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The map label for this gene is bepF [H]

Identifier: 52842721

GI number: 52842721

Start: 2840592

End: 2841758

Strand: Reverse

Name: bepF [H]

Synonym: lpg2513

Alternate gene names: 52842721

Gene position: 2841758-2840592 (Counterclockwise)

Preceding gene: 52842722

Following gene: 52842720

Centisome position: 83.64

GC content: 41.65

Gene sequence:

>1167_bases
CTGGTGATGAGAATGAACTCTCAAAATAAACAAAATTTAGTTAAAACCGTAGCAATTGTATTTTTTGGTATTGTGTTTGT
TTATTTAGTATATGACCATTTTACAAGGGCCCAGGTAGCAACCCCAGCACCGCCAGATGTGATCGTTCAAAAGCCCAAAT
TAATGAAAATGGGACAGTATGTTACCCAGACAGGTAATACAGTAGCATTTCAATCGGTAGATTTGGTGGCACGGATTGAA
GGTTATTTGGATGCCATAAAATTTACTGACGGCGCTTTTGTCAAAAAAAATCAGGAATTATTTATTATTGAACCCGAGCC
CTATCTTGAGCAACTGCGTGCTGCTGAAGCCAAGGTAGCCGCTCAAAAAGCAAATTATGCCTATGCCAAATCAGAGTATG
CCAGACAGCAACGCATGTATAAACAAAATGCCACGTCTCTTAACAGTGTTGAAAAATGGAAAGCAAAAGTTGAAGAAGCA
CAGGCAGAAGTAGATAAATCGGAAGCTGATGCTACAAACGCCGCAATTACATATGGTTATACCCACGTTTCAGCTCCTTT
CGATGGGCGGATGGGAAGACATTTAGTCGATGTGGGTAATTTGGTTGGGCACGGTGCCGCAACGGATTTGGCTACCATAG
AACAAATCGACCCTATTTACGTTTATTTTAATTTAAATGAACTGGATTTAATCAGGATTAGAAATGCAGCGCGCAAGAGA
GGATATAAACCAATGGAATTGGTCAAAATCCCTGTTGAAGTGGCTTTGCAAGATGAAAAAGGATTTCCTCATAAGGGGAC
ATTGGATTTTGTAAATACTGGTTTAAACGCTTCAACTGGAACCATGGAGTTTCGCGCCTTGTTACCTAACAAGGGATATC
CCCTGGTACCTGGTTTATTTGTGCAAGTCCGGGTACCGATATCTGAACCTTCTCCAAAATTAACAATACCTGACACCTCT
GTTCAATACGATCAAATTGGCCCCTATGTCCTTGTGGTTGATAAAGACAATTATGTGCTTACCAAACGCGTGACACTTGG
CGGGCTAGAAAATGGGGTAAGGGCTATTACTAAAGGCCTTGATGCTCAAGACAGTGTGATTGTTTCCGGGTTGCAAAATG
CGACGCCCAATCATCGGGTTACGCCTAAAACTGAGCAACCTGAGTAA

Upstream 100 bases:

>100_bases
AAATGGCTGCCCGTACTAATTGGGGTAGTTTATTGAAGCAAGAAAATCATTTGCCTCCAGACTCTAACGGACAACGAATG
AAACAACTATATTTACCAAC

Downstream 100 bases:

>100_bases
GTATGGCCAAAAAATTGTAAGAATTTAAGACCCTTTATTCAGGGAGCGAAACAACTGAAATGATTTCCAAATTTTTTATT
GAAAGACCCGTTCTGGCCAA

Product: RND multidrug efflux membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MVMRMNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRAQVATPAPPDVIVQKPKLMKMGQYVTQTGNTVAFQSVDLVARIE
GYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEA
QAEVDKSEADATNAAITYGYTHVSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIRIRNAARKR
GYKPMELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVRVPISEPSPKLTIPDTS
VQYDQIGPYVLVVDKDNYVLTKRVTLGGLENGVRAITKGLDAQDSVIVSGLQNATPNHRVTPKTEQPE

Sequences:

>Translated_388_residues
MVMRMNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRAQVATPAPPDVIVQKPKLMKMGQYVTQTGNTVAFQSVDLVARIE
GYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEA
QAEVDKSEADATNAAITYGYTHVSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIRIRNAARKR
GYKPMELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVRVPISEPSPKLTIPDTS
VQYDQIGPYVLVVDKDNYVLTKRVTLGGLENGVRAITKGLDAQDSVIVSGLQNATPNHRVTPKTEQPE
>Mature_388_residues
MVMRMNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRAQVATPAPPDVIVQKPKLMKMGQYVTQTGNTVAFQSVDLVARIE
GYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEA
QAEVDKSEADATNAAITYGYTHVSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIRIRNAARKR
GYKPMELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVRVPISEPSPKLTIPDTS
VQYDQIGPYVLVVDKDNYVLTKRVTLGGLENGVRAITKGLDAQDSVIVSGLQNATPNHRVTPKTEQPE

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=338, Percent_Identity=29.8816568047337, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789929, Length=313, Percent_Identity=28.4345047923323, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI87082036, Length=322, Percent_Identity=29.1925465838509, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786668, Length=317, Percent_Identity=29.6529968454259, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87081796, Length=387, Percent_Identity=23.5142118863049, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43069; Mature: 43069

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMRMNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRAQVATPAPPDVIVQKPKLMKMGQY
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHEECCCHHHHHHHH
VTQTGNTVAFQSVDLVARIEGYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVA
HHHCCCEEEEEHHHHHHHHHHHHHHHEECCCCEEECCCCEEEECCCHHHHHHHHHHHHHH
AQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEVDKSEADATNAAITYGY
HHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEECE
THVSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIRIRNAARKR
EEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHC
GYKPMELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLF
CCCCHHEEEECEEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEE
VQVRVPISEPSPKLTIPDTSVQYDQIGPYVLVVDKDNYVLTKRVTLGGLENGVRAITKGL
EEEEEECCCCCCEEECCCCCCCHHCCCCEEEEEECCCEEEEEEEEECCHHHHHHHHHHCC
DAQDSVIVSGLQNATPNHRVTPKTEQPE
CCCCHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVMRMNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRAQVATPAPPDVIVQKPKLMKMGQY
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHEECCCHHHHHHHH
VTQTGNTVAFQSVDLVARIEGYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVA
HHHCCCEEEEEHHHHHHHHHHHHHHHEECCCCEEECCCCEEEECCCHHHHHHHHHHHHHH
AQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEVDKSEADATNAAITYGY
HHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEECE
THVSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIRIRNAARKR
EEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHC
GYKPMELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLF
CCCCHHEEEECEEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEE
VQVRVPISEPSPKLTIPDTSVQYDQIGPYVLVVDKDNYVLTKRVTLGGLENGVRAITKGL
EEEEEECCCCCCEEECCCCCCCHHCCCCEEEEEECCCEEEEEEEEECCHHHHHHHHHHCC
DAQDSVIVSGLQNATPNHRVTPKTEQPE
CCCCHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]