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The map label for this gene is iscS [H]

Identifier: 39997879

GI number: 39997879

Start: 3064891

End: 3066027

Strand: Reverse

Name: iscS [H]

Synonym: GSU2786

Alternate gene names: 39997879

Gene position: 3066027-3064891 (Counterclockwise)

Preceding gene: 39997882

Following gene: 39997878

Centisome position: 80.39

GC content: 70.36

Gene sequence:

>1137_bases
ATGACCGTCTACCTGGACTGTAATGCCACGACCCCCCTGGAGCCGGCCGTCATGGCCGTGGTGACCCGCTTCATGGAGCG
GGATTACGGCAACGCGGCGAGCCCCATTCATGATTTCGGAGTGTTCGCGCGGCTGGCGGTTGAGCATGCCCGGGGCCAGG
TGGCTGAGGTGGCGGCTGCCCGGCGGGACGAGGTGATCTTCACCAGCGGGGCTACCGAGGCCGACAACCTGGCGCTCCTG
GGCCTGGCGGACCACGGCCTGGCATGCGGGCGACGTCATGTGATCAGCACGGCCGTCGAGCACAAGGCGGTGCTCGAACC
GCTGGAAGAGCTGGCGCGCCGCGGATTCCAGGTGGAGCTCCTCCCCGTGGGGGCGTCGGGGCGGCTGGACCCTGACCGGC
TGCGTGCGGCGCTCCGGCCTGACACCCTTCTCGTTTCCACCATGCACGTCAACAACGAAACCGGCGTGGTCCAGCCCCTG
GCCGAACTGGCTGAGATCCTGGCCGGCCACGGCGCCTACTGGCACGTGGACGCGGCCCAGGGCTTCGGCAAGGAGATCGA
CGGTCTGCGCAATCCGCGGATCGACCTGATCGCCGTGAGCGGCCACAAGATCTACGCCCCCAAGGGGGTGGGCGCCCTCA
TCGCCCGCAAGCGGGACCGCGCCTTTCCGCCGCTGCGGCCCCTGATGCTGGGCGGCGGCCAGGAGCAGGGGCTGCGGCCC
GGAACCCTGCCCGTCCCCCTCATTGCCGGTTTCGGCGAGGCAGCCAAGCTGGCGGTGCGCACCCACGAGGCGCGCTCCGC
CGCCAACCGCGCCTTCCGGGAAAAACTCCTGGCCGCCCTGGCCCCACTGGAGCCGACCCTCAACGGCGACCAGGAGCACG
TCCTTCCCCATGCCGTGAACCTTTCCCTGGCCGGGATCGAGGCCGACCGGGCCATCACCGCCCTCAAGGGGGTCATTGCC
GTGTCGAGCACCTCGGCCTGCACCTCCCACACCCGGGCGCCGAGCCACGTTCTCACCGCCATGGGGCTTTCCCCGGAGCG
GGTCGAGACGTCGCTGCGGCTTTCCTGGTGCCACCTGACCCCGGCCGTGGACTGGGACGAGGTCGTCTCCATCCTGCGCG
GACTCCGCGCATCATGA

Upstream 100 bases:

>100_bases
ATAATCTATTGTATTTATCGAGTTCTCTTGCCTACTATCAGCACAGGGGCAAGAGCAGTGGCTCCGCGTCCCCACTCACC
GTTCGGAGCGGGAGGATTGT

Downstream 100 bases:

>100_bases
CGAGGAGGTTTCAATGACCGTTTTCGAAGAACTGGAACAGGCAACGCTCGCCCAGTTCGAGCAGGGCGAGCTCCCCCACT
GGCTGGCCGACCCGGCCCTG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTVYLDCNATTPLEPAVMAVVTRFMERDYGNAASPIHDFGVFARLAVEHARGQVAEVAAARRDEVIFTSGATEADNLALL
GLADHGLACGRRHVISTAVEHKAVLEPLEELARRGFQVELLPVGASGRLDPDRLRAALRPDTLLVSTMHVNNETGVVQPL
AELAEILAGHGAYWHVDAAQGFGKEIDGLRNPRIDLIAVSGHKIYAPKGVGALIARKRDRAFPPLRPLMLGGGQEQGLRP
GTLPVPLIAGFGEAAKLAVRTHEARSAANRAFREKLLAALAPLEPTLNGDQEHVLPHAVNLSLAGIEADRAITALKGVIA
VSSTSACTSHTRAPSHVLTAMGLSPERVETSLRLSWCHLTPAVDWDEVVSILRGLRAS

Sequences:

>Translated_378_residues
MTVYLDCNATTPLEPAVMAVVTRFMERDYGNAASPIHDFGVFARLAVEHARGQVAEVAAARRDEVIFTSGATEADNLALL
GLADHGLACGRRHVISTAVEHKAVLEPLEELARRGFQVELLPVGASGRLDPDRLRAALRPDTLLVSTMHVNNETGVVQPL
AELAEILAGHGAYWHVDAAQGFGKEIDGLRNPRIDLIAVSGHKIYAPKGVGALIARKRDRAFPPLRPLMLGGGQEQGLRP
GTLPVPLIAGFGEAAKLAVRTHEARSAANRAFREKLLAALAPLEPTLNGDQEHVLPHAVNLSLAGIEADRAITALKGVIA
VSSTSACTSHTRAPSHVLTAMGLSPERVETSLRLSWCHLTPAVDWDEVVSILRGLRAS
>Mature_377_residues
TVYLDCNATTPLEPAVMAVVTRFMERDYGNAASPIHDFGVFARLAVEHARGQVAEVAAARRDEVIFTSGATEADNLALLG
LADHGLACGRRHVISTAVEHKAVLEPLEELARRGFQVELLPVGASGRLDPDRLRAALRPDTLLVSTMHVNNETGVVQPLA
ELAEILAGHGAYWHVDAAQGFGKEIDGLRNPRIDLIAVSGHKIYAPKGVGALIARKRDRAFPPLRPLMLGGGQEQGLRPG
TLPVPLIAGFGEAAKLAVRTHEARSAANRAFREKLLAALAPLEPTLNGDQEHVLPHAVNLSLAGIEADRAITALKGVIAV
SSTSACTSHTRAPSHVLTAMGLSPERVETSLRLSWCHLTPAVDWDEVVSILRGLRAS

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=369, Percent_Identity=42.2764227642276, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI156713448, Length=409, Percent_Identity=34.4743276283619, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI48994898, Length=374, Percent_Identity=43.5828877005348, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1787970, Length=216, Percent_Identity=29.1666666666667, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789175, Length=238, Percent_Identity=31.5126050420168, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25143064, Length=360, Percent_Identity=41.3888888888889, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17533177, Length=321, Percent_Identity=29.9065420560748, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319831, Length=368, Percent_Identity=42.9347826086957, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI20129463, Length=366, Percent_Identity=41.5300546448087, Blast_Score=258, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40337; Mature: 40206

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYLDCNATTPLEPAVMAVVTRFMERDYGNAASPIHDFGVFARLAVEHARGQVAEVAAA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
RRDEVIFTSGATEADNLALLGLADHGLACGRRHVISTAVEHKAVLEPLEELARRGFQVEL
CCCCEEEECCCCCCCCEEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
LPVGASGRLDPDRLRAALRPDTLLVSTMHVNNETGVVQPLAELAEILAGHGAYWHVDAAQ
EEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHH
GFGKEIDGLRNPRIDLIAVSGHKIYAPKGVGALIARKRDRAFPPLRPLMLGGGQEQGLRP
CCCHHHHCCCCCCEEEEEECCCEEECCCCCHHHHHHHCCCCCCCCCHHEECCCCCCCCCC
GTLPVPLIAGFGEAAKLAVRTHEARSAANRAFREKLLAALAPLEPTLNGDQEHVLPHAVN
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCEEEE
LSLAGIEADRAITALKGVIAVSSTSACTSHTRAPSHVLTAMGLSPERVETSLRLSWCHLT
EEEECCCHHHHHHHHHHHHEECCCCHHHHCCCCCHHHHHHCCCCHHHHHHEEEEEEEECC
PAVDWDEVVSILRGLRAS
CCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVYLDCNATTPLEPAVMAVVTRFMERDYGNAASPIHDFGVFARLAVEHARGQVAEVAAA
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
RRDEVIFTSGATEADNLALLGLADHGLACGRRHVISTAVEHKAVLEPLEELARRGFQVEL
CCCCEEEECCCCCCCCEEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
LPVGASGRLDPDRLRAALRPDTLLVSTMHVNNETGVVQPLAELAEILAGHGAYWHVDAAQ
EEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHH
GFGKEIDGLRNPRIDLIAVSGHKIYAPKGVGALIARKRDRAFPPLRPLMLGGGQEQGLRP
CCCHHHHCCCCCCEEEEEECCCEEECCCCCHHHHHHHCCCCCCCCCHHEECCCCCCCCCC
GTLPVPLIAGFGEAAKLAVRTHEARSAANRAFREKLLAALAPLEPTLNGDQEHVLPHAVN
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCEEEE
LSLAGIEADRAITALKGVIAVSSTSACTSHTRAPSHVLTAMGLSPERVETSLRLSWCHLT
EEEECCCHHHHHHHHHHHHEECCCCHHHHCCCCCHHHHHHCCCCHHHHHHEEEEEEEECC
PAVDWDEVVSILRGLRAS
CCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA