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The map label for this gene is pepA [H]

Identifier: 52842840

GI number: 52842840

Start: 2974841

End: 2976205

Strand: Reverse

Name: pepA [H]

Synonym: lpg2634

Alternate gene names: 52842840

Gene position: 2976205-2974841 (Counterclockwise)

Preceding gene: 52842841

Following gene: 52842839

Centisome position: 87.59

GC content: 42.34

Gene sequence:

>1365_bases
ATGCAAGCAGAAGTATTTTACAAAAGTTGCGGCGATAGGATAGTTCCTGTCCATCTCATTTCTCAATCACAATGGGACGA
AGGAATTGAAAATCTAACCCCCATGGAACGAAATTGTTTTTCTGTACGCCAGTTTAAGGGCAAATTAGGCGATTATTGTT
TTATCCTCAATGCGGATGGCGTGATTGAAAAAGCTTTTATTGGATCGGGAACTGGCAATCAGGAAAGTGCTTTGGCCAAT
GCAGCACTTTTATTGCCTCCAGGGAACTATCAATTTCAAGATAAGTTAAGTCGTGAGTCTGGCGTAGTTTGGGCATTAGC
GCAATATCGATTTGATGAGTATAAAAAGTACGAGTTACAGCCTCGAGTTTTAATTGTTGAGGCAAATGATATGGATTATA
TTTTATCCTTGGCGAATTCTTTATTTCTCGTGCGCGATCTAATTAACACGCCAACCTGCGATATGGGGCCAGAATCGTTA
GCTCATGTTGTCGAAGAATTGGCTAAAACACACAAGGCTTACTTTAAACAATGGATTGGAGAGGAATTGATAAAGGATAA
TTTTCCTGCCATTCATGCGGTTGGAAGAGCTTCTGCTTTAACGCCTCGTTTATTATCCTTGCAGTGGGGAAATGAGAAAC
ATCCACGCGTAACTTTGATTGGAAAGGGTGTTTGTTTTGATAGCGGCGGGCTTGATATCAAACCTTCATCAGGCATGCGT
TTGATGAAAAAAGATATGGGCGGCGCCGCACACGTCATAGGTTTAGCCCAGTGGATCATGGTTCAGCGTTTGCCGATTCG
ATTACAGGTATTAATCCCCGCTGTTGAAAACGCCATTGGTCCGAATGCTTTTAGGCCAGGAGATGTTTTAACCATGCGCA
ACGGATTAACCGTAGAAATAGAAAACACTGATGCAGAAGGTCGATTGATTCTGGCAGATGCTTTGGTTAAGGCTTGTGAA
GAAAAACCAGATTTGATCATTGATTTTGCTACTTTAACAGGTGCTGCTCGTGTCGCTGTCGGAACTGAAATTGCAGCCAT
GTTTTCTAATCATGATCAACTGGCTCAGGATATAGTAGCGGCATCTAATAAAGTCTCAGACCCTGTCTGGCGGTTGCCTT
TATTTTCACCATACGAAGAGTTATTGAATTCGAATATTGCAGACATGAGCAATTCCAGTTCTTCGTCCTATGCTGGGGCT
ATTACTGCCGGCTTATTTCTACAACGATTTGTGACAAAATCAATACCATGGGTTCATTTTGATATCATGGCCTGGAATGC
AGTAAGTAAGCCAGGAAAGCCAGAAGGTGGTGAAGCAATGGGCTTGCGAGCTGTTGCTGAGTATTTATTACAGACTTACG
GATAG

Upstream 100 bases:

>100_bases
TTAGCTCATGTGTTCGTCACCGTAGTCATCTATTTATTAGTTTTAGGTATAATAGGGCTTAGGCCTAGCCACTTTCGTGG
CCAGATAAAGGATTAAAAAG

Downstream 100 bases:

>100_bases
AATTTTCAGTTGGGAGCTAGTTATGTTTGTGACTTTTAGTTGTGATGCATATGAGAACATTACTTATTTTGAAAATGTGG
CAAAACAATTATTGTTGTTA

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADGVIEKAFIGSGTGNQESALAN
AALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQPRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESL
AHVVEELAKTHKAYFKQWIGEELIKDNFPAIHAVGRASALTPRLLSLQWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALVKACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVTKSIPWVHFDIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG

Sequences:

>Translated_454_residues
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADGVIEKAFIGSGTGNQESALAN
AALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQPRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESL
AHVVEELAKTHKAYFKQWIGEELIKDNFPAIHAVGRASALTPRLLSLQWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALVKACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVTKSIPWVHFDIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG
>Mature_454_residues
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADGVIEKAFIGSGTGNQESALAN
AALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQPRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESL
AHVVEELAKTHKAYFKQWIGEELIKDNFPAIHAVGRASALTPRLLSLQWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALVKACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVTKSIPWVHFDIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=321, Percent_Identity=36.7601246105919, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI47155554, Length=306, Percent_Identity=33.9869281045752, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI87082123, Length=358, Percent_Identity=37.7094972067039, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1790710, Length=367, Percent_Identity=38.1471389645777, Blast_Score=211, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17556903, Length=360, Percent_Identity=33.0555555555556, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=179, Percent_Identity=35.195530726257, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221379063, Length=302, Percent_Identity=33.7748344370861, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI221379062, Length=302, Percent_Identity=33.7748344370861, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI21357381, Length=302, Percent_Identity=33.7748344370861, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21355725, Length=329, Percent_Identity=32.5227963525836, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24661038, Length=331, Percent_Identity=33.2326283987915, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI161077148, Length=334, Percent_Identity=29.3413173652695, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI20130057, Length=334, Percent_Identity=29.3413173652695, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24662227, Length=298, Percent_Identity=27.5167785234899, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI20129969, Length=342, Percent_Identity=26.6081871345029, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922386, Length=346, Percent_Identity=26.878612716763, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355645, Length=343, Percent_Identity=25.0728862973761, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24662223, Length=343, Percent_Identity=25.0728862973761, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI20129963, Length=382, Percent_Identity=26.7015706806283, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646701, Length=173, Percent_Identity=35.8381502890173, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=173, Percent_Identity=35.8381502890173, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=173, Percent_Identity=35.8381502890173, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49893; Mature: 49893

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADG
CCCEEEHHHCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCC
VIEKAFIGSGTGNQESALANAALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQ
CEEHHEECCCCCCCHHHHHCEEEEECCCCCCHHHHHCCCCCEEEEHHHHHHHHHHHEECC
PRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESLAHVVEELAKTHKAYFKQWIG
CEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELIKDNFPAIHAVGRASALTPRLLSLQWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
HHHHHCCCCCEECCCCHHCCCCEEEEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCH
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEI
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCCCCCCEEEECCCEEEEE
ENTDAEGRLILADALVKACEEKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVA
ECCCCCCCEEHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGAITAGLFLQRFVTKSIPWVHF
HCCCCCCCEEECCCCCHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADG
CCCEEEHHHCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCC
VIEKAFIGSGTGNQESALANAALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQ
CEEHHEECCCCCCCHHHHHCEEEEECCCCCCHHHHHCCCCCEEEEHHHHHHHHHHHEECC
PRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESLAHVVEELAKTHKAYFKQWIG
CEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELIKDNFPAIHAVGRASALTPRLLSLQWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
HHHHHCCCCCEECCCCHHCCCCEEEEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCH
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEI
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCCCCCCEEEECCCEEEEE
ENTDAEGRLILADALVKACEEKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVA
ECCCCCCCEEHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGAITAGLFLQRFVTKSIPWVHF
HCCCCCCCEEECCCCCHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA