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The map label for this gene is lpxC

Identifier: 52842814

GI number: 52842814

Start: 2943206

End: 2944120

Strand: Reverse

Name: lpxC

Synonym: lpg2608

Alternate gene names: 52842814

Gene position: 2944120-2943206 (Counterclockwise)

Preceding gene: 52842815

Following gene: 52842813

Centisome position: 86.65

GC content: 39.34

Gene sequence:

>915_bases
ATGATAAAACAAAGAACTCCTAAAAAGGTAATCCAGGCTACTGGTGTTGGATTACATTCCGGTGAGAAAGTGCTTTTAAC
CTTAAGACCAGCTCCTGTAAACACAGGTATCGTTTTTAGACGCGTCGATTTGTCACCAGTTGTCGAAATACCTGCCTCCT
ACGAATACGTCGGAGATACCATGCTTTGCACCACCCTTCATCATGGCAAGGTGAAAATTGCAACGGTGGAGCATTTATTA
TCCGCCCTGGCCGGGTTAGGAATTGATAACGCCTATATAGATGTCAATGCCCCAGAGATTCCAATTATGGATGGAAGTGC
CGCCCCATTTGTATTTTTAATTCAATCAGCGGGTATAAGAGAGCAAAATGCAGCAAAAAGATATATCCGAATTCTTAAAC
CTATACGAGTCGAAGAAAATGGAAAGTATGTTCAGTTCCTTCCTCATAAAGGATATAAAATAACATTTACCATAGGTTTT
GAGCACCCGGTTTTTAATGATAGACCACAAACAGTAAGCTTTGATTTTTCTGGAACATCGTATGTCAAAGAAGTTTGTAG
GGCGAGAACTTTTGGTTTTCTTTCAGATTATGAAAAATTGAGAGAGTGCGACCTGGCAAAAGGCGGTAGTCTAGATAATG
CTATTGTAGTAGATGATTATCGTGTCCTTAATGAAGATGGTCTCCGCTTCGAATCAGAATTTGTTACTCATAAAGTATTA
GATGCTATCGGTGATCTTTATTTATTGGGTTCCAGTTTAATTGGCGCATTTGAAGGATATAAATCTGGTCACGAATTAAA
CAACAGATTGTTGCGTGAATTAATGGTAAGGCAGGATGCTTGGGAATATACCTATTTTGATACAGAAAATTATCTGCCCG
CGGTTCACCCTGAATATTATCCTGTTGAAGCCTGA

Upstream 100 bases:

>100_bases
TTAATTGAAATTAAAAAAATTAGACTAATCAATAAATTGTTGCTAAGATCTTAAGGTTTTTGCGTGCAAAATAAATATAA
GAGAGAAAGGTGAGCACTGA

Downstream 100 bases:

>100_bases
CAGAAATACATCATATCCACGTAGTGAGAATATTCATTTTCACTATTATCATTTTATAGGCATTATCTATACTAAATATA
ATGGCCTAAGCAGTTTCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDTMLCTTLHHGKVKIATVEHLL
SALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIREQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGF
EHPVFNDRPQTVSFDFSGTSYVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMVRQDAWEYTYFDTENYLPAVHPEYYPVEA

Sequences:

>Translated_304_residues
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDTMLCTTLHHGKVKIATVEHLL
SALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIREQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGF
EHPVFNDRPQTVSFDFSGTSYVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMVRQDAWEYTYFDTENYLPAVHPEYYPVEA
>Mature_304_residues
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDTMLCTTLHHGKVKIATVEHLL
SALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIREQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGF
EHPVFNDRPQTVSFDFSGTSYVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMVRQDAWEYTYFDTENYLPAVHPEYYPVEA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=294, Percent_Identity=58.5034013605442, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_LEGPA (Q5X1T2)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_124966.1
- HSSP:   O67648
- ProteinModelPortal:   Q5X1T2
- SMR:   Q5X1T2
- STRING:   Q5X1T2
- GeneID:   3119267
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp2661
- LegioList:   lpp2661
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   LPNE297246:LPP2661-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.- [C]

Molecular weight: Translated: 34153; Mature: 34153

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDT
CCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCHHHCCE
MLCTTLHHGKVKIATVEHLLSALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIR
EEEEEEECCEEEEHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCEEEEEECCCCC
EQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGFEHPVFNDRPQTVSFDFSGTS
CHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEECCCHH
YVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEECCCCCEEHHHHHHHHHH
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMVRQDAWEYTYFDTENYLPAVHPEYY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
PVEA
CCCC
>Mature Secondary Structure
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDT
CCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCHHHCCE
MLCTTLHHGKVKIATVEHLLSALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIR
EEEEEEECCEEEEHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCEEEEEECCCCC
EQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGFEHPVFNDRPQTVSFDFSGTS
CHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEECCCHH
YVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEECCCCCEEHHHHHHHHHH
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMVRQDAWEYTYFDTENYLPAVHPEYY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
PVEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA