Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 52842920

GI number: 52842920

Start: 3065606

End: 3067546

Strand: Reverse

Name: thrS

Synonym: lpg2714

Alternate gene names: 52842920

Gene position: 3067546-3065606 (Counterclockwise)

Preceding gene: 52842923

Following gene: 52842919

Centisome position: 90.28

GC content: 41.01

Gene sequence:

>1941_bases
CTGAAAGATGGAAAGACGGATAAGATTATGCCAAATGTTAAATTACCAGATGGAAATGTAAAACATTTTGAAGCGCCACT
CACTATTTATGATGTGGCACATCACATTAGCCCTGGATTAGCTAAAGCAGCGATAGCAGGCCGTGTCGATGGCGTCTTGG
TGGATACATCCTATCTTATAAAAGAAGACTGCTCTTTGATTATCGTAACCGAGAAACATGAAGACAGTCTTGAAATAATC
AGGCATTCTACCGCTCATTTATTAGCTCAGGCTGTAAAAGCCTTATTTCCATCCGCTCAAGTGACTATAGGTCCTGTAAT
AGAAGACGGGTTTTATTATGATTTTGCTTTTGAGCGCTCGTTTACTCCCGATGATTTGAGTTTAATCGAAGCGAAGATGC
ATGAGCTGGCAAAGGCTAATCTTTCGATCACTCGTCGAGAATTACCTAGAAATGAAGCAATACAATATTTTAAGGATTTA
GGCGAAGAATATAAGGCAAAAATTATTGCTGATATACCCGAAAATGAAGCGCTCTCTCTATATAGGCAAGGTGATTTTGA
AGATTTGTGTCGAGGTCCACATGTCCCCTCCACTGGGTTTTTAAAAGCATTTAAATTGACAAAAGTAGCTGGCGCTTATT
GGCGTGGTGACTCAAATAACGAAATGTTGCAGCGAATTTACGGCACTGCCTGGGCTGATAAAAAATCCCTGGAAGAATAT
TTGTTTCGTTTGGAAGAAGCAGAAAAACGTGATCATCGTAAATTAGGCAAGGCACTGGATTTGTTTCATTTCCAGGATAT
TGCTCCGGGAATGGTTTTTTGGCACCCCAAAGGATGGACTATTTATCAAGAGCTAGAGCATTACATGCGAAATCGCCTGG
TCGATTTTGGCTATCAGGAAATTAGAACACCGCAATTAGTAGACAGATCGTTATGGGAGAAATCAGGTCATTGGGCGAAC
TTTAGAGATGAAATGTTTGTTACCGAAACAGAGAATCGACATTATGCAGTAAAACCTATGAGCTGTCCCTGCCACGTTCA
AATTTATAATCATGGTTTGAAAAGTTACCGGGATCTTCCTCTCAGACTATCTGAGTTTGGAAATTGTCATCGCTGTGAGC
CATCAGGCGCGCTGCATGGGTTGATGCGGGTACGCAATATGGTGCAGGATGATGCTCATATTTTTTGCACTGAGGATCAG
ATTCAATCTGAAGTGGCTATGATGCTGGAGTTAGTGCAATCCGTATATAAGGACTTTGGGTTTACTGAAATAAAATACCG
ATTGGCTTTGCGCCCTGAAAAACGAGTCGGTTCAGATGACGTTTGGGATAAGGCGGAAACCGCCCTTAAACTGGCTATGC
AGGGAAGAAATATTGAGTGGGTGGATGCGCCTGGAGAAGGAGCATTTTATGGACCTAAAATTGAATGCTCTCTCTCTGAT
TGTTTAGGTAGAATTTGGCAGTGCGGAACGATTCAAGTGGATTTCTCTATGCCTGCACGCCTTGAAGCAAGCTATGTTGC
TGAAGATGGAAGCAAGCAAACACCGGTGATGTTGCATAGAGCCATTTTGGGTTCTTTCGAACGATTTATGGGAATATTAA
TCGAACATTATGCAGGTAAATTGCCATTATGGTTATCCCCAGTGCAAGCGATTGTGCTTACTATTAGTGAGAAGCAGAAT
GAGTATGCCGAAAAAGTGAGGAAAACTTTGCAAAAAAGAGGGATTCGCGCCAATTTTGACTTGAGAAATGAAAAGATTGG
ATTTAAAATTCGCGAGCATACTTTACAAAAAATTCCTTATTTATTGGTTGTTGGCGATAAAGAGGTTGAAAATTGTCAGG
TAGCTGTTCGCACTCGAGATGGCATTGACCTGGGTGTGATGACAATAGATACAATTTGTGATACCTTAACGCAAGAAATT
ATCCGTAAAGGATCAATATAA

Upstream 100 bases:

>100_bases
AATTCCTGGATTTCTAGTAGAATCCCTAAATTGGTAAACTACTGCACTGAATTATTAAAGGTTTGAACCCTGCCATGCAG
GGTTTTTTTTTAACAAGAAC

Downstream 100 bases:

>100_bases
ATAAACGAACTGGAGGATTAAACCATTAGTGCACCAACTAAGCGTGAAAATGATCGCGCACGAATTAATGAACAGATCAC
TGTACCTGAGGTACGCTTAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MKDGKTDKIMPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIVTEKHEDSLEII
RHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLIEAKMHELAKANLSITRRELPRNEAIQYFKDL
GEEYKAKIIADIPENEALSLYRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEY
LFRLEEAEKRDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDRSLWEKSGHWAN
FRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQ
IQSEVAMMLELVQSVYKDFGFTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSD
CLGRIWQCGTIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQAIVLTISEKQN
EYAEKVRKTLQKRGIRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEI
IRKGSI

Sequences:

>Translated_646_residues
MKDGKTDKIMPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIVTEKHEDSLEII
RHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLIEAKMHELAKANLSITRRELPRNEAIQYFKDL
GEEYKAKIIADIPENEALSLYRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEY
LFRLEEAEKRDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDRSLWEKSGHWAN
FRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQ
IQSEVAMMLELVQSVYKDFGFTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSD
CLGRIWQCGTIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQAIVLTISEKQN
EYAEKVRKTLQKRGIRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEI
IRKGSI
>Mature_646_residues
MKDGKTDKIMPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIVTEKHEDSLEII
RHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLIEAKMHELAKANLSITRRELPRNEAIQYFKDL
GEEYKAKIIADIPENEALSLYRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEY
LFRLEEAEKRDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDRSLWEKSGHWAN
FRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQ
IQSEVAMMLELVQSVYKDFGFTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSD
CLGRIWQCGTIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQAIVLTISEKQN
EYAEKVRKTLQKRGIRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEI
IRKGSI

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=630, Percent_Identity=40.3174603174603, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI38570111, Length=639, Percent_Identity=38.810641627543, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=637, Percent_Identity=37.2056514913658, Blast_Score=412, Evalue=1e-115,
Organism=Escherichia coli, GI1788013, Length=632, Percent_Identity=57.4367088607595, Blast_Score=788, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=624, Percent_Identity=40.224358974359, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71984184, Length=624, Percent_Identity=40.224358974359, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322112, Length=641, Percent_Identity=39.1575663026521, Blast_Score=462, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322654, Length=392, Percent_Identity=38.265306122449, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24583842, Length=629, Percent_Identity=38.9507154213037, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI28574141, Length=629, Percent_Identity=38.9507154213037, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24583839, Length=629, Percent_Identity=38.9507154213037, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73913; Mature: 73913

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDGKTDKIMPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLI
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHH
KEDCSLIIVTEKHEDSLEIIRHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERS
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCEEEEEEECCC
FTPDDLSLIEAKMHELAKANLSITRRELPRNEAIQYFKDLGEEYKAKIIADIPENEALSL
CCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHH
YRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEY
HCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHH
LFRLEEAEKRDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHH
IRTPQLVDRSLWEKSGHWANFRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLP
CCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEEHHHCCHHHHCCCC
LRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMMLELVQSVYKDFG
CCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
FTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSD
CEEEEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEECCEEEEEHHH
CLGRIWQCGTIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGK
HHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LPLWLSPVQAIVLTISEKQNEYAEKVRKTLQKRGIRANFDLRNEKIGFKIREHTLQKIPY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCE
LLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI
EEEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKDGKTDKIMPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLI
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHH
KEDCSLIIVTEKHEDSLEIIRHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERS
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCEEEEEEECCC
FTPDDLSLIEAKMHELAKANLSITRRELPRNEAIQYFKDLGEEYKAKIIADIPENEALSL
CCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHH
YRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEY
HCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHH
LFRLEEAEKRDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHH
IRTPQLVDRSLWEKSGHWANFRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLP
CCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEEHHHCCHHHHCCCC
LRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMMLELVQSVYKDFG
CCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
FTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSD
CEEEEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEECCEEEEEHHH
CLGRIWQCGTIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGK
HHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LPLWLSPVQAIVLTISEKQNEYAEKVRKTLQKRGIRANFDLRNEKIGFKIREHTLQKIPY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCE
LLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI
EEEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA