGCGAACTGGACCGGGCACCGCAGTTCGCCGACGACCCGGGTCCGTGA
GGCGGGCTTAGGATCGGGCG

Downstream 100 bases:

>100_bases
GCTGTTTGTTGCCAAGTTGGCGCCGTGCGTCACGCTGGCGTGGCTTCGCCCGCCGAGCGTCACGCCAGCGTGGCTTCGCC
CGCCGAGCGTCACGCCAGCG

Product: hypothetical protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRTEEVQTVLRWASAHGVPVVTRGAGSGLSGGA
TALDNGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTT
DYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVT
GRLRPSMLEFMDSVAINAVEDTLRMDLDRGAAAMLVAGSDERGRAGSEDAEIMAKVFAENAATEVFSTDDPDEGEAFVVA
RRFCIPAVEAKGSLLLEDVGVPLPALGRLVTGIAAIAAERDLMISVIAHAGDGNTHPLIVYDPADADMTERAHLAFGEIM
DLAVGLGGTITGEHGVGRLKRPWLAGYLGPEVMDLNRRIKQALDPQGILNPGSGI

Sequences:

>Translated_455_residues
MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRTEEVQTVLRWASAHGVPVVTRGAGSGLSGGA
TALDNGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTT
DYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVT
GRLRPSMLEFMDSVAINAVEDTLRMDLDRGAAAMLVAGSDERGRAGSEDAEIMAKVFAENAATEVFSTDDPDEGEAFVVA
RRFCIPAVEAKGSLLLEDVGVPLPALGRLVTGIAAIAAERDLMISVIAHAGDGNTHPLIVYDPADADMTERAHLAFGEIM
DLAVGLGGTITGEHGVGRLKRPWLAGYLGPEVMDLNRRIKQALDPQGILNPGSGI
>Mature_454_residues
SSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRTEEVQTVLRWASAHGVPVVTRGAGSGLSGGAT
ALDNGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTD
YVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVTG
RLRPSMLEFMDSVAINAVEDTLRMDLDRGAAAMLVAGSDERGRAGSEDAEIMAKVFAENAATEVFSTDDPDEGEAFVVAR
RFCIPAVEAKGSLLLEDVGVPLPALGRLVTGIAAIAAERDLMISVIAHAGDGNTHPLIVYDPADADMTERAHLAFGEIMD
LAVGLGGTITGEHGVGRLKRPWLAGYLGPEVMDLNRRIKQALDPQGILNPGSGI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=437, Percent_Identity=30.8924485125858, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI37595754, Length=460, Percent_Identity=29.5652173913043, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI119964728, Length=470, Percent_Identity=31.063829787234, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4501993, Length=220, Percent_Identity=27.7272727272727, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=40.3341288782816, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI48994907, Length=213, Percent_Identity=33.8028169014084, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=24.4979919678715, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994914, Length=124, Percent_Identity=30.6451612903226, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992373, Length=474, Percent_Identity=32.9113924050633, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71992381, Length=474, Percent_Identity=31.8565400843882, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71992392, Length=382, Percent_Identity=32.9842931937173, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17534361, Length=421, Percent_Identity=28.7410926365796, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17556096, Length=255, Percent_Identity=25.4901960784314, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320027, Length=431, Percent_Identity=30.1624129930394, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320023, Length=440, Percent_Identity=29.0909090909091, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320764, Length=486, Percent_Identity=25.5144032921811, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18921117, Length=432, Percent_Identity=28.0092592592593, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639277, Length=432, Percent_Identity=28.0092592592593, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639275, Length=432, Percent_Identity=28.0092592592593, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24653753, Length=220, Percent_Identity=30.9090909090909, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 47409; Mature: 47277

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRTEEVQTVLRWA
CCHHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
SAHGVPVVTRGAGSGLSGGATALDNGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKA
HCCCCEEEEECCCCCCCCCCHHHCCCEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHH
AAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTDYVLGMQVVLADGTAVRLGG
HHHCCCCCCCCCCCEEEEECCCCEECCCCCEEEEEECCCCCHHCCEEEEEECCCEEEECC
PRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVT
CCHHHHCCCEEEEEEECCCCCEEHEEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHCCC
GRLRPSMLEFMDSVAINAVEDTLRMDLDRGAAAMLVAGSDERGRAGSEDAEIMAKVFAEN
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AATEVFSTDDPDEGEAFVVARRFCIPAVEAKGSLLLEDVGVPLPALGRLVTGIAAIAAER
HHHHCCCCCCCCCCCEEEEEHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
DLMISVIAHAGDGNTHPLIVYDPADADMTERAHLAFGEIMDLAVGLGGTITGEHGVGRLK
CEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
RPWLAGYLGPEVMDLNRRIKQALDPQGILNPGSGI
CCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRTEEVQTVLRWA
CHHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
SAHGVPVVTRGAGSGLSGGATALDNGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKA
HCCCCEEEEECCCCCCCCCCHHHCCCEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHH
AAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTDYVLGMQVVLADGTAVRLGG
HHHCCCCCCCCCCCEEEEECCCCEECCCCCEEEEEECCCCCHHCCEEEEEECCCEEEECC
PRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVT
CCHHHHCCCEEEEEEECCCCCEEHEEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHCCC
GRLRPSMLEFMDSVAINAVEDTLRMDLDRGAAAMLVAGSDERGRAGSEDAEIMAKVFAEN
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AATEVFSTDDPDEGEAFVVARRFCIPAVEAKGSLLLEDVGVPLPALGRLVTGIAAIAAER
HHHHCCCCCCCCCCCEEEEEHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
DLMISVIAHAGDGNTHPLIVYDPADADMTERAHLAFGEIMDLAVGLGGTITGEHGVGRLK
CEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
RPWLAGYLGPEVMDLNRRIKQALDPQGILNPGSGI
CCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]