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The map label for this gene is cobS [H]

Identifier: 39997256

GI number: 39997256

Start: 2372074

End: 2373015

Strand: Direct

Name: cobS [H]

Synonym: GSU2158

Alternate gene names: 39997256

Gene position: 2372074-2373015 (Clockwise)

Preceding gene: 39997255

Following gene: 39997257

Centisome position: 62.19

GC content: 58.7

Gene sequence:

>942_bases
ATGAACTACGAAATCAGAAGCACGTTCAATATCGACGCGCCCAAATCCGTCACCATCAAGGGAAGAACACCGGGACATCC
GGCGGTTCCCCAACAGGATCTCCAGTACATTTTCCGGCAGTCAACCCTGTCCGACCTGTTCACCTGGTATCTCCTCGGTG
AACGCTCACTCTATCTCACCGGCCCGACCGGCTGCGGGAAATCCTCTGTCATCATTGAGGTTGCCGCACGGCTCAACATC
CCCCTCTGGAATGTCGTCGCCCACTCCCGGCTGGAAACTCCGGAACTGATCGGCGGCTATCGGCTCAATGCCGGCGGAGG
AATGGATTTTGTGCATGGGCCGCTCATCATTGCCATGAAGGAAGGTGGCTGGTTTCTGATCGATGAAATCGATCTGCTCG
ATCCTTCCACTGCTGCGGGACTGAACGGTATTGCCGAAGGCCGCCCCATCACTATTCCGGAAACGGGAGAAGTGGTAACG
GCTCATCCGGACTTCCGTTTCATCGCCACCGCCAACTCAAATGGAGCCGGTGACGCTACAGGCCTCTACCAGGGGATACT
GCGGCAGAACCTGGCTTTCCTCGACCGCTTCTACATGATCGAGGTCGGTTATCCCGACCAGGACATTGAAAAGAAAATCC
TGACCGAAGTGGCGCCATCCGTCGGCAGCGACATCAGAGACCGCATGGTGGCAATCGCTAACGAGATCAGAGCCCTGTTT
GTCAAAGGGGAGACGGAAGTCACCCTCTCGACCCGCACCCTGACCCGGTGGGCACGCATCACCGCCTTCCAGGGACGGGC
CGCGGCCAGCCAGGGAATGTCCAACGGCGAAACACTTACCAAGGCCTTCGACCGGGCTCTCGGCTTCCGGGCTGAACCCG
ATACCCGAACCGCCCTGCACGCTGTATTGCAGCGTCACTTCGGGGACAGGAGGTCGCCATGA

Upstream 100 bases:

>100_bases
GACACACACTACCCATCGACACCTGGCAGGGAGAGCACGACATCCCTGCAGGGGAGTCTGTCTCCCTGTCCGGTTACCAC
ACACTGCACAGGAGGCAGAC

Downstream 100 bases:

>100_bases
GCAGATACCGGGCACTCAAATCATCCGTGGATCTGCACCTGCAGGATCTGATCAGGAATCACGACAAGGTCTATCACCTG
GCGGTATTCGAACGTAACGA

Product: cobS protein

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNYEIRSTFNIDAPKSVTIKGRTPGHPAVPQQDLQYIFRQSTLSDLFTWYLLGERSLYLTGPTGCGKSSVIIEVAARLNI
PLWNVVAHSRLETPELIGGYRLNAGGGMDFVHGPLIIAMKEGGWFLIDEIDLLDPSTAAGLNGIAEGRPITIPETGEVVT
AHPDFRFIATANSNGAGDATGLYQGILRQNLAFLDRFYMIEVGYPDQDIEKKILTEVAPSVGSDIRDRMVAIANEIRALF
VKGETEVTLSTRTLTRWARITAFQGRAAASQGMSNGETLTKAFDRALGFRAEPDTRTALHAVLQRHFGDRRSP

Sequences:

>Translated_313_residues
MNYEIRSTFNIDAPKSVTIKGRTPGHPAVPQQDLQYIFRQSTLSDLFTWYLLGERSLYLTGPTGCGKSSVIIEVAARLNI
PLWNVVAHSRLETPELIGGYRLNAGGGMDFVHGPLIIAMKEGGWFLIDEIDLLDPSTAAGLNGIAEGRPITIPETGEVVT
AHPDFRFIATANSNGAGDATGLYQGILRQNLAFLDRFYMIEVGYPDQDIEKKILTEVAPSVGSDIRDRMVAIANEIRALF
VKGETEVTLSTRTLTRWARITAFQGRAAASQGMSNGETLTKAFDRALGFRAEPDTRTALHAVLQRHFGDRRSP
>Mature_313_residues
MNYEIRSTFNIDAPKSVTIKGRTPGHPAVPQQDLQYIFRQSTLSDLFTWYLLGERSLYLTGPTGCGKSSVIIEVAARLNI
PLWNVVAHSRLETPELIGGYRLNAGGGMDFVHGPLIIAMKEGGWFLIDEIDLLDPSTAAGLNGIAEGRPITIPETGEVVT
AHPDFRFIATANSNGAGDATGLYQGILRQNLAFLDRFYMIEVGYPDQDIEKKILTEVAPSVGSDIRDRMVAIANEIRALF
VKGETEVTLSTRTLTRWARITAFQGRAAASQGMSNGETLTKAFDRALGFRAEPDTRTALHAVLQRHFGDRRSP

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=236, Percent_Identity=29.2372881355932, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25145616, Length=128, Percent_Identity=35.15625, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323135, Length=220, Percent_Identity=31.3636363636364, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI161076562, Length=234, Percent_Identity=29.9145299145299, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161076560, Length=234, Percent_Identity=29.9145299145299, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 34335; Mature: 34335

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYEIRSTFNIDAPKSVTIKGRTPGHPAVPQQDLQYIFRQSTLSDLFTWYLLGERSLYLT
CCEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEE
GPTGCGKSSVIIEVAARLNIPLWNVVAHSRLETPELIGGYRLNAGGGMDFVHGPLIIAMK
CCCCCCCCCEEEEEEHHCCCCHHHHHHHCCCCCCHHHCCEEECCCCCCCEECCCEEEEEE
EGGWFLIDEIDLLDPSTAAGLNGIAEGRPITIPETGEVVTAHPDFRFIATANSNGAGDAT
CCCEEEEEEEECCCCCHHCCCCCCCCCCCEECCCCCCEEEECCCEEEEEECCCCCCCCHH
GLYQGILRQNLAFLDRFYMIEVGYPDQDIEKKILTEVAPSVGSDIRDRMVAIANEIRALF
HHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEE
VKGETEVTLSTRTLTRWARITAFQGRAAASQGMSNGETLTKAFDRALGFRAEPDTRTALH
EECCCEEEEEHHHHHHHHHHHEECCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
AVLQRHFGDRRSP
HHHHHHCCCCCCC
>Mature Secondary Structure
MNYEIRSTFNIDAPKSVTIKGRTPGHPAVPQQDLQYIFRQSTLSDLFTWYLLGERSLYLT
CCEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEE
GPTGCGKSSVIIEVAARLNIPLWNVVAHSRLETPELIGGYRLNAGGGMDFVHGPLIIAMK
CCCCCCCCCEEEEEEHHCCCCHHHHHHHCCCCCCHHHCCEEECCCCCCCEECCCEEEEEE
EGGWFLIDEIDLLDPSTAAGLNGIAEGRPITIPETGEVVTAHPDFRFIATANSNGAGDAT
CCCEEEEEEEECCCCCHHCCCCCCCCCCCEECCCCCCEEEECCCEEEEEECCCCCCCCHH
GLYQGILRQNLAFLDRFYMIEVGYPDQDIEKKILTEVAPSVGSDIRDRMVAIANEIRALF
HHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEE
VKGETEVTLSTRTLTRWARITAFQGRAAASQGMSNGETLTKAFDRALGFRAEPDTRTALH
EECCCEEEEEHHHHHHHHHHHEECCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
AVLQRHFGDRRSP
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]