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The map label for this gene is yrkH [H]

Identifier: 39997407

GI number: 39997407

Start: 2526772

End: 2528190

Strand: Direct

Name: yrkH [H]

Synonym: GSU2309

Alternate gene names: 39997407

Gene position: 2526772-2528190 (Clockwise)

Preceding gene: 39997406

Following gene: 39997408

Centisome position: 66.25

GC content: 63.5

Gene sequence:

>1419_bases
GTGTTTATCCAGCAATTCTTCGTATCCGGCCTGGCACACAGCTCTTATTTGCTCGGCGGAACATCAACCTGCGCGATTGT
CGATCCCCGGCGCGATATTGAGATATACCTGGATGCGGCAGCGTCCATGGGAATGAAAATCACCCACATTCTCCAGACCC
ATCTCCATGCCGATTTTGTTTCGGGACATCTTGACCTGGCCGAGGCTACCGGCGCCGTCATAGTGGCTCCCAGGTCCGCA
GATTGTCAGTTCAGCCACCTGGACGTGGCAGAGGGGGACAGCTTCCGGATCGATGACCTGGAAATCCGGGTCCTGGAAAC
CCCCGGCCACACACCCGAGCATATTACCTACGTGGTCGTGGATCATGGCCGGGGCCCGGAACCGGCCGTAATTTTCTGTG
GCGACACTCTTTTCGTGGGGGATGTGGGACGCCCCGACCTTTTTCCGGGCATGGCCCTGGAGTTGGCCGCAAAACTATAT
GGTTCTCTCCATGAAAAGCTCATGGCGCTCCCCCCCTTCTGCGAGGTCTATCCGGCCCACGGCGCGGGTTCCCTCTGCGG
CAGGGCCATGGGGGCCAAGCGAACCAGCACCGTGGGGTACGAGAAGCTTTACAACGGCGCGCTCGCCATTGGCGACCGGC
AGCGGTTCATAACCTCACTCACTACGGACATGCCGGCCGCTCCGGACCATTTCTCCCGCTGCAGCGACATCAACCGCCGG
GGACCGGCACTGGTTCGGACCCTCCCGGTCCCCGCCCCGCTGCCCCCGCAACGTTTCCGTGAGGCTATGGCCGAGAGCGA
CACCGTGGTTCTCGATGTTCGGGGATACGCCGCCTTCGGAGGGCAGCACGTGCCTGGTTCCTACCACATCGACCTGGGCG
GAAACTTCGCCACCTTTGCCGGGTGGGTCCTCCCTCCCGACCGGAAAATTCTCCTCGTGGCTGAACAGGCCCATGAGGCA
TCGGAAGCGGCAGTTGCGCTTCACCGGGTGGGGCTCGATCAGGTTATCGGCTACCTGGAGGGGGGGATGTTCGAATGGGC
CAAGGCAGGCTTTGGCACGGATCACGTCCCTCAACTTTCGGCACCCGAGCTGAACCAGCGCATCTCCTGCGGCGACGGGC
TGGTGCTGGTGGATGTGCGCTCCGTCGGTGAATTCGGGGCTGCCCACGTGGAAGGGGCGATCCACATTCCGGCTCCCCAG
CTCCGTACCCGCCATACCGAGCTTGACCCCGACCGGGACATCGCGCTGGTGTGCAGCACGGGCCACCGGTCGAGCCTGGC
GGCCAGCATCCTCAAGCGCAACGGCTTCAGCCGGGTCTGGAACGTGGCCGGCGGCATGACCGGCTTCAATGCCGCAGGGT
TCGCACCGGAATGCCCCCTCTGCGTGGTGCCCCACGGTCCGCGCTTCATGGGACGGTGA

Upstream 100 bases:

>100_bases
CAATATATGTGGTATTTATAATTAATGCTTGCTATGTGGATATTAGATGGAATAATAACTCATAAATATTTGCATATATT
CTTCCAAGGAGGGTTATCAC

Downstream 100 bases:

>100_bases
CGGGGGTAAAAACCATGATCTCATTTCTGACCATGACCGAATGGTCCCCCTATGCTGTGGGGATCGGCATCGGCCTCCTC
TCCTGCTTCGCCTTCGTCCT

Product: metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MFIQQFFVSGLAHSSYLLGGTSTCAIVDPRRDIEIYLDAAASMGMKITHILQTHLHADFVSGHLDLAEATGAVIVAPRSA
DCQFSHLDVAEGDSFRIDDLEIRVLETPGHTPEHITYVVVDHGRGPEPAVIFCGDTLFVGDVGRPDLFPGMALELAAKLY
GSLHEKLMALPPFCEVYPAHGAGSLCGRAMGAKRTSTVGYEKLYNGALAIGDRQRFITSLTTDMPAAPDHFSRCSDINRR
GPALVRTLPVPAPLPPQRFREAMAESDTVVLDVRGYAAFGGQHVPGSYHIDLGGNFATFAGWVLPPDRKILLVAEQAHEA
SEAAVALHRVGLDQVIGYLEGGMFEWAKAGFGTDHVPQLSAPELNQRISCGDGLVLVDVRSVGEFGAAHVEGAIHIPAPQ
LRTRHTELDPDRDIALVCSTGHRSSLAASILKRNGFSRVWNVAGGMTGFNAAGFAPECPLCVVPHGPRFMGR

Sequences:

>Translated_472_residues
MFIQQFFVSGLAHSSYLLGGTSTCAIVDPRRDIEIYLDAAASMGMKITHILQTHLHADFVSGHLDLAEATGAVIVAPRSA
DCQFSHLDVAEGDSFRIDDLEIRVLETPGHTPEHITYVVVDHGRGPEPAVIFCGDTLFVGDVGRPDLFPGMALELAAKLY
GSLHEKLMALPPFCEVYPAHGAGSLCGRAMGAKRTSTVGYEKLYNGALAIGDRQRFITSLTTDMPAAPDHFSRCSDINRR
GPALVRTLPVPAPLPPQRFREAMAESDTVVLDVRGYAAFGGQHVPGSYHIDLGGNFATFAGWVLPPDRKILLVAEQAHEA
SEAAVALHRVGLDQVIGYLEGGMFEWAKAGFGTDHVPQLSAPELNQRISCGDGLVLVDVRSVGEFGAAHVEGAIHIPAPQ
LRTRHTELDPDRDIALVCSTGHRSSLAASILKRNGFSRVWNVAGGMTGFNAAGFAPECPLCVVPHGPRFMGR
>Mature_472_residues
MFIQQFFVSGLAHSSYLLGGTSTCAIVDPRRDIEIYLDAAASMGMKITHILQTHLHADFVSGHLDLAEATGAVIVAPRSA
DCQFSHLDVAEGDSFRIDDLEIRVLETPGHTPEHITYVVVDHGRGPEPAVIFCGDTLFVGDVGRPDLFPGMALELAAKLY
GSLHEKLMALPPFCEVYPAHGAGSLCGRAMGAKRTSTVGYEKLYNGALAIGDRQRFITSLTTDMPAAPDHFSRCSDINRR
GPALVRTLPVPAPLPPQRFREAMAESDTVVLDVRGYAAFGGQHVPGSYHIDLGGNFATFAGWVLPPDRKILLVAEQAHEA
SEAAVALHRVGLDQVIGYLEGGMFEWAKAGFGTDHVPQLSAPELNQRISCGDGLVLVDVRSVGEFGAAHVEGAIHIPAPQ
LRTRHTELDPDRDIALVCSTGHRSSLAASILKRNGFSRVWNVAGGMTGFNAAGFAPECPLCVVPHGPRFMGR

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=188, Percent_Identity=30.8510638297872, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI94538322, Length=162, Percent_Identity=34.5679012345679, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI94538320, Length=162, Percent_Identity=34.5679012345679, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787158, Length=205, Percent_Identity=28.780487804878, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221330176, Length=226, Percent_Identity=31.858407079646, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 50638; Mature: 50638

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50206 RHODANESE_3 ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIQQFFVSGLAHSSYLLGGTSTCAIVDPRRDIEIYLDAAASMGMKITHILQTHLHADFV
CCHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEEEEEEHHHCCCHHHHHHHHHHHHHHH
SGHLDLAEATGAVIVAPRSADCQFSHLDVAEGDSFRIDDLEIRVLETPGHTPEHITYVVV
CCCEEHHHCCCEEEEECCCCCCEEEEEECCCCCCEEECCEEEEEEECCCCCCCEEEEEEE
DHGRGPEPAVIFCGDTLFVGDVGRPDLFPGMALELAAKLYGSLHEKLMALPPFCEVYPAH
ECCCCCCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEEECCC
GAGSLCGRAMGAKRTSTVGYEKLYNGALAIGDRQRFITSLTTDMPAAPDHFSRCSDINRR
CCHHHHHHHHCCCCCCCCCHHHHHCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHCCCCC
GPALVRTLPVPAPLPPQRFREAMAESDTVVLDVRGYAAFGGQHVPGSYHIDLGGNFATFA
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCEEEEECCCCCHHHC
GWVLPPDRKILLVAEQAHEASEAAVALHRVGLDQVIGYLEGGMFEWAKAGFGTDHVPQLS
CEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCC
APELNQRISCGDGLVLVDVRSVGEFGAAHVEGAIHIPAPQLRTRHTELDPDRDIALVCST
CCCCCCCCCCCCCEEEEEECCCCCCCCHHCCCEEECCCCCHHCCCCCCCCCCCEEEEECC
GHRSSLAASILKRNGFSRVWNVAGGMTGFNAAGFAPECPLCVVPHGPRFMGR
CCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MFIQQFFVSGLAHSSYLLGGTSTCAIVDPRRDIEIYLDAAASMGMKITHILQTHLHADFV
CCHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEEEEEEHHHCCCHHHHHHHHHHHHHHH
SGHLDLAEATGAVIVAPRSADCQFSHLDVAEGDSFRIDDLEIRVLETPGHTPEHITYVVV
CCCEEHHHCCCEEEEECCCCCCEEEEEECCCCCCEEECCEEEEEEECCCCCCCEEEEEEE
DHGRGPEPAVIFCGDTLFVGDVGRPDLFPGMALELAAKLYGSLHEKLMALPPFCEVYPAH
ECCCCCCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEEECCC
GAGSLCGRAMGAKRTSTVGYEKLYNGALAIGDRQRFITSLTTDMPAAPDHFSRCSDINRR
CCHHHHHHHHCCCCCCCCCHHHHHCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHCCCCC
GPALVRTLPVPAPLPPQRFREAMAESDTVVLDVRGYAAFGGQHVPGSYHIDLGGNFATFA
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCEEEEECCCCCHHHC
GWVLPPDRKILLVAEQAHEASEAAVALHRVGLDQVIGYLEGGMFEWAKAGFGTDHVPQLS
CEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCC
APELNQRISCGDGLVLVDVRSVGEFGAAHVEGAIHIPAPQLRTRHTELDPDRDIALVCST
CCCCCCCCCCCCCEEEEEECCCCCCCCHHCCCEEECCCCCHHCCCCCCCCCCCEEEEECC
GHRSSLAASILKRNGFSRVWNVAGGMTGFNAAGFAPECPLCVVPHGPRFMGR
CCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]