Click here to switch to the map view.

The map label for this gene is sucD

Identifier: 41406995

GI number: 41406995

Start: 925132

End: 926034

Strand: Direct

Name: sucD

Synonym: MAP0897

Alternate gene names: 41406995

Gene position: 925132-926034 (Clockwise)

Preceding gene: 41406994

Following gene: 41406996

Centisome position: 19.15

GC content: 66.22

Gene sequence:

>903_bases
ATGTCGATCTTTTTGAACAAGGACTCCAAGGTCATCGTCCAGGGCATCACCGGCGGCGAGGGCACCAAGCACACCGCGCT
GATGCTCAAGGCCGGAACCCAGGTGGTGGGCGGGGTCAACGCCCGCAAGGCCGGGACCACGGTTTCGCACGTGGACCCGG
TCGGCAAGGACGTCGAACTGCCGGTGTTCGGCACGGTGTCCGAGGCGATGAAGGAGACCGGCGCCAACGTGTCGGTGGTG
TTCGTGCCGCCGAAGTTCGCCAAGGACGCCATCATCGAGGCCATCGACGCCGAGATCCCGCTGCTGGTCGTCATCACCGA
GGGAATTCCGGTGCAGGACAGCGCATATGCGTGGGCCTACAACGTGGACAAGGGTCAGAAGACCCGCATCATCGGACCCA
ACTGCCCGGGCATCATCACGCCCGGTGAGGCGCTGGCCGGCATCACCCCGGCCAACATCAGCGGTCCCGGGCCGGTCGGG
CTGGTGTCCAAGTCCGGCACCCTGACCTACCAGATGATGTACGAGCTGCGCGATTTCGGGTTCTCCACCTCGATCGGCAT
CGGCGGTGACCCGATCATCGGCACCACCCACATCGACGCCATCGAGGCGTTCGAGAAGGACCCCGACACCAAGATCATCG
TGATGATCGGCGAGATCGGCGGCGACGCCGAGGAGCGCGCGGCCGACTACATCAAGGCCAACGTGTCCAAGCCGGTCGTC
GGCTATGTCGCGGGATTCACTGCGCCGGAAGGCAAGACGATGGGTCACGCCGGCGCCATCGTGTCCGGCTCGTCGGGCAC
CGCGGCCGCCAAGAAGGAGGCCCTGGAGGCCGCCGGCGTCAAGGTCGGCAAGACGCCGTCGGAGACGGCCGCGCTGGCCC
GAGAGATCCTGCAGAGCCTGTAG

Upstream 100 bases:

>100_bases
CCTCGCCGAAGCCAACCACCCGCTGGTGATCCAGGCCGAGACCATGGACTCCGGCGCCGACAAAGCCGCCGAGCTGGCGA
ACAAGTAAGGGAGCCAAGCC

Downstream 100 bases:

>100_bases
CGGCCCGCGGTGGGGCCCCGGATTTTGCCGGGGCCCGGCCCGCGGTAGATAGTGGGTCTATGAATCTCGACCCCAACACC
CCCGTCATCGTCGGGGTGGG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDPVGKDVELPVFGTVSEAMKETGANVSVV
FVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAYNVDKGQKTRIIGPNCPGIITPGEALAGITPANISGPGPVG
LVSKSGTLTYQMMYELRDFGFSTSIGIGGDPIIGTTHIDAIEAFEKDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAALAREILQSL

Sequences:

>Translated_300_residues
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDPVGKDVELPVFGTVSEAMKETGANVSVV
FVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAYNVDKGQKTRIIGPNCPGIITPGEALAGITPANISGPGPVG
LVSKSGTLTYQMMYELRDFGFSTSIGIGGDPIIGTTHIDAIEAFEKDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAALAREILQSL
>Mature_299_residues
SIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDPVGKDVELPVFGTVSEAMKETGANVSVVF
VPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAYNVDKGQKTRIIGPNCPGIITPGEALAGITPANISGPGPVGL
VSKSGTLTYQMMYELRDFGFSTSIGIGGDPIIGTTHIDAIEAFEKDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVVG
YVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAALAREILQSL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=48.6301369863014, Blast_Score=214, Evalue=5e-56,
Organism=Homo sapiens, GI38569423, Length=261, Percent_Identity=31.0344827586207, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI38569421, Length=261, Percent_Identity=31.0344827586207, Blast_Score=98, Evalue=7e-21,
Organism=Escherichia coli, GI1786949, Length=300, Percent_Identity=53.6666666666667, Blast_Score=295, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17550194, Length=293, Percent_Identity=51.5358361774744, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17553126, Length=293, Percent_Identity=48.8054607508532, Blast_Score=239, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17557344, Length=261, Percent_Identity=27.9693486590038, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17551266, Length=260, Percent_Identity=28.0769230769231, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=47.1186440677966, Blast_Score=226, Evalue=3e-60,
Organism=Drosophila melanogaster, GI21356559, Length=304, Percent_Identity=45.0657894736842, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI28574296, Length=305, Percent_Identity=46.5573770491803, Blast_Score=220, Evalue=7e-58,
Organism=Drosophila melanogaster, GI281363477, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363475, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363473, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30776; Mature: 30644

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDPVGKDVEL
CEEEEECCCEEEEEEECCCCCCCEEEEEEECCCCEECCCCCCCCCCCHHHCCCCCCCEEC
PVFGTVSEAMKETGANVSVVFVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAY
CEECCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEE
NVDKGQKTRIIGPNCPGIITPGEALAGITPANISGPGPVGLVSKSGTLTYQMMYELRDFG
ECCCCCEEEEECCCCCCEECCCHHHCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHCC
FSTSIGIGGDPIIGTTHIDAIEAFEKDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
CEEECCCCCCCCEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAALAREILQSL
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure 
SIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDPVGKDVEL
EEEEECCCEEEEEEECCCCCCCEEEEEEECCCCEECCCCCCCCCCCHHHCCCCCCCEEC
PVFGTVSEAMKETGANVSVVFVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAY
CEECCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEE
NVDKGQKTRIIGPNCPGIITPGEALAGITPANISGPGPVGLVSKSGTLTYQMMYELRDFG
ECCCCCEEEEECCCCCCEECCCHHHCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHCC
FSTSIGIGGDPIIGTTHIDAIEAFEKDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
CEEECCCCCCCCEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAALAREILQSL
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]