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The map label for this gene is trpA

Identifier: 41407405

GI number: 41407405

Start: 1394833

End: 1395648

Strand: Direct

Name: trpA

Synonym: MAP1307

Alternate gene names: 41407405

Gene position: 1394833-1395648 (Clockwise)

Preceding gene: 41407404

Following gene: 41407406

Centisome position: 28.88

GC content: 72.3

Gene sequence:

>816_bases
ATGACCGTCAAGCAGAGCCAGGCGAGCCGGCTGTCGCCGATCTTCGAGCCGTGCCGCGACGACGATCGGGCGGCGCTGAT
CGGTTACCTGCCCACCGGCTACCCGGACGTGCCGACCTCGGTGCAGGCGATGGTGGCGCTGGTCGAATCGGGTTGCGACA
TCGTCGAAGTCGGGGTGCCGTACTCGGATCCGGGGATGGACGGCCCGACCATCGCCCGGGCCACCGAGGCCGCGCTGCAC
GGCGGCGTGCGGGTGCGCGACACATTGGCCGCGGTCGAGGCGATCAGCGCGGCCGGCGGGCGCGCGGTGGTGATGACCTA
CTGGAACCCGGTGCTGCGCTACGGGGTCGACGCGTTCGCCCGCGACCTGGCCGCGGCCGGCGGCTACGGCCTGATCACGC
CCGACCTCATCCCCGACGAAGCCGGGCAGTGGCTGGCGGCCTCCGAGCGGCACGGGCTGGACCGGATCTTCCTGGTGGCG
CCGTCGTCGACGCCGCAGCGGTTGGCGCTGACGGTCGAGGCGTCGCGCGGATTCGTCTATGCGGCTTCGACGATGGGCGT
CACCGGGGCGCGCGACGCGGTGTCGCATGCCGCGCCGGAGTTGGTGAGCAGGGTCAGGGAGATCTCGGACATACCCGTCG
GGGTCGGGCTCGGGGTGCGCTCGCGCGAGCAAGCCGCCCAGATCGGCGGCTACGCCGACGGTGTCATCGTCGGGTCGGCG
CTGGTGTCGGCGCTGGGGGACGGAGGTTTGACCGCATTGCGTGCGCTGACTGAAGAACTCGCCGCCGGTGTTCGGCAGAG
GGCGGCCGCCTCGTGA

Upstream 100 bases:

>100_bases
TAGGTCGCGGCGCGATCATCGTGGTGAACCTGTCCGGGCGCGGGGACAAGGACGTCGAGACGGCGGCAAAGTGGTTCGGG
CTGTTGGGGTCCAGCGACCG

Downstream 100 bases:

>100_bases
CCAAGCTGCTCGCCTATTTCCCCAGCCCGCCGCAGGGCGTCTGGCATCTGGGACCGGTGCCGATCCGGGCCTACGCGTTG
TTCATCATCGCCGGGATCGT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTVKQSQASRLSPIFEPCRDDDRAALIGYLPTGYPDVPTSVQAMVALVESGCDIVEVGVPYSDPGMDGPTIARATEAALH
GGVRVRDTLAAVEAISAAGGRAVVMTYWNPVLRYGVDAFARDLAAAGGYGLITPDLIPDEAGQWLAASERHGLDRIFLVA
PSSTPQRLALTVEASRGFVYAASTMGVTGARDAVSHAAPELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSA
LVSALGDGGLTALRALTEELAAGVRQRAAAS

Sequences:

>Translated_271_residues
MTVKQSQASRLSPIFEPCRDDDRAALIGYLPTGYPDVPTSVQAMVALVESGCDIVEVGVPYSDPGMDGPTIARATEAALH
GGVRVRDTLAAVEAISAAGGRAVVMTYWNPVLRYGVDAFARDLAAAGGYGLITPDLIPDEAGQWLAASERHGLDRIFLVA
PSSTPQRLALTVEASRGFVYAASTMGVTGARDAVSHAAPELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSA
LVSALGDGGLTALRALTEELAAGVRQRAAAS
>Mature_270_residues
TVKQSQASRLSPIFEPCRDDDRAALIGYLPTGYPDVPTSVQAMVALVESGCDIVEVGVPYSDPGMDGPTIARATEAALHG
GVRVRDTLAAVEAISAAGGRAVVMTYWNPVLRYGVDAFARDLAAAGGYGLITPDLIPDEAGQWLAASERHGLDRIFLVAP
SSTPQRLALTVEASRGFVYAASTMGVTGARDAVSHAAPELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSAL
VSALGDGGLTALRALTEELAAGVRQRAAAS

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=267, Percent_Identity=26.2172284644195, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321412, Length=243, Percent_Identity=39.5061728395062, Blast_Score=175, Evalue=6e-45,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27942; Mature: 27811

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKQSQASRLSPIFEPCRDDDRAALIGYLPTGYPDVPTSVQAMVALVESGCDIVEVGVP
CCCCCCHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCC
YSDPGMDGPTIARATEAALHGGVRVRDTLAAVEAISAAGGRAVVMTYWNPVLRYGVDAFA
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
RDLAAAGGYGLITPDLIPDEAGQWLAASERHGLDRIFLVAPSSTPQRLALTVEASRGFVY
HHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCEEE
AASTMGVTGARDAVSHAAPELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHH
LVSALGDGGLTALRALTEELAAGVRQRAAAS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVKQSQASRLSPIFEPCRDDDRAALIGYLPTGYPDVPTSVQAMVALVESGCDIVEVGVP
CCCCCHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCC
YSDPGMDGPTIARATEAALHGGVRVRDTLAAVEAISAAGGRAVVMTYWNPVLRYGVDAFA
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
RDLAAAGGYGLITPDLIPDEAGQWLAASERHGLDRIFLVAPSSTPQRLALTVEASRGFVY
HHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCEEE
AASTMGVTGARDAVSHAAPELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHH
LVSALGDGGLTALRALTEELAAGVRQRAAAS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA