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The map label for this gene is fadD1_1

Identifier: 41407562

GI number: 41407562

Start: 1602875

End: 1604494

Strand: Direct

Name: fadD1_1

Synonym: MAP1464

Alternate gene names: 41407562

Gene position: 1602875-1604494 (Clockwise)

Preceding gene: 41407561

Following gene: 41407569

Centisome position: 33.19

GC content: 68.83

Gene sequence:

>1620_bases
ATGATTGAGACGGTCCAGCAGCTGTTGCGGCAGCGCCGACACGACGACACCCCGGCGGTCGCATACGGCGACAAGACCTG
GACGTGGCGCGAGCACCTGGCCGAGGCCGAGGCCGAGGCGGCGGCGCTGATCGCCCGCGCCGACCCCGCCCGCCCGCTGC
ATGTCGGTGCGGCGCTGGGCAATTCACCGGCGATGCTGCGTGCCATGGCCGCCGCGGGGCTCGGCGGTTACGTCCTGTGC
GGGCTGAACACCACCCGCCGGGGATCAGCGCTGCTGTCCGACATCCACCGCTCCGACTGCCAGATCCTCCTTGTCGACGA
CGAGCACCTGCCGTTGCTGGACCGGTTGGACCTCAACGGAATTCAGGTTCTCGAGGTCGGGTCGCCGGCCTATGCCGATG
CGGTCGCCGCGGCGCCGCCGCTGATTCCGCACCGCGAGGTGACGGCGGCCGACCCGTTCATGATGATCTTCACCTCCGGC
ACCAGCGGCAATCCCAAGGCGGTCCGGTTCGCGCATGGGATGGCGATCATGTGCGGCGCCAGCCTCATCTTTCAATACGA
CGTCACCGCGGACGACGTCTGCTATCTGGCGATGCCGCTGTTTCATTCCAACGGCGTCGCCGCCGGGTGGGCCGTCGCGG
TCGGCAGTGGCGCGTTGATGGTTCCCGCCAAGTTCTCGCCGTCGCGGTTCCTCGACGACGTGCGCCGTTACCGGGTGACC
TACCTGAACTATGTCGGCAAGCCGCTGGCGCTGATCCTGTCCACTCCCGAGCGACCCGACGACGCCGACAACACGCTGCG
GGTGGCCTTCGGCAACGAGGCGACCGATCGCGACATCGCCGAATTCGCAAGGCGTTTCGGATGCCGGGTGGTGGACAGCT
TCGGCTCCAGCGAGTTCGCGGTGATCGTGGTGCGCGAAGACGGCACCCCGCCCGGCTCCATCGGCAGGCCGTATCCCGGG
GTCAGCATCTACAACCCGACCACCCTGAAGGAATGCGTCGTCACGCAGTTCGATGAGCACGGCGCGCTGACCAACTTCGA
GGAGGCGGTCGGCGAGCTGGTCAACACCCAGGGCGCCGGCCCGTTCGTCGGCTACTACAACGATCCGGAGGCGACGGCCG
AGCGGATGCGGCACGGCATGTACTGGTCGGGCGATCTGGCCTACCGCGACGCCGACGGGTGGATCTATCTGGCCGGCCGG
ACCGCGGATTGGATGCGGGTGGACGGGGAGAATCTGGCGGCCGCGCCGATCGAACGGATCCTGGCGCGGTTGCCTGACAT
CAGCCAGGTCGCCGTCTACGCGGTCCCCGACGAGCGGGTCGGTGACCAGGTGATGGCCGCGCTGGTGCTGCGCGCCGGGG
CGCAGCTGAGCCCGGAAGAATTCGGGCGATTCCTTGCGTCGCAGCCCGACTTGTCACCCAAGGCGTGGCCGCGCTACGTG
CGCATCAACGACCGGCTGCCCACCACCGCCACCAACAAGATCCTCAAGCGGGCGCTGATCTCCGCGGGCGTCACCGCGCA
CGACGGCGTGTTGTGGTCGCGTGCGCCGCGGGGCACCCGGTACGCCGTGGCGGGTGAAAATGCCGACGGCCCTGCAGCTT
CCGTGATCGCGGGGCAGTGA

Upstream 100 bases:

>100_bases
AACGAGTGTTCATGCCCTACATCGGAGGGTTCGGCACGTATCGGCGGCACTGCGAGCAGGTGGCCGACCGCGGCTATGCC
GGGCTGGTGCTGACGACACG

Downstream 100 bases:

>100_bases
CGCTACGCCGCCGCGTCGTCATCGTCTCCGCTGTCGTCGTCCTCCTCCTCGTCGCCATCGTCTTCCCCGTTGTCGTTCTC
CCCGCGGAGGAGTTTTTCGG

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MIETVQQLLRQRRHDDTPAVAYGDKTWTWREHLAEAEAEAAALIARADPARPLHVGAALGNSPAMLRAMAAAGLGGYVLC
GLNTTRRGSALLSDIHRSDCQILLVDDEHLPLLDRLDLNGIQVLEVGSPAYADAVAAAPPLIPHREVTAADPFMMIFTSG
TSGNPKAVRFAHGMAIMCGASLIFQYDVTADDVCYLAMPLFHSNGVAAGWAVAVGSGALMVPAKFSPSRFLDDVRRYRVT
YLNYVGKPLALILSTPERPDDADNTLRVAFGNEATDRDIAEFARRFGCRVVDSFGSSEFAVIVVREDGTPPGSIGRPYPG
VSIYNPTTLKECVVTQFDEHGALTNFEEAVGELVNTQGAGPFVGYYNDPEATAERMRHGMYWSGDLAYRDADGWIYLAGR
TADWMRVDGENLAAAPIERILARLPDISQVAVYAVPDERVGDQVMAALVLRAGAQLSPEEFGRFLASQPDLSPKAWPRYV
RINDRLPTTATNKILKRALISAGVTAHDGVLWSRAPRGTRYAVAGENADGPAASVIAGQ

Sequences:

>Translated_539_residues
MIETVQQLLRQRRHDDTPAVAYGDKTWTWREHLAEAEAEAAALIARADPARPLHVGAALGNSPAMLRAMAAAGLGGYVLC
GLNTTRRGSALLSDIHRSDCQILLVDDEHLPLLDRLDLNGIQVLEVGSPAYADAVAAAPPLIPHREVTAADPFMMIFTSG
TSGNPKAVRFAHGMAIMCGASLIFQYDVTADDVCYLAMPLFHSNGVAAGWAVAVGSGALMVPAKFSPSRFLDDVRRYRVT
YLNYVGKPLALILSTPERPDDADNTLRVAFGNEATDRDIAEFARRFGCRVVDSFGSSEFAVIVVREDGTPPGSIGRPYPG
VSIYNPTTLKECVVTQFDEHGALTNFEEAVGELVNTQGAGPFVGYYNDPEATAERMRHGMYWSGDLAYRDADGWIYLAGR
TADWMRVDGENLAAAPIERILARLPDISQVAVYAVPDERVGDQVMAALVLRAGAQLSPEEFGRFLASQPDLSPKAWPRYV
RINDRLPTTATNKILKRALISAGVTAHDGVLWSRAPRGTRYAVAGENADGPAASVIAGQ
>Mature_539_residues
MIETVQQLLRQRRHDDTPAVAYGDKTWTWREHLAEAEAEAAALIARADPARPLHVGAALGNSPAMLRAMAAAGLGGYVLC
GLNTTRRGSALLSDIHRSDCQILLVDDEHLPLLDRLDLNGIQVLEVGSPAYADAVAAAPPLIPHREVTAADPFMMIFTSG
TSGNPKAVRFAHGMAIMCGASLIFQYDVTADDVCYLAMPLFHSNGVAAGWAVAVGSGALMVPAKFSPSRFLDDVRRYRVT
YLNYVGKPLALILSTPERPDDADNTLRVAFGNEATDRDIAEFARRFGCRVVDSFGSSEFAVIVVREDGTPPGSIGRPYPG
VSIYNPTTLKECVVTQFDEHGALTNFEEAVGELVNTQGAGPFVGYYNDPEATAERMRHGMYWSGDLAYRDADGWIYLAGR
TADWMRVDGENLAAAPIERILARLPDISQVAVYAVPDERVGDQVMAALVLRAGAQLSPEEFGRFLASQPDLSPKAWPRYV
RINDRLPTTATNKILKRALISAGVTAHDGVLWSRAPRGTRYAVAGENADGPAASVIAGQ

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=530, Percent_Identity=28.3018867924528, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI62865631, Length=527, Percent_Identity=25.0474383301708, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13325055, Length=527, Percent_Identity=25.0474383301708, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13325057, Length=378, Percent_Identity=30.6878306878307, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI13236579, Length=380, Percent_Identity=29.7368421052632, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI38524616, Length=399, Percent_Identity=30.3258145363409, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI40807357, Length=545, Percent_Identity=26.7889908256881, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI187761345, Length=475, Percent_Identity=28.2105263157895, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI187761343, Length=475, Percent_Identity=28.2105263157895, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI227499621, Length=529, Percent_Identity=24.7637051039698, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI156151445, Length=363, Percent_Identity=25.6198347107438, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI8923896, Length=380, Percent_Identity=24.4736842105263, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI253970489, Length=380, Percent_Identity=24.4736842105263, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI42544132, Length=381, Percent_Identity=23.6220472440945, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI115511026, Length=395, Percent_Identity=24.8101265822785, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38505220, Length=368, Percent_Identity=25.2717391304348, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI122937307, Length=376, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI28416953, Length=525, Percent_Identity=21.1428571428571, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI221142682, Length=372, Percent_Identity=27.4193548387097, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693145, Length=380, Percent_Identity=27.1052631578947, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790505, Length=408, Percent_Identity=26.9607843137255, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786810, Length=352, Percent_Identity=26.1363636363636, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17551278, Length=371, Percent_Identity=27.4932614555256, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI115534440, Length=520, Percent_Identity=24.4230769230769, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=458, Percent_Identity=23.5807860262009, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=371, Percent_Identity=25.8760107816712, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=487, Percent_Identity=22.7926078028747, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=372, Percent_Identity=23.1182795698925, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=412, Percent_Identity=21.6019417475728, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=438, Percent_Identity=24.4292237442922, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71982997, Length=438, Percent_Identity=24.4292237442922, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=359, Percent_Identity=27.0194986072423, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323182, Length=391, Percent_Identity=24.8081841432225, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319264, Length=394, Percent_Identity=26.1421319796954, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319515, Length=494, Percent_Identity=22.4696356275304, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45552801, Length=546, Percent_Identity=25.2747252747253, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45550496, Length=546, Percent_Identity=25.2747252747253, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28573631, Length=472, Percent_Identity=26.6949152542373, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20130353, Length=472, Percent_Identity=26.6949152542373, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24583465, Length=534, Percent_Identity=24.5318352059925, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24583463, Length=534, Percent_Identity=24.5318352059925, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI281364798, Length=534, Percent_Identity=24.5318352059925, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24653035, Length=351, Percent_Identity=24.5014245014245, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18859661, Length=365, Percent_Identity=27.6712328767123, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648257, Length=357, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI161076582, Length=357, Percent_Identity=24.0896358543417, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21356441, Length=366, Percent_Identity=25.1366120218579, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355181, Length=362, Percent_Identity=27.3480662983425, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648260, Length=352, Percent_Identity=25.2840909090909, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20130357, Length=368, Percent_Identity=24.4565217391304, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356947, Length=350, Percent_Identity=25.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281365686, Length=333, Percent_Identity=23.4234234234234, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667955, Length=480, Percent_Identity=24.5833333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667959, Length=474, Percent_Identity=24.6835443037975, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI62472339, Length=480, Percent_Identity=24.5833333333333, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358303, Length=330, Percent_Identity=23.9393939393939, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648255, Length=354, Percent_Identity=25.4237288135593, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648253, Length=356, Percent_Identity=25.8426966292135, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 58178; Mature: 58178

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETVQQLLRQRRHDDTPAVAYGDKTWTWREHLAEAEAEAAALIARADPARPLHVGAALG
CHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEHCCC
NSPAMLRAMAAAGLGGYVLCGLNTTRRGSALLSDIHRSDCQILLVDDEHLPLLDRLDLNG
CCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCC
IQVLEVGSPAYADAVAAAPPLIPHREVTAADPFMMIFTSGTSGNPKAVRFAHGMAIMCGA
EEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEEEECC
SLIFQYDVTADDVCYLAMPLFHSNGVAAGWAVAVGSGALMVPAKFSPSRFLDDVRRYRVT
EEEEEECCCCCCCCEEEEHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHH
YLNYVGKPLALILSTPERPDDADNTLRVAFGNEATDRDIAEFARRFGCRVVDSFGSSEFA
HHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCEE
VIVVREDGTPPGSIGRPYPGVSIYNPTTLKECVVTQFDEHGALTNFEEAVGELVNTQGAG
EEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
PFVGYYNDPEATAERMRHGMYWSGDLAYRDADGWIYLAGRTADWMRVDGENLAAAPIERI
CEEEECCCHHHHHHHHHCCCEECCCEEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHH
LARLPDISQVAVYAVPDERVGDQVMAALVLRAGAQLSPEEFGRFLASQPDLSPKAWPRYV
HHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEE
RINDRLPTTATNKILKRALISAGVTAHDGVLWSRAPRGTRYAVAGENADGPAASVIAGQ
EECCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MIETVQQLLRQRRHDDTPAVAYGDKTWTWREHLAEAEAEAAALIARADPARPLHVGAALG
CHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEHCCC
NSPAMLRAMAAAGLGGYVLCGLNTTRRGSALLSDIHRSDCQILLVDDEHLPLLDRLDLNG
CCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCC
IQVLEVGSPAYADAVAAAPPLIPHREVTAADPFMMIFTSGTSGNPKAVRFAHGMAIMCGA
EEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEEEECC
SLIFQYDVTADDVCYLAMPLFHSNGVAAGWAVAVGSGALMVPAKFSPSRFLDDVRRYRVT
EEEEEECCCCCCCCEEEEHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHH
YLNYVGKPLALILSTPERPDDADNTLRVAFGNEATDRDIAEFARRFGCRVVDSFGSSEFA
HHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCEE
VIVVREDGTPPGSIGRPYPGVSIYNPTTLKECVVTQFDEHGALTNFEEAVGELVNTQGAG
EEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
PFVGYYNDPEATAERMRHGMYWSGDLAYRDADGWIYLAGRTADWMRVDGENLAAAPIERI
CEEEECCCHHHHHHHHHCCCEECCCEEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHH
LARLPDISQVAVYAVPDERVGDQVMAALVLRAGAQLSPEEFGRFLASQPDLSPKAWPRYV
HHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEE
RINDRLPTTATNKILKRALISAGVTAHDGVLWSRAPRGTRYAVAGENADGPAASVIAGQ
EECCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA