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The map label for this gene is ilvA

Identifier: 41407362

GI number: 41407362

Start: 1346080

End: 1347363

Strand: Direct

Name: ilvA

Synonym: MAP1264

Alternate gene names: 41407362

Gene position: 1346080-1347363 (Clockwise)

Preceding gene: 41407361

Following gene: 41407363

Centisome position: 27.87

GC content: 71.03

Gene sequence:

>1284_bases
GTGTCCGCCGAATTGAGCCAGTCCCCGAGCGTCGCGCCGCTTTCAGCGGCTGACATCGACGACGCGGCCAAGCGGATCGC
CGCGGTGGTCACGCCGACCCCGTTGCAGTTCAGCGACCGGCTGTCGGCGATCACCGGCGCACAGGTCTACCTCAAGCGCG
AGGACCTGCAGATCGTGCGCTCCTACAAGCTGCGCGGCGCCTACAACCTGCTGGTGCAGCTGTCCGAGACGGAGCTGGCC
GCGGGCGTGGTGTGCTCGTCGGCGGGCAATCACGCCCAGGGGTTCGCCTACGCGTGCCGGATGTTGCAGGTGCACGGCCG
CGTCTACGTGCCGGCCAAGACGCCGCTGCAGAAGCGGGACCGGATCCGCTACCACGGCGGGGAGTTCATCGAGCTGATCG
TCGGCGGAACCACCTACGACCAGGCCGCCGAGGCGGCGCTGGCCGACGTGGCGAGCACCGGCGCCACCCTCGTCCCGCCC
TATGACGATCTGCGCACCATCGCCGGCCAGGGCACCATCGCCGTCGAGCTGCTCGACCAGCTCGACACCGAGCCGGACCT
GGTGGTGGTCCCGGTGGGCGGCGGCGGCTGCATCGCCGGCATCACCACCTACCTCGCCGAGCGCACCGACACCACCGCGG
TGCTCGGCGTCGAGCCGGCCGGGGCCGCGGCGATGATGGCCGCCCTGGCGGCCGGCGAGCCGGTGACGCTGGACCACGTC
GACCAGTTCGTCGACGGTGCCGCGGTGCGGCGGGCCGGTGACCTGACCTACGCCGCGCTGGCGGCCGCCGGCGACATGGT
GTCGATCACCACGGTCGACGAGGGCGCGGTCTGCACCGCGATGCTCGACCTCTACCAGAACGAGGGCATCATCGCCGAGC
CCGCGGGCGCGCTGTCGGTCACCGGGTTGCTGGAGGCCGACATCGAACCCGGTTCGACGGTGGTCTGCCTGATCTCCGGC
GGCAACAACGACGTGTCGCGCTACGGCGAGGTGCTGGAGCGGTCCCTGGTGCACCTGGGCCTCAAGCACTACTTCCTGGT
CGACTTCCCGCAGGAGCCGGGCGCGCTGCGCCGGTTCCTCGACGAGGTGCTCGGCCCCAACGACGACATCACGCTGTTCG
AGTACGTCAAGCGCAACAACCGGGAGACCGGCGAGGCGCTGGTGGGCATCCAGCTGGGGTCCTCGGCCGACCTGGACGGC
CTGTTGGCCCGGATGCGGGCGACCGAGCTGCACGTCGAGACCCTGAAGCCGGGCTCGCCGGCCTACCGCTACCTGCTGCT
CTAA

Upstream 100 bases:

>100_bases
CCGAATACCAGACCAAAACCGACCGCCAGATCCCGGTATTCGTGCTGACCCCGGTCGCCTGAATTCCGTAGTTGACCAGC
CCGCATGGCACCATTAGTCC

Downstream 100 bases:

>100_bases
ATCCGATACATGCCCCCATCGTATGGACCCGGTCATGCCGGTTTCGGGCTGATCAGCGCCGCCGTCCTCGCGTCGCTGGT
GCTGCTGGGGTGGGCGGCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSAELSQSPSVAPLSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGAQVYLKREDLQIVRSYKLRGAYNLLVQLSETELA
AGVVCSSAGNHAQGFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAAEAALADVASTGATLVPP
YDDLRTIAGQGTIAVELLDQLDTEPDLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPVTLDHV
DQFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVTGLLEADIEPGSTVVCLISG
GNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSSADLDG
LLARMRATELHVETLKPGSPAYRYLLL

Sequences:

>Translated_427_residues
MSAELSQSPSVAPLSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGAQVYLKREDLQIVRSYKLRGAYNLLVQLSETELA
AGVVCSSAGNHAQGFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAAEAALADVASTGATLVPP
YDDLRTIAGQGTIAVELLDQLDTEPDLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPVTLDHV
DQFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVTGLLEADIEPGSTVVCLISG
GNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSSADLDG
LLARMRATELHVETLKPGSPAYRYLLL
>Mature_426_residues
SAELSQSPSVAPLSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGAQVYLKREDLQIVRSYKLRGAYNLLVQLSETELAA
GVVCSSAGNHAQGFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAAEAALADVASTGATLVPPY
DDLRTIAGQGTIAVELLDQLDTEPDLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPVTLDHVD
QFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVTGLLEADIEPGSTVVCLISGG
NNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSSADLDGL
LARMRATELHVETLKPGSPAYRYLLL

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=321, Percent_Identity=28.3489096573209, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19923959, Length=322, Percent_Identity=31.055900621118, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI33469958, Length=303, Percent_Identity=30.03300330033, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790207, Length=409, Percent_Identity=35.4523227383863, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789505, Length=322, Percent_Identity=34.1614906832298, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=379, Percent_Identity=32.9815303430079, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71991565, Length=325, Percent_Identity=32.9230769230769, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17508781, Length=286, Percent_Identity=27.6223776223776, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320930, Length=369, Percent_Identity=34.1463414634146, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6322631, Length=317, Percent_Identity=31.8611987381703, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21355833, Length=346, Percent_Identity=34.1040462427746, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=33.2, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 45045; Mature: 44913

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELSQSPSVAPLSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGAQVYLKREDLQIVR
CCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHHH
SYKLRGAYNLLVQLSETELAAGVVCSSAGNHAQGFAYACRMLQVHGRVYVPAKTPLQKRD
HHHHCCEEEEEEEECCHHHHHHEEECCCCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHC
RIRYHGGEFIELIVGGTTYDQAAEAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQ
CEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCEEHHHHHHH
LDTEPDLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPVTLDHV
HCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHH
DQFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSV
HHHHCCHHHHHCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCEEECCCCCEEE
TGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFL
EEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
DEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSP
HHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCCC
AYRYLLL
CEEEEEC
>Mature Secondary Structure 
SAELSQSPSVAPLSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGAQVYLKREDLQIVR
CCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHHH
SYKLRGAYNLLVQLSETELAAGVVCSSAGNHAQGFAYACRMLQVHGRVYVPAKTPLQKRD
HHHHCCEEEEEEEECCHHHHHHEEECCCCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHC
RIRYHGGEFIELIVGGTTYDQAAEAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQ
CEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCEEHHHHHHH
LDTEPDLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPVTLDHV
HCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHH
DQFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSV
HHHHCCHHHHHCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCEEECCCCCEEE
TGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFL
EEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
DEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSP
HHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCCC
AYRYLLL
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]