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The map label for this gene is mcpA [H]

Identifier: 39997518

GI number: 39997518

Start: 2655025

End: 2656626

Strand: Direct

Name: mcpA [H]

Synonym: GSU2423

Alternate gene names: 39997518

Gene position: 2655025-2656626 (Clockwise)

Preceding gene: 39997517

Following gene: 39997519

Centisome position: 69.61

GC content: 64.73

Gene sequence:

>1602_bases
ATGAAGAAATCAGGCGCCAAACCAGCGGAAATGACCCTGCACCGTGAAATCCAGCGACTCGCCGAGGCCATGATGAACGG
GAGGCTCGACGAACGGGGGGACCCTGCGCAGTTCACCGGCGACGATGCCGCACTGGTTCTCATGGTCAACCGGATGCTGG
ACACGCTGGTGACGCCGCTCCGCCTGGCCGCCGGCGCCATCGACGAGATCGCCCACGGCAGGATCCCTCCCTTTGTCATC
GACGACTACACCGGGGAGTACAACAACCTCAAGCGCAACCTCAACACCCTCCTGGCCACCCTCTACGGCCTCCACAGCGA
GACCCAGCACCTGGTCGGCAACATCGGTGAGGGAAGGCTCCAGACCCGGGGCAACGACTGGGATTTCGAGGGGATCTGGC
GCGATCTGATCAAGGGGGTGAACGGAACCCTCGACGCGGTCATCGACCCGGTGAACGAGGCGGGGACCGTGCTCCGCCAC
CTGGCCGAGTACGACCTGAGCGCCCGGATGCGGGGGAAATACCACGGCGAGCACGCCGCCATCAAGAAGGCCATGAACTC
GACGGCGGAATCGCTCCACTCGGCCGTGACCCAGATGACCGAAACGGTGGAACTGGTCTCGGCCGTCGGCGGGCAGATCG
CCGACAGCAGCCAGCTGGTGACCCAGGGGGCCCGGGAGCAGGAGGCCCAGCTGACCGAGACCTCCAACGTGCTCGATCAC
ATCGCCGCCACCTCCCAGAAGAGCGCCCGGAGCACCATTGACGCCCGCCAGGCCGCCGGCGGCTCCGCCGAGTCCATCAA
AACGGCCAAGTCGGTCATGGACCAGATGCTCCAGGCCATGGGGCAGATCCGGAGCGCGGCGGACAACACCGTGGGTATTG
TCCAGCAGATCGACTCCATTGCCAAGGAAACCGACCAGCTCTCTTCCAACGCCACCAGCAAGGCAACCCTGATCCGTTCC
TCCGCCAACGGCTTCAGCGTGGTTGCCTCGGAAATCAGGAACCTGTCGAAACGGTGCGAGGACGCCGTGACACGGCTCCA
CGACTTCCGGCGCCGGGCTACCCTGACCCCCAATGGGGGGAGCGGAGACACGGACGATGCGCTCGAATGCGAGTACCTGG
AACTGATTCACGAGTTGAAGAGCGTGGCCTCCAGCTCAGGCCTGCTGGGAGTGAACGCAGCGATCTCGGCGGCCCACGTG
GAAGGTGCCGGCAACGACTTCCAGGTGCTGACCGAGGAGATCCGCCAACTGGCCAAGCGTTCCACCGATGCGGCGCGGCA
GACCGACACGCTCATCAAGACATCGGTCGAGCAGGCCCGGCGGGGAGAGGACCTGTCCCGCAAGATCGACGTCCACCTCA
CCGAGGCGGTAACCGGGGCAACGACGATCTGCGCCCTGACCGAGGACATCTCCCAGAGCAGCCAGGAACAGGCGAGCGCC
ATCGAGCAGATCAGCCGCTCCGTCAACCACATCACCACCATCACCAGGCAGAACGCGGACAGCGCGCTCAAGTCGTCGGA
AGTATCGCACAAACTCGGCCAGCAGATGACCAAGCTCACCAGCATGGTGAGCAAGTTCAGGCTGGACAACGCCGCCTGCT
GA

Upstream 100 bases:

>100_bases
CGGACCCGCGACGCCATGTCGCCGGAGGTGGCATCAGCCATAGAACCGGCCGTCGCCCTGATCCGCAACTACCTCCATAC
TCTTGGACAAGGAATCTGAC

Downstream 100 bases:

>100_bases
ACCTGGTTTCGCCACGCCGCAATCCTGGCAGGCCCCCATCCGGAGCGACATGATGGGGGCCTCTTTTTATATAGCGACCT
GAATTCGTGAGGGCTGACGC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKKSGAKPAEMTLHREIQRLAEAMMNGRLDERGDPAQFTGDDAALVLMVNRMLDTLVTPLRLAAGAIDEIAHGRIPPFVI
DDYTGEYNNLKRNLNTLLATLYGLHSETQHLVGNIGEGRLQTRGNDWDFEGIWRDLIKGVNGTLDAVIDPVNEAGTVLRH
LAEYDLSARMRGKYHGEHAAIKKAMNSTAESLHSAVTQMTETVELVSAVGGQIADSSQLVTQGAREQEAQLTETSNVLDH
IAATSQKSARSTIDARQAAGGSAESIKTAKSVMDQMLQAMGQIRSAADNTVGIVQQIDSIAKETDQLSSNATSKATLIRS
SANGFSVVASEIRNLSKRCEDAVTRLHDFRRRATLTPNGGSGDTDDALECEYLELIHELKSVASSSGLLGVNAAISAAHV
EGAGNDFQVLTEEIRQLAKRSTDAARQTDTLIKTSVEQARRGEDLSRKIDVHLTEAVTGATTICALTEDISQSSQEQASA
IEQISRSVNHITTITRQNADSALKSSEVSHKLGQQMTKLTSMVSKFRLDNAAC

Sequences:

>Translated_533_residues
MKKSGAKPAEMTLHREIQRLAEAMMNGRLDERGDPAQFTGDDAALVLMVNRMLDTLVTPLRLAAGAIDEIAHGRIPPFVI
DDYTGEYNNLKRNLNTLLATLYGLHSETQHLVGNIGEGRLQTRGNDWDFEGIWRDLIKGVNGTLDAVIDPVNEAGTVLRH
LAEYDLSARMRGKYHGEHAAIKKAMNSTAESLHSAVTQMTETVELVSAVGGQIADSSQLVTQGAREQEAQLTETSNVLDH
IAATSQKSARSTIDARQAAGGSAESIKTAKSVMDQMLQAMGQIRSAADNTVGIVQQIDSIAKETDQLSSNATSKATLIRS
SANGFSVVASEIRNLSKRCEDAVTRLHDFRRRATLTPNGGSGDTDDALECEYLELIHELKSVASSSGLLGVNAAISAAHV
EGAGNDFQVLTEEIRQLAKRSTDAARQTDTLIKTSVEQARRGEDLSRKIDVHLTEAVTGATTICALTEDISQSSQEQASA
IEQISRSVNHITTITRQNADSALKSSEVSHKLGQQMTKLTSMVSKFRLDNAAC
>Mature_533_residues
MKKSGAKPAEMTLHREIQRLAEAMMNGRLDERGDPAQFTGDDAALVLMVNRMLDTLVTPLRLAAGAIDEIAHGRIPPFVI
DDYTGEYNNLKRNLNTLLATLYGLHSETQHLVGNIGEGRLQTRGNDWDFEGIWRDLIKGVNGTLDAVIDPVNEAGTVLRH
LAEYDLSARMRGKYHGEHAAIKKAMNSTAESLHSAVTQMTETVELVSAVGGQIADSSQLVTQGAREQEAQLTETSNVLDH
IAATSQKSARSTIDARQAAGGSAESIKTAKSVMDQMLQAMGQIRSAADNTVGIVQQIDSIAKETDQLSSNATSKATLIRS
SANGFSVVASEIRNLSKRCEDAVTRLHDFRRRATLTPNGGSGDTDDALECEYLELIHELKSVASSSGLLGVNAAISAAHV
EGAGNDFQVLTEEIRQLAKRSTDAARQTDTLIKTSVEQARRGEDLSRKIDVHLTEAVTGATTICALTEDISQSSQEQASA
IEQISRSVNHITTITRQNADSALKSSEVSHKLGQQMTKLTSMVSKFRLDNAAC

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=156, Percent_Identity=29.4871794871795, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787690, Length=155, Percent_Identity=30.3225806451613, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI2367378, Length=155, Percent_Identity=30.9677419354839, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788195, Length=155, Percent_Identity=30.9677419354839, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789453, Length=146, Percent_Identity=28.0821917808219, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57503; Mature: 57503

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]