Click here to switch to the map view.

The map label for this gene is pdhB [H]

Identifier: 52842787

GI number: 52842787

Start: 2908957

End: 2911227

Strand: Reverse

Name: pdhB [H]

Synonym: lpg2581

Alternate gene names: 52842787

Gene position: 2911227-2908957 (Counterclockwise)

Preceding gene: 52842794

Following gene: 52842786

Centisome position: 85.68

GC content: 42.84

Gene sequence:

>2271_bases
CTGGTCATTGCGCAATTTAAACAGGGTGTGGTGATGTTAGATAGAGCAAGTGTAGTGGATGAACAATTTCTGAAAAGAGT
GTTGCAAGGGGATTTCCCACAATTAAGAAGCAGCATGAGCCCCGATACAGCAGAGTTGGACAAGAAAACTGCTATAGAAT
TTTTTGACTCACAAATTAAATCCCGGCTTCTTGATATTATTGCGAGACAATTAAAGGAAAAAGGCCTCTCTTTTTATACG
ATAGGAAGTAGTGGTCATGAAGGCAATGCGGTTTTGGGTCAGGTTTTTAGAGCGAGTGATATGGCGTTTTTGCACTATCG
CAGCGGTGCCTTTTTCTTGCAACGAGCAAAGCAATTACCTGGAATCGATGGAGTAAAGGATATTTTATTGTCATTAGTGG
CTGCGGCAAGTGATCCTATCTCAGGGGGCAGGCATAAAGTCTTTGGCAGCGTCCCTTTAAATATCCCGCCGCAAACATCG
ACTATCGCATCTCATTTACCAAAAGCTTTAGGCGCTGCTTTATCAATTACCAGAGCGCGAGAGTTAGGATTGCCAAGTAA
ACTGACGCCTGATTCCGTGATACTTTGTTCCTTTGGTGATGCTTCAACCAACCATGCAACGAGCCAAGCCACATTGAATG
CTTGCTCCTGGATAACCCAGCAAAACTATCCACTCCCCATTGTGTTCATTTGTGAAGATAATGGAATCGGTATTTCAGTA
CCTACTCCATCCAGTTGGATTAAGTCATCCGTTTCTTCTCGTCCAGGAATACATTACATTGAGTGTGATGGATTAAACAT
TGCGGATGTTTTTGCCAAAGCGCAGGAAGCGGACTATTTGGCAAGAGTAAAAAAACAACCCGTGTTCTTGCACATGCGTT
GTGTCCGTTTGTTGGGCCATGCCGGTTCTGATATTGAATCGCAATACAACACTCAGGAAGAAATTGAGCAACGAGAAGCA
AACGACCCTTTATTGCATACAGCAGGAATTTTGTACAGAGAAGGTTGGATGAGTTTACAGGCAATGGTTGAGCTTTATCA
GGACAACCGGGCTTTAATTGAAGCCAAGGCACTCGAGGCAATCAGAGAACCCAGAATGAGTTCTGCTGAAGAAATAATGG
CTTCAATTGTCCCACGAATTGATAAAAAGCAAAAATACTCATTGCCAGATGATAATAGGCGAGCGCAAGTATTTGCCGGA
GCTTATAATCAACTCACCCTAAAGCGTAATTTATGCCAGCAGATCAATTTTGCCTTGACCGATCTGATGATGCAGTATCC
TAATATGTTGATTTTTGGAGAAGACGTAGGAAAGAAAGGTGGAGTTTATCGAGTTACAGCTGATTTACAGGCTCGTTTTG
GGCAACGCAGGGTTTTTGATACCCTTCTCGATGAAACGACCATTATAGGTACTGCTATTGGTTTGGCACATAATGGCTTT
ATTCCTGTTCCGGAAATTCAGTTCTTAGCTTATCTGCATAATGCCGAAGATCAATTACGTGGAGAAGCATCCACTTTATC
TTTTTTTTCAAGTGGCCAATATCAAAACCCTATGGTACTTCGAATCGCCTCTCTTGCTTATCAGAAGGGATTTGGCGGTC
ATTTTCATAACGATAATTCGATAGCCGTTTTACGCGATTTGCCAGGGGTTATAGTGGCTTGCCCCTCTAATGGCCCGGAC
GCAGCAAAAATGTTGAGAACATGTATGCGCCTTGCCTATGAGGAAGGGCGGGTTGTCGTGTTTTTAGAGCCCATTGCCCT
CTACATGACCAAGGATTTGTATAGCCCGGGAGATAATGGGTGGTTATTTGAATACCCGTCACCTGATGAAATGATTTCTC
AAGGAGAGGTTGGCGTATATGGGGAGGGGGATACTGTTATTTTAACATATGCCAATGGATATTATTTATCTCGCCAGGCG
GAAAAGGTCTTGCGTGAAGCACATAATATTTCTGTTAAGATCATTGATTTGCGCTGGCTCAGCCCCTTGCCAAAAGACGC
CATTTTAAAAGAAATTGCCAAGGCAAAACGTATTTTAATTGTTGATGAGGGTAGACAAAGCGGCTCAATTAGTGAAGGAT
TGATGACATTATTGATGGAAGAGGCTTCGCCACGGTTAAAAATAAAGCGGATTACGGGCAAAGATTGCTTCATACCATTA
GGAACTGCTTGGCAGTATTTATTGCCAAGTCAGGAAAGTATTATAGACGCGGTAATCGCATTACAGTCAGATAAAAGGGA
GAAGGAAAGTGGACGACTTGTTGTTTCTTGA

Upstream 100 bases:

>100_bases
GCAGAATTATGAATTTCTTTATAGTTCGTTGGGAAAGGATACCAGGCATGGATATAAGAGTAATCATTACACAAAATGTA
ATTGAAATAGCCTTATTCAT

Downstream 100 bases:

>100_bases
TGAACAATTACATGATGACGAGCGCATGATACGAGATAGTGTGTCTCGTTTTGTTAGCAATGACGTAATACCTTTAATGG
CTGAATCTTATGAGCACGCC

Product: 2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MVIAQFKQGVVMLDRASVVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQLKEKGLSFYT
IGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTS
TIASHLPKALGAALSITRARELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISV
PTPSSWIKSSVSSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNTQEEIEQREA
NDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAG
AYNQLTLKRNLCQQINFALTDLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGF
IPVPEIQFLAYLHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVIVACPSNGPD
AAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYSPGDNGWLFEYPSPDEMISQGEVGVYGEGDTVILTYANGYYLSRQA
EKVLREAHNISVKIIDLRWLSPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPL
GTAWQYLLPSQESIIDAVIALQSDKREKESGRLVVS

Sequences:

>Translated_756_residues
MVIAQFKQGVVMLDRASVVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQLKEKGLSFYT
IGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTS
TIASHLPKALGAALSITRARELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISV
PTPSSWIKSSVSSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNTQEEIEQREA
NDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAG
AYNQLTLKRNLCQQINFALTDLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGF
IPVPEIQFLAYLHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVIVACPSNGPD
AAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYSPGDNGWLFEYPSPDEMISQGEVGVYGEGDTVILTYANGYYLSRQA
EKVLREAHNISVKIIDLRWLSPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPL
GTAWQYLLPSQESIIDAVIALQSDKREKESGRLVVS
>Mature_756_residues
MVIAQFKQGVVMLDRASVVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQLKEKGLSFYT
IGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTS
TIASHLPKALGAALSITRARELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISV
PTPSSWIKSSVSSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNTQEEIEQREA
NDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAG
AYNQLTLKRNLCQQINFALTDLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGF
IPVPEIQFLAYLHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVIVACPSNGPD
AAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYSPGDNGWLFEYPSPDEMISQGEVGVYGEGDTVILTYANGYYLSRQA
EKVLREAHNISVKIIDLRWLSPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPL
GTAWQYLLPSQESIIDAVIALQSDKREKESGRLVVS

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=320, Percent_Identity=31.875, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI34101272, Length=320, Percent_Identity=31.875, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI156564403, Length=335, Percent_Identity=23.5820895522388, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI258645172, Length=328, Percent_Identity=22.2560975609756, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI11386135, Length=329, Percent_Identity=22.1884498480243, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI291084858, Length=336, Percent_Identity=22.0238095238095, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=354, Percent_Identity=27.4011299435028, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17506935, Length=346, Percent_Identity=28.0346820809249, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86563357, Length=353, Percent_Identity=22.0963172804533, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI86563355, Length=353, Percent_Identity=22.0963172804533, Blast_Score=94, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319698, Length=331, Percent_Identity=27.4924471299094, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI160714832, Length=338, Percent_Identity=26.6272189349112, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI160714828, Length=338, Percent_Identity=26.6272189349112, Blast_Score=106, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21358145, Length=356, Percent_Identity=24.7191011235955, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650940, Length=356, Percent_Identity=24.7191011235955, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355903, Length=322, Percent_Identity=21.4285714285714, Blast_Score=78, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 83659; Mature: 83659

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIAQFKQGVVMLDRASVVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIK
CEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SRLLDIIARQLKEKGLSFYTIGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLP
HHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHCC
GIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALGAALSITRAR
CCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISV
HCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEC
PTPSSWIKSSVSSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGH
CCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
AGSDIESQYNTQEEIEQREANDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEA
CCCCHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNLCQQINFALT
HHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
DLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGF
HHHHHCCCEEEEECCCCCCCCEEEEEEHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCC
IPVPEIQFLAYLHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNS
CCCCHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
IAVLRDLPGVIVACPSNGPDAAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYSPGDNG
EEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCC
WLFEYPSPDEMISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLREAHNISVKIIDLRWL
EEEECCCHHHHHCCCCEEEEECCCEEEEEECCCEEEHHHHHHHHHHHHCCEEEEEEEEEC
SPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPL
CCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEC
GTAWQYLLPSQESIIDAVIALQSDKREKESGRLVVS
CCHHHHHCCCHHHHHHHHHHHHCCCCHHHCCCEEEC
>Mature Secondary Structure
MVIAQFKQGVVMLDRASVVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIK
CEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SRLLDIIARQLKEKGLSFYTIGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLP
HHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHCC
GIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALGAALSITRAR
CCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISV
HCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEC
PTPSSWIKSSVSSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGH
CCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
AGSDIESQYNTQEEIEQREANDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEA
CCCCHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNLCQQINFALT
HHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
DLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGF
HHHHHCCCEEEEECCCCCCCCEEEEEEHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCC
IPVPEIQFLAYLHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNS
CCCCHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
IAVLRDLPGVIVACPSNGPDAAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYSPGDNG
EEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCC
WLFEYPSPDEMISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLREAHNISVKIIDLRWL
EEEECCCHHHHHCCCCEEEEECCCEEEEEECCCEEEHHHHHHHHHHHHCCEEEEEEEEEC
SPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPL
CCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEC
GTAWQYLLPSQESIIDAVIALQSDKREKESGRLVVS
CCHHHHHCCCHHHHHHHHHHHHCCCCHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]